个人简历
1996~2001年，四川大学华西药学院，临床药学专业本科 2001~2004年，四川大学华西药学院，药剂学专业硕士研究生 2004~2007年，四川大学华西药学院，药剂学专业博士研究生 2007~2011年，四川大学华西药学院，讲师 2015~2016年，夏威夷大学癌症研究中心代谢组学实验室，访问学者 2011~，四川大学华西药学院，副教授
研究领域
1.人类胆汁酸代谢与药物代谢的相互作用研究：1). 探索人类次级胆酸的三级代谢途径和机制，构建人类胆汁酸的宿主-肠道微生物协同代谢网络；2). 人类胆汁酸三级代谢与药物代谢的相互作用的基础与临床转化研究。 2.天然药物药代动力学研究：1). 探索具有重要生理活性的复杂结构天然药物的生物转化过程；1). 探索化学组成复杂的天然药物药代动力学研究的代谢组学技术方法。
近期论文
1.Guoxiang Xie, Shouli Wang, Hua Zhang, Aihua Zhao, Jiajian Liu, Yueming Ma, Ke Lan, Yan Ni, Changxiao Liu, Ping Liu*, Tianlu Chen*, Wei Jia*. Poly-Pharmacokinetic Study of a Multicomponent Herbal Medicine in Healthy Chinese Volunteers. CLIN PHARMACOL THER, 2017, DOI: 10.1002/cpt.784. 2.Shanshan Yin, Mingming Su, Guoxiang Xie, Xuejing Li, Runmin Wei, Changxiao Liu, Ke Lan*, Wei Jia*. Factors affecting separation and detection of bile acids by liquid chromatography coupled with mass spectrometry at negative mode. ANAL BIOANAL CHEM. 2017, 409(23):5533-5545. 3.Xue Fan, Shan-Shan Yin, Xue-Jing Li, Kui Yang, Liang Xu, Ke Lan*. Hydroxylation metabolisms of crassicauline A in rats under toxic dose. EUR J DRUG METAB PH, 2017, 42(5): 857-869. 4.Ke Lan, Mingming Su, Guoxiang Xie, Brian C. Ferslew, Kim Brouwer, Cynthia Rajani, Changxiao Liu, Wei Jia*. Key role of 12-hydroxy group for the negative ion fragmentation of unconjugated C24 bile acids. ANAL CHEM, 2016, 88 (14): 7041-7048. 5.Jing Yang, An-Qi Wang, Xue-jing Li, Xue Fan, Shan-Shan Yin, Ke Lan*. A chemical profiling strategy for semi-quantitative analysis of flavonoids in Ginkgo extracts. J PHARMACEUT BIOMED, 2016, 123: 147-154. 6.Ke Lan*, Xue-Jing Li, Kui Yang, Gang Du, Liang Xu. Characterizations of the hydrolyzed products of ginkgolide A and ginkgolide B based on liquid chromatography coupled with mass spectrometry analysis. J PHARMACEUT BIOMED, 2016, 118:113-122. 7.Xue-Jing Li, Kui Yang, Gang Du, Liang Xu, Ke Lan*. Understanding the regioselective hydrolysis of ginkgolide B under physiological environments based on generations, detections, identifications and semi-quantitative determinations of the hydrolyzed products. ANAL BIOANAL CHEM. 2015, 407(26): 7945-7956. 8.Xue-Jing Li, Yu-Qing Wang, Jing Yang, Xue Fan, Ling Wang, Kui Yang, Ke Lan*. Semi-quantitative determination of monocarboxylate forms of ginkgolide B in plasma by UPLC-MS. ANAL BIOANAL CHEM. 2015, 407(14): 4121-4129. 9.Ke Lan, Guoxiang Xie, Wei Jia*. Towards polypharmacokinetics: pharmacokinetics of multi-component drugs and herbal medicines using a metabolomics approach. EVID BASED COMPLEMENT ALTERNAT MED. 2013, 819147.
