个人简历

韩俊宏，四川大学教授、博士生导师，表观遗传学研究室主任。已发表SCI论文20余篇，文章总被引用次数达1600多次；其中以第一作者身份在 Scienc、Cell 和 GeneDev 等期刊发表论文多篇。曾首先报道了一种新型组蛋白乙酰化酶及其维护基因组稳定性的机制，这一突破性成果发表于 Scienc；其它后续相关研究成果陆续发表于 J Biol Chem、Nature、Mol Cell、Nat Struct、Mol Biol、Plos Genet、AM J Resp Cell Mol、GeneDev 和 Cell 国际权威学术期刊。作为课题负责人承担过美国心脏学会（两项）、雄鹰癌症研究基金会和爱德华·肯德尔基金会的研究基金课题，国家自然科学基金面上项目（一项）共五项，并作为主要研究人员参与三项美国NIH R01基金、两项美国明尼苏达州政府基金；曾获得爱德华·肯德尔杰出研究奖。

研究领域

从事表观遗传学研究，主要研究方向集中在组蛋白修饰、DNA复制调控，肿瘤表观遗传学以及干细胞干性维持的表观遗传学调控等。""

近期论文

1. Haiyun Gan*, Chuanhe Yu*, Sujan Devbhandari, Sushma Sharma,Junhong Han, Andrei Chabes, Dirk Remus,Zhiguo Zhang. Checkpoint Kinase Rad53 Couples Leading and Lagging Strand DNA Synthesis under Replication Stress.Molecular Cell.2017, 68:446-455.
2. Shuqi Li, Zhiyun Xu, Jiawei Xu, Xuezheng Wang, Chuanhe Yu, Pu Zheng, Linyu Zuo, Haiyun Gan, Longtu Li, Sushma Sharma, Andrei Chabes, Di Li, Jiayi Yang, Yingying Chen, Sheng Wang, Yujie Sun, Sihao Zheng, Jinbao Li, Xuefeng Chen,Junhong Han, Kuiming Chan, Zhi Qi, Jianxun Feng* and Qing Li*. Rtt105 Promotes DNA Replication by Functioning as An RPA Chaperone.Molecular Cell. 2018.
3. Chuanhe Yu*, Haiyun Gan*,Junhong Han, Zhixiong Zhou,Shaodong Jia, Andrei Chabes,Gianrico Farrugia, Tamas Ordog, Zhiguo Zhang. Strand-Specific Analysis Shows Protein Binding at Replication Forks and PCNA Unloading from Lagging Strands when Forks Stall.Molecular Cell.2014 Nov.20, 54:551-563 (*Equal Contribution)
4.Rebecca J. Burgess, Junhong Han, Zhiguo Zhang. The Ddc1/Mec3/Rad17 Sliding Clamp Regulates Histone-histone Chaperone Interactions and DNA Replication-coupled Nucleosome Assembly in Budding Yeast.Journal of Biological Chemistry.2014 Feb.25, 289:10518-10529.
5.Junhong Han, Hui Zhang, Honglian Zhang, Zhiquan Wang, Hui Zhou and Zhiguo Zhang. A Cul4 E3 Ubiquitin Ligase Regulates Histone Hand-off During Nucleosome Assembly.Cell.2013. 155:817-829. (Highlighted by Faculty of 1000)