李云庆
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资料介绍
个人简历
李云庆,空军军医大学(原第四军医大学)梁銶琚脑研究中心教授、主任、博士生导师。1984年毕业于第四军医大学临床医学系,并分别在第四军医大学(1989年)和日本京都大学医学部(1993年)获得博士学位。至今,以第一获奖者身份获国家科技进步一等奖(2009年)、中华医学科技进步一等奖(2004年)和陕西省科学技术一等奖(2003年)各1项;承担国家级研究课题15项;发表SCI论文168篇,他引3800多次;主编教材专著18部。1996年获“国家杰出青年科学基金”资助,1999年获中国科协“求是奖”,被评为“全国优秀科技工作者”和“陕西省高校教学名师”,并荣立一等功;2014年被评为“军队科技领军人才”并获“军队优秀专业技术人才奖”;2017获“何梁何利科技进步奖”。已经培养博士后6名、博士研究生和硕士研究生82名,其中1名博士生获得“全国优秀博士论文”、1名博士生获“军队优秀博士论文”、1名硕士生获“军队优秀硕士论文”、4名博士生获“陕西省优秀博士论文”。研究领域
1.痛与镇痛和痒与止痒的中枢神经机制2.外周躯体痛信息传递和调控的神经机制3.头面部躯体运动和肠道内脏运动调控的神经机制4.内脏痛信息传递和调控的神经机制"主要从事神经信号(尤其是痛、痒、听觉等感觉信息)传递和调控机制的研究工作。近年来,应用神经形态学、电生理学、分子生物学、行为药理学、光遗传学等技术,在中枢镇痛和慢性痛及慢性痒的神经机理,内吗啡肽和吗啡镇痛及其副作用的机制,大脑皮层直接调节脊髓运动和痛觉神经元的活动通路和机制,牵涉痛发生和调控机制等研究领域都取得了一些进展。"近期论文
1. Zhao ZQ, Liu XY, Jeffry J, Karunarathne WKA, Li JL, Munanairi A, Zhang XY, Li H, Sun YG, Wan L, Wu ZY, Kim S, Huo FQ, Mo P, Barry DM, Zhang CK, Kim JY, Gautam N, Renner KJ,Li YQ, Chen ZF. Descending Control of Itch Transmission by the Serotonergic System via 5-HT1A-Facilitated GRP-GRPR Signaling. Neuron , 2015, Article Number: 12347, http://dx.doi.org/10.1016/j.neuron. 2014.10.0032. Chen T, Lu JS, Song Q, Liu MG, Koga K, Descalzi D,Li YQ*, Zhuo M*. Pharmacological rescue of cortical synaptic and network potentiation in a mouse model for fragile X syndrome. Neuropsychopharmacology , 2014, 39(8): 1955-1967.3. Qi J, Lu YC, ZhangT, Wang W, Dong YL,Li YQ*. Activation of extracellular signal-regulated kinase1/2 in the medial prefrontal cortex contributes to stress-induced hyperalgesia. Molecular Neurobiology , 2014,50(3): 1013-1023.4. Wu SX, Wang W, Li H, Wang YY, Feng YP,Li YQ*.The synaptic connectivity that underlies the noxious transmission and modulation within the superficial dorsal horn of the spinal cord. Prog Neurobiol. 2010, 91(1): 38-54.5. Mei XP, Zhang H, Wang W, Wei YY, Zhai MZ, Wang W, Xu LX,Li YQ*.Inhibition of spinal astrocytic c-Jun N-terminal kinase (JNK) activation correlates with the analgesic effects of ketamine in neuropathic pain.J Neuroinflammation . 2011, 8(1):6-18.6. Chen T, Taniguchi W, Chen QY, Tozaki-Saitoh H, Song Q, Liu RH, Koga K, Matsuda T, Sugimura Y, Wang J, Li ZH, Lu YC, Inoue K, Tsuda M,Li YQ*,Nakatsuka T*,Zhuo M*. Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex. Nature Communications , 2018 May 14; 9(1):1886.7. Zhang FX, Ge SN, Dong YL, Shi J, Feng YP, Li Y,Li YQ*,Li JL*. Vesicular glutamate transporter isoforms: the essential players in the somatosensory systems.Progress in Neurobiology , 2018; 171(2018): 72-89.8.Wan FP, Bai Y, Kou ZZ, Zhang T, Li H, Wang YY,Li YQ*. Endomorphin-2inhibition of substance P signaling within lamina I of the spinal cord is impaired in diabetic neuropathic pain rats. Frontiers in Molecular Neuroscience , 2017 Jan 10;9:1679.Qi J, Li H, Zhao TB, Lu YC, Zhang T, Li JL, Dong YL,Li YQ*. Inhibitory effect of endomorphin-2 binding to the µ-opioid receptor in the rat pre-Bötzinger complex on the breathing activity. Molecular Neurobiology , 2017 Jan;54(1):461-46910.Kou ZZ, Wan FP, Bai Y, Li CY, Hu JC, Zhang GT, Zhang T, Chen T, Wang YY, Li H,Li YQ*. Decreased endomorphin-2 andμ-opioid receptor in the spinal cord are associated with painful diabetic neuropathy. Frontiers in Molecular Neuroscience, 2016; 9: 8011.Chen T, Li J, Feng B, Hui R, Dong YL, Huo FQ, Zhang T, Yin JB, Du YQ,Li YQ*. Mechanism underlying the analgesic effect exerted by endomorphin-1 in the rat ventrolateral periaqueductal gray. Molecular Neurobiology , 2016; 53(3): 2036–205312. Zhao ZQ, Wan L, Liu XY, Huo FQ, Li H, Barry DM, Krieger S, Kim S, Liu ZC, Xu J, Rogers BE,Li YQ, Chen ZF.Cross-inhibition of NMBR and GRPR signaling maintains normal histaminergic itch transmission. Journal of Neuroscience , 2014; 34(37):12402~1241413. Qi J, Chen C, Lu YC, Zhang T, Xu H, Cui YY, Chen YZ, Wang W, Dong YL,Li YQ*.Activation of extracellular signal-regulated kinase1/2 in the medial prefrontal cortex contributes to stress-induced hyperalgesia. Molecular Neurobiology , 2014; 50(3):1013~102314.Chen L, Zhu L, Wang K, Wang W, Mei XP, Liu T, Zhang FX, Wang W, Chen T,Li YQ*.Antinociceptive effect of prostatic acid phosphatase in a rat model of cancer-induced bone pain. Pain Physician , 2013; 16(6):533~54615.Kou ZZ,Li CY, Tang J, Hu JC,Qu J, Liao YH, Wu SX, Li H,Li YQ*. Down-regulation of insulin signaling is involved in painful diabetic neuropathy in type 2 diabetes. Pain Physician , 2013; 16(2):E71~E83曾被聘为日本京都大学医学部高级脑形态学研究室客座教授(1996-1999年)、日本国立生理学研究所高级脑形态学研究室客座教授(2002-2004年)和长期担任中国解剖学会理事长以及中国神经科学学会常务理事。现任中国解剖学会副理事长,国际解剖学工作者联盟(IFAA)副主席,国际形态学大会(ISMS)侯任主席,亚太地区解剖学会(APICA)执委,《神经解剖学杂志》主编,SCI期刊 Frontiers in Neuroanatomy 副主编以及 Molecular Pain 、Journal of Chemical Neuroanatomy 和 Histochemistry and Cell Biology 的编委。标签: 四川大学 华西基础医学与法医学院
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