个人简历

2004.09-2008.07 复旦大学药学院，获理学学士学位\r
2008.09-2013.06 复旦大学药学院，获药剂学博士学位\r
2013.07-2014.06 四川大学华西药学院药剂系讲师\r
2014.07至今 四川大学华西药学院药剂系副教授、硕导\r
2015.10-2016.10 斯坦福大学医学院访问学者\r
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获得荣誉及学术任职：\r
1、2016年11月起担任《Journal of Microencapsulation》编委\r
2、2016年09月主编专著《Neurotoxicity of Nanomaterials and Nanomedicine》，Elsevier出版社\r
3、2016年08月担任《Current Drug Metabolism》客座主编，主编2016年第8期\r
4、2015年11月至今担任《药学学报》青年编委\r
5、2015年08月至今担任《中国医院药学杂志》通讯编委\r
6、2015年10月获中国药学会中恒青年药剂学奖\r
7、2015年04月博士论文获上海市优秀博士论文\r
8、2014年12月获四川大学青年骨干教师称号

研究领域

"""""新型脑靶向递药系统的设计和评价\r
具有环境敏感性的纳米递药系统及其材料的设计、合成和评价"

近期论文

Ruan Shaobo, Hu Chuan, Tang Xian, Cun Xingli, Xiao Wei, Shi Kairong, He Qin, Gao Huile*. Increased gold nanoparticle retention in brain tumors by in situ enzyme-induced aggregation. ACS Nano, 2016. (IF=13.334)\r
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Cun Xingli, Ruan Shaobo, Chen Jiantao, Zhang Li, Li Jianping, He Qin*, Gao Huile*. A dual strategy to improve the penetration and treatment of breast cancer by combining shrinking nanoparticles with collagen depletion by losartan. Acta Biomater, 2016, 31C: 186-196. (IF=6.008)\r
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Hu Guanlian#, Cun Xingli#, Ruan Shaobo, Shi Kairong, Wang Yang, Kuang Qifang, Hu Chuan, Xiao Wei, He Qin, Gao Huile*. Utilizing G2/M retention effect to enhance tumor accumulation of active targeting nanoparticles. Sci Rep, 2016, 6:27669. (IF=5.228)\r
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Hu Chuan#, Liu Yongmei#, Chen Jiantao, He Qin, Gao Huile*. A simple one-step synthesis of melanin-originated red shift emissive carbonaceous dots for bioimaging. J Colloid Interf Sci, 2016, 480: 85-90. (IF=3.782)\r
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Zheng Min, Ruan Shaobo, Liu Shi, Sun Tingting, Qu Dan, Zhao Haifeng, Xie Zhigang*, Gao Huile*, Jing Xiabin, Sun Zaicheng*. Self-targeting fluorescent carbon dots for diagnosis of brain cancer cells. ACS Nano, 2015, 9 (11): 11455–11461. (IF=13.334)\r
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Ruan Shaobo, Cao Xi, Cun Xingli, Hu Guanlian, Zhou Yi, Zhang Yanling, Lu Libao, He Qin, Gao Huile*. Matrix metalloproteinase-sensitive size-shrinkable nanoparticles for deep tumor penetration and pH triggered doxorubicin release. Biomaterials, 2015, 60: 100-110. (IF=8.387)\r
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Ruan Shaobo, Yuan Mingqing, Zhang Li, Hu Guanlian, Chen Jiantao, Cun Xingli, Zhang Qianyu, Yang Yuting, He Qin*, Gao Huile*. Tumor microenvironment sensitive doxorubicin delivery and release to glioma using angiopep-2 decorated gold nanoparticles. Biomaterials, 2015, 37:425-435. (IF=8.387)\r
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Ruan Shaobo, He Qin, Gao Huile*. Matrix metalloproteinase triggered size-shrinkable gelatin-gold fabricated nanoparticles for tumor microenvironment sensitive penetration and diagnosis of glioma. Nanoscale, 2015, 7(21): 9487-9496. (IF=7.76)\r
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Cun Xingli, Chen Jiantao, Ruan Shaobo, Zhang Li, Wan Jingyu, He Qin, Gao Huile*. A novel strategy through combining iRGD peptide with tumor microenvironment responsive and multistage nanoparticles for deep tumor penetration. ACS Appl Mater Inter, 2015, 7, 27458?27466. (IF=7.145)\r
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Hu Guanlian, Chun Xinli, Wang Yang, He Qin, Gao Huile*. Peptide mediated active targeting and intelligent particle size reduction-mediated enhanced penetrating of fabricated nanoparticles for triple-negative breast cancer treatment. Oncotarget, 2015, 6(38): 41258-41274. (IF=5.008)\r
