个人简历

1997-2001年 四川大学华西药学院药物化学专业本科 2001-2006年 四川大学华西药学院硕博连读 2008-2010年 美国宾西法尼亚州匹兹堡大学药学院事博士后

研究领域

""本小组致力于主动靶向药物设计、合成与靶向性研究，利用配体与靶器官、细胞的特异性结合，赋予药物分子或载体靶向性。最近，我们针对血脑屏障上的营养物质转运体及锁定系统开展了一系列探索性的研究，设计了多种前药及配体，初步展示了这些化合物作为靶向分子潜在的应用价值。"""本小组致力于主动靶向药物设计、合成与靶向性研究，利用配体与靶器官、细胞的特异性结合，赋予药物分子或载体靶向性。最近，我们针对血脑屏障上的营养物质转运体及锁定系统开展了一系列探索性的研究，设计了多种前药及配体，初步展示了这些化合物作为靶向分子潜在的应用价值。"

近期论文

1. Xiaojun Ma, Guanghui Lv, Xu Cheng, Weijian Li, Rui Sang, Yong Zhang, Qiantao Wang, Li Hai,* and Yong Wu*. Novel cyclodextrin-modified h-BN@Pd(II) nanomaterial: An efficient and recoverable catalyst for ligand-free C-C crosscoupling reactions in water. Applied Organometallic Chemistry, 2017, 0:e3854. 2. Ren-Jun Li, Yan Zhou, Yang Zheng, Li Hai *, Yong Wu*. The synthesis and biological evaluation of unsymmetrical 2,2-di(1H-indol-3-yl)-N-phenylacetamide derivatives. Tetrahedron Letters, 2016, 57(26): 2829-2832. 3. Yang Zheng, Ren-Jun Li, Zhen Zhan, Yan Zhou, Li Hai*, Yong Wu*. Fe-catalyzed regioselective Friedel–Crafts hydroxyalkylation of N-substituted glyoxylamide with indoles. Chinese Chemical Letters, 2016, 27(1): 41-46. 4. Yaoling Wang, Xu Cheng, Zhen Zhan, Xiaojun Ma, Ruifang Nie, Li Hai*, Yong Wu*. IBX-promoted domino reaction of a-hydroxy amides: A facile one-pot synthesis of isatins. RSC Advances, 2016, 6, 2870 – 2874. 5. Zhan Zhen, Zhang Guoyao, Cheng Xu, Lü Guanghui, Zheng Yang, Hai Li*, Wu Yong*. CuCl2-Promoted Friedel-Crafts Hydroxyalkylations of Indoles. Chinese Journal of Organic Chemistry, 2015, 35(12): 2559-2567. 6. Zhen Zhan, Xu Cheng, Yang Zheng, Xiaojun Ma, Xiaoyu Wang, Li Hai*, Yong Wu*. PhI(OAc)2-promoted metal-free oxidation of 2-oxoaldehydes: A facile one-pot synthesis of cyanoformamides. RSC Advances, 2015, 5, 82800 – 82803. 7. Jue Li, Yang Zheng, Xinling Yu, Songyang Lv, Qiantao Wang, Li Hai*, Yong Wu*.Synthesis of isatins by the palladium-catalyzed intramolecular acylation of unactivated aryl C(sp2)-H bond. RSC Advances, 2015, 5, 103280 – 103283. 8. Zhen Zhan, Xu Cheng, Xiaojun Ma, Jie Li, Li Hai* and Yong Wu*. Hydrogen peroxide-promoted metal free oxidative amidation of 2-oxoaldehydes: A facile access to unsymmetrical oxamides. Tetrahedron, 2015, 71(38): 6928-6934. 9. Yi Zhao, Xiaolong Li, Hong Liu, Yongguo Yu, Li Hai, Li Guo*, Yong Wu*. First synthesis and characterization for the stereoisomers of Ulipristal acetate. Steroids, 2015, 95: 7-16. 10. Yi He, Xiaolong Li, Jue Li, Xiaocen Li, Li Guo, Li Hai*, Yong Wu*. A novel and convenient route for the construction of 5-((1H-1,2,4-triazol-1-yl)methyl)-1H-indoles and its application in the synthesis of Rizatriptan. †Yi He and Xiaolong Li are co-first authors. Tetrahedron Letters, 2014, 55(29): 3938-3941. 11. Yi Zhao, Boyi Qu, Xueying Wu, Xiaocen Li, Qingqing Liu, Xiuxiu Jin, Li Guo, Li Hai*, Yong Wu*. Design, synthesis and biological evaluation of brain targeting l-ascorbic acid prodrugs of ibuprofen with “lock-in” function. European Journal of Medicinal Chemistry, 2014, 82: 314-323. 12. Xu Cheng, Xiaocen Li, Yanjun Duan, Yongguo Yu, Li Hai*, Yong Wu*. A new and efficient method for the synthesis of Ulipristal acetate. Steroids, 2014, 84:78-83. 13. Xiaocen Li, Boyi Qu, Xiuxiu Jin, Li Hai*, Yong Wu*. Design, synthesis and biological evaluation for docetaxel loaded brain targeting liposome with “lock-in” function. Journal of drug targeting, 2014, 22(3): 251-261. 14. Yun Ren, RenJun Li, Yong Deng, Mei Guan, Yong Wu*, Li Hai*. First synthesis and characterization of SRR/RSS-Ezetimibe. Tetrahedron Letters, 2013, 54(48): 6443–6446. Nov 27. 15. Yun He, Erxiao Sun, Yi Zhao, Li Hai*, Yong Wu*. The one-pot synthesis of 4-Aryl-1H-1,2,3-triazoles without azides and metal catalization. Tetrahedron Letters, 2014, 55(1): 111-115. 16. Xue-Ying Wu, Xiao-Cen Li, Jie Mi, Jing You, Li Hai*. Design, synthesis and preliminary biological evaluation of brain targeting L-ascorbic acid prodrugs of ibuprofen. Chinese Chemical Letters. 2013, 24(2): 117–119. 17. Jianbo Wu, Xueying Wu, Fan Lei, Huajie Yuan, Li Hai, Yong Wu*. Design, synthesis and antibacterial activities of a series of new 2-oxaisocephems. Bioorg. Med. Chem. Lett., 2012, 22(16), 5293–5296. 18. Fulan Xie, Nian Yao, Yao Qin, Qianyu Zhang, Huali Chen, Mingqing Yuan, Jie Tang, Xiankun Li, Wei Fan, Qiang Zhang, Yong Wu, Li Hai*, Qin He*. Investigation of glucose-modified liposomes using polyethylene glycols with different chain lengths as the linkers for brain targeting. Int J Nanomedicine, 2012; 7: 163–175. 19. Wei Fan, Yong Wu, Xian-Kun Li, Nian Yao, Xun Li, Yong-Guo Yu, Li Hai*. Design, synthesis and biological evaluation of brain-specific glucosyl thiamine disulfide prodrugs of naproxen, European Journal of Medicinal Chemistry, 2011, 46(9): 3651-3661. 20. Barbara Bonamassa, Li Hai, Dexi Liu*. Hydrodynamic Gene Delivery and Its Applications in Pharmaceutical Research. Pharm Res, 2011, 28:694–701.