个人简历

1978年3月～1981年12月，四川医学院药学系，药学专业学习，获医学学士学位； 1991年～1994年，华西医科大学药学院，药剂学专业博士研究生学习，获理学博士学位； 1982年1月～ 四川医学院药学系、华西医科大学药学院、四川大学华西药学院任助教、讲师、副教授、教授、博士研究生导师。 现为四川大学华西药学院临床药学与药事管理学系主任，临床药学研究中心主任。

研究领域

研究领域：生物药剂学、药动学、临床药学与药学教育 研究方向：药动学与药物制剂生物等效性评价；临床药学与药学教育；药物新制剂的设计与评价；

近期论文

1.Rational application of fructose-1,6-diphosphate: From the perspective of pharmacokinetics.[J]. Acta Pharmaceutica, 2015, 65(2):147; 2.Fluorofenidone-loaded PLGA microspheres for targeted treatment of paraquat-induced acute lung injury in rats[J]. Rsc Advances, 2015, 5(38):30153; 3.Pressure garment therapy for preventing hypertrophic and keloid scarring after a major burn injury[M]// The Cochrane Library. John Wiley & Sons, Ltd, 2015. 4.Poly(ethylene glycol)-block-poly(ε-caprolactone)– and phospholipid-based stealth nanoparticles with enhanced therapeutic efficacy on murine breast cancer by improved intracellular drug delivery，International Journal of Nanomedicine，2015，10：1791; 5.Prevalence of Desloratadine Slow-metabolizer Phenotype and Food-dependent Pharmacokinetics of Desloratadine in Healthy Chinese Volunteers，Clinical Drug Investigation,2015，10：1791; 6.Reversal of multidrug resistance in cancer treatment by regulating multidrug resistance gene1: focus on nuclear receptors and epigenetics，Journal of Chinese Pharmaceutical Sciences，2015,24（5）：273; 7.Simultaneous determination of leucine, isoleucine and valine in Beagle dog plasma by HPLC–MS/MS and its application to a pharmacokinetic study, Journal of Pharmaceutical and Biomedical Analysis, 2015，114：426; 8.Pharmacokinetic Properties of Allantoin and the Effect of Food in Chinese Volunteers, Latin American Journal of Pharmacy,2015, 34 (7): 1343; 9.Efficacy and Safety of Ledipasvir/Sofosbuvir with and without Ribavirin in Patients with Chronic Hepatitis C Virus Genotype 1 Infection: a meta-analysis[J]. International Journal of Infectious Diseases Ijid Official Publication of the International Society for Infectious Diseases, 2016, 55(C):56; 10.Efficacy and safety of vildagliptin combined with metformin in the treatment of type 2 diabetes mellitus: a systematic review and meta-analysis. International Journal of Clinical and Experimental Medicine，2016;9(6):9495-9503. 11.Prognostic value of NRF2 in breast cancer patients and its role as a tumor suppressor by directly inhibiting HER2 expression ，Int J Clin Exp Pathol 2016;9(4):4292; 12.Synthesis and Evaluation of Two Novel Naphthol Derivativesas Novel Cholinesterase Inhibitors[J]. 结构化学, 2016, 35(3):371-374. 13.Simultaneous bioanalysis of rasagiline and its major metabolites in human plasma by LC–MS/MS: Application to a clinical pharmacokinetic study, Journal of Pharmaceutical and Biomedical Analysis, 2016, 125:280； 14.Enhanced anticancer efficacy of paclitaxel through multistage tumor-targeting liposomes modified with RGD and KlA peptides，International Journal of Nanomedicine，2017:12 1517; 15.Chemopreventive effects of atractylenolide II on mammary tumorigenesis via activating Nrf2-ARE pathway，ONCOTARGET，2017，8（44）：77500;