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Ruan Shaobo, Chen Jiantao, Cun Xingli, Long Yang, Tang Jie, Qian Jun, Shen Shun, Jiang Xinguo, Zhu Jianhua, He Qin*, Gao Huile*. Noninvasive in vivo diagnosis of brain gliomas using RGD-decorated fluorescent carbonaceous nanospheres. J Biomed Nanotech, 2015, 11(12): 2148-2157. (IF=3.929)\r
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Gao Huile#, Cao Shijie#, Yang Zhi, Zhang Shuang, Pang Zhiqing, Jiang Xinguo. Preparation, characterization and anti-glioma effects of docetaxel-loaded, lipoprotein-like nanoparticles. J Biomed Nanotech, 2015, 11(12):2137-2147. (IF=3.929)\r
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Hu Guanlian, Wang Yang, He Qin*, Gao Huile*. Multistage drug delivery system based on microenvironment-responsive dendrimer-gelatin nanoparticles for deep tumor penetration. RSC Adv, 2015, 5: 85933-85937. (IF=3.289)\r
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Ruan Shaobo, Zhang Li, Chen Jiantao, Cao Tingwei, Yang Yuting, Liu Yayuan, He Qin, Gao Fabao*, Gao Huile*. Targeting delivery and deep penetration using multistage nanoparticles for triple-negative breast cancer. RSC Adv, 2015, 5:64303 - 64317. (IF=3.289)\r
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Chen Jiantao, Cun Xingli, Ruan Shaobo, Wang Yang, Zhang Yanling, He Qin*, Gao Huile*. Glioma cell targeting doxorubicin delivery and redox-responsive release using angiopep-2 decorated carbonaceous nanodots. RSC Adv, 2015, 5: 57045 - 57049. (IF=3.289) \r
Chen Jiantao, Sun Huaqin, Ruan Shaobo, Wang Yang, Shen Shun, Xu Wenming, He Qin, Gao Huile*. In vitro and in vivo toxicology of bare and PEGylated fluorescent carbonaceous nanodots in mice and zebrafish: the potential relation with autophagy. RSC Adv, 2015, 5: 38547-38557. (IF=3.289)\r
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Ruan Shaobo#, Qian Jun#, Shen Shun, Chen Jiantao, Cun Xingli, Zhu Jianhua, Jiang Xinguo, He Qin*, Gao Huile*. Non-invasive imaging of breast cancer using RGDyK functionalized fluorescent carbonaceous nanospheres. RSC Adv, 2015, 5: 25428-25436. (IF=3.289)\r
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Hu Guanlian#, Zhang Huiqing#, Zhang Li, Ruan Shaobo, He Qin, Gao Huile*. Integrin-mediated active tumor targeting and tumor microenvironment response dendrimer-gelatin nanoparticles for drug delivery and tumor treatment. Int J Pharm, 2015, 496: 1057-1068. (IF=3.994)\r
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Gao Huile*, Zhang Qianyu, Yang Yuting, Jiang Xinguo, He Qin*. Tumor homing cell penetrating peptide decorated nanoparticles used for enhanced tumor targeting delivery and therapy. Int J Pharm, 2015, 478: 240-250. (IF=3.994)\r
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Chen Jiantao#, Sun Huaqin#, Wang Weiliang, Xu Wenming, He Qin, Shen Shun, Qian Jun*, Gao Huile*. Polyethylene glycol modification reduces the cardiac toxicity of carbonaceous dots in mice and zebrafish model. Acta Pharmacol Sin, 2015, 36(11): 1349-1355. (IF=3.166)\r
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Gao Huile, Yang Zhi, Cao Shijie, Xiong Yang, Zhang Shuang, Pang Zhiqing, Jiang Xinguo*. Tumor cells and neovasculature dual targeting delivery for glioblastoma treatment. Biomaterials, 2014, 35(7): 2374-2382. (IF=8.557)\r
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Ruan Shaobo#, Qian Jun#, Shen Shun, Zhu Jianhua, Jiang Xinguo, He Qin, Gao Huile*. A simple one-step method to prepare fluorescent carbon dots and their potential application in non-invasive glioma imaging. Nanoscale, 2014, 6(17): 10040-10047. (IF=7.394)\r
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Gao Huile, Yang Zhi, Zhang Shuang, Pang Zhiqing, Liu Qingfeng, Jiang Xinguo*. Study of the pharmacology mechanisms of dual targeting drug delivery system with tumor microenvironment assays. Acta Biomateria, 2014, 10(2): 858-867. (IF=6.025)高被引论文\r
