个人简历

四川大学华西医院生物治疗国家重点实验室学术带头人。2017年科技部中青年科技创新领军人才，四川省学术和技术带头人，教育部新世纪优秀人才基金获得者，四川省杰出青年科学基金获得者。作为课题负责人承担了国家重点研发计划、国家“重大新药创制”科技重大专项、国家“863”重点课题、国家“973”子课题、国家自然科学基金等项目10余项。以第一或通讯作者在Nature Communications, Clin. Cancer Res, Small, Molecular Therapy, J Immunol.等SCI杂志上发表论文54篇, 申请国家发明专利17项，获得授权发明专利10项。

研究领域

从事肿瘤微环境及肿瘤免疫治疗研究，肿瘤相关基因及非编码RNA功能研究，创新生物技术药物和生物治疗产品研发，干细胞治疗的基础与转化研究等，多项细胞治疗产品转化。

近期论文

1. Gang Shi#, Qianmei Yang#, Yujing Zhang#, Qingyuan Jiang, Yi Lin, Shenshen Yang, Huiling Wang, Lin Cheng,Xin Zhang, Yimin Li, Qingnan Wang, Yi Liu,Qin Wang, Hantao Zhang, Xiaolan Su,Lei Dai, Lei Liu, Shuang Zhang, Jia Li, Zhi Li, Yang Yang,Dechao Yu, Yuquan Wei, Hongxin Deng*. Modulating tumour microenvironment via oncolytic virus and CSF-1R inhibition synergistically enhances anti-PD-1 immunotherapy. Molecular Therapy. 2019 Jan 2;27(1):244-260. (通讯作者) 2. Qin Wang#, Lei Dai#*, Yuan Wang, Jie Deng, Yi Lin, Qingnan Wang, Chao Fang, Zida Ma,Huiling Wang, Gang Shi, Lin Cheng, Yi Liu, Shuang Chen, Junshu Li, Zhexu Dong, Xiaolan Su, Lie Yang, Shuang Zhang, Ming Jiang, Meijuan Huang, Yang Yang, Dechao Yu, Zongguang Zhou, Yuquan Wei, Hongxin Deng*. Targeted demethylation of the SARI promotor impairs colon tumour growth. Cancer Letters. 2019.448：132-143 (通讯作者) 3. Lei Dai#, Junshu Li#, Zhexu Dong, Yi Liu, Ye Chen, Na Chen, Lin Cheng,Chao Fang, Huiling Wang, Yanhong Ji, Shuang Chen, Xiaolan Su, Gang Shi,Yi Lin, Shuang Zhang, Yang Yang, Meng Qiu, Dechao Yu, Wei Huang, Zongguang Zhou, Yuquan Wei, Hongxin Deng*.Temporal expression and functional analysis of long noncoding RNAs in colorectal cancer initiation and progression. J. Cell. Mol. Med.2019 (通讯作者) 4. Yuan Wang†, Ying Mao†, Junfeng Zhang, Gang Shi, Lin Cheng, Yi Lin, Yiming Li, Xiaomei Zhang, Yujing Zhang, Xiaolei Chen, Jie Deng, Xiaolan Su, Lei Dai, Yang Yang, Shuang Zhang, Dechao Yu, Yuquan Wei, Hongxin Deng*.IL-35 recombinant protein reverses inflammatory bowel disease and psoriasis through regulation of inflammatory cytokines and immune cells.J. Cell. Mol. Med. 2018 Feb;22(2):1014-1025. (通讯作者) 5. Chunlei Li #, Lei Dai#, Junfeng Zhang #, Yujing Zhang #, Yi Lin, Lin Cheng, Hongwei Tian, Xin Zhang, Qingnan Wang, Qianmei Yang, Yuan Wang, Gang Shi, Fuyi Cheng, Xiaolan Su, Yang Yang, Shuang Zhang, Dechao Yu, Yuquan Wei, Hongxin Deng*. Follistatin-like protein 5 inhibits hepatocellular carcinoma progression by inducing caspase-dependent apoptosis and regulating Bcl-2 family proteins. J. Cell. Mol. Med. 2018 Dec;22(12):6190-6201. (通讯作者) 6. Fuyi Cheng#,Yujing Zhang#,Yuan Wang#, Qingyuan Jiang, Cheng jian Zhao, Jie Deng, Xiaolei Chen, Yunqi Yao, Zhemin Xia, Xiaolan Su, Lin Cheng, Lei Dai,Gang Shi,Yang Yang, Shuang Zhang, Dechao Yu, Yuquan Wei, Hongxin Deng*. Conversion of Human Adipose-Derived Stem Cells into Functional and Expandable Endothelial-Like Cells for Cell-Based Therapies Stem Cell Research Therapy. 2018 Dec 17;9(1):350. doi: 10.1186/s13287-018-1088-6 (通讯作者) 7. Yuan Wang†, Junli Liu†, Qingyuan Jiang†, Jie Deng, Fen Xu, Xiaolei Chen, Fuyi Cheng,Yujing Zhang, Yunqi Yao, Zhemin Xia, Xia Xu, Xiaolan Su, Meijuan Huang, Lei Dai,Yang Yang, Shuang Zhang, Dechao Yu, Robert Chunhua Zhao, Yuquan Wei, Hongxin Deng*. Human adipose-derived mesenchymal stem cell-secreted CXCL1 and CXCL8 facilitate breast tumor growth by promoting angiogenesis. Stem cells. 2017 Sep;35(9):2060-2070. (通讯作者) (封面文章，cover image） 8. Hong-xin Deng, Yuan Wang, Qiu-rong Ding, Da-li Li, and Yu-quan Wei. Gene therapy research in Asia..Gene Therapy. 2017 Sep;24(9):572-577. 9. Lin Cheng, Qianmei Yang, Can Li, Lei Dai, Yang Yang, Qingnan Wang, Yu Ding, Junfeng Zhang, Lei Liu, Shuang Zhang, Ping Fan, Xun Hu, Rong Xiang, Dechao Yu, Yuquan Wei, and Hongxin Deng*. DDA1, a novel oncogene, promotes lung cancer progression through regulation of cell cycle. J. Cell. Mol. Med.2017 Aug; 21(8): 1532-1544. 10. Xiao-mei Zhang,Yu-jing Zhang,Wei Wang, Yu-quan Wei and Hong-xin Deng*. Mesenchymal Stem Cells to Treat Crohn's Disease with Fistula. Human Gene Therapy. 2017 Jul;28(7):534-540. (