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Gao Huile, Hu Guanlian, Zhang Qianyu, Zhang Shuang, Jiang Xinguo, He Qin*. Pretreatment with chemotherapeutics for enhanced nanoparticles accumulation in tumor: the potential role of G2 cycle retention effect. Sci Rep, 2014,4: 4492. (IF=5.578)\r
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Ruan Shaobo#, Qian Jun#, Shen Shun, Chen Jiantao, Zhu Jianhua, Jiang Xinguo, He Qin*, Yang Wuli*, Gao Huile*. Near-infrared fluorescent carbonaceous nanodots for glioma imaging after angiopep-2 decoration. Bioconjug Chem, 2014, 25: 2252-2259. (IF=4.513)\r
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Ruan Shaobo, Wan Jingyu, Fu Yao, Han Ke, Li Xiang, Chen Jiantao, Zhang Qianyu, Shen Shun, He Qin, Gao Huile*. PEGylated fluorescent carbon nanoparticles for noninvasive heart imaging. Bioconjug Chem, 2014,25(6): 1061-1068. (IF=4.513)\r
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Gao Huile, Zhang Shuang, Cao Shijie, Yang Zhi, Pang Zhiqing, Jiang Xinguo*. Angiopep-2 and activatable cell penetrating peptide dual-functionalized nanoparticles for systemic glioma targeted delivery. Mol Pharm, 2014, 11(8): 2755-2763. (IF=4.384)\r
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Gao Huile, Xiong Yang, Zhang Shuang, Yang Zhi, Cao Shijie, Jiang Xinguo*. RGD and interleukin-13 peptide functionalized nanoparticles for enhanced glioblastoma cells and neovasculature dual targeting delivery and elevated tumor penetration. Mol Pharm, 2014,11(3): 1042-1052. (IF=4.384)\r
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Mei Ling, Zhang Qianyu, Yang Yuting, He Qin, Gao Huile*. Angiopep-2 and activatable cell penetrating peptide dual modified nanoparticles for enhanced tumor targeting and penetrating. Int J Pharm, 2014, 474: 95-102. (IF=3.65)\r
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Gao Huile, Zhang Shuang, Yang Zhi, Cao Shijie, Jiang Xinguo, Pang Zhiqing*. In vitro and in vivo intracellular distribution and anti-glioblastoma effects of docetaxel-loaded nanoparticles functioned with IL-13 peptide. Int J Pharm, 2014, 466(1-2): 8-17.(IF=3.65)\r
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Gao H, Wang Y, Chen C, Chen J, Wei Y, Cao S, Jiang X*. Incorporation of lapatinib into core-shell nanoparticles improves both the solubility and anti-glioma effects of the drug. Int J Pharm, 2014; 461(1-2): 478– 488. (IF=3.65)\r
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Qian Jun#, Ruan Shaobo#, Cao Xi, Cun Xingli, Chen Jiantao, Shen Shun, Jiang Xinguo, He Qin, Zhu Jianhua*, Gao Huile*. Fluorescent carbonaceous nanospheres as biological probe for noninvasive brain imaging. J Colloid Interf Sci, 2014, 436: 227-233. (IF=3.368)\r
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Qian Jun#, Chen Jiantao#, Ruan Shaobo, Shen Shun, He Qin, Jiang Xinguo, Zhu Jianhua*, Gao Huile*. Preparation and biological evaluation of photoluminescent carbonaceous nanospheres. J Colloid Interf Sci, 2014, 429: 77-82. (IF=3.368)\r
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Ruan Shaobo, Zhu Biyue, Zhang Huajin, Chen Jiantao, Shen Shun, Qian Jun, He Qin, Gao Huile*. A simple one-step method for preparation of fluorescent carbon nanospheres and the potential application in cell organelles imaging. J Colloid Interf Sci, 2014,422: 25-29. (IF=3.368)\r
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Gao Huile, Yang Zhi, Zhang Shuang, Pang Zhiqing, Jiang Xinguo*. Internalization and subcellular fate of aptamer and peptide dual-functioned nanoparticles. J Drug Target, 2014, 22(5): 450-459. (IF=2.741)\r
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Zhang Li, Zhang Shuang, Ruan Shaobo, Zhang Qianyu, He Qin, Gao Huile*. Lapatinib incorporated lipoprotein-like nanoparticles: preparation and breast cancer targeting mechanism. Acta Pharmacol Sin, 2014,35(6): 846-852.(IF=2.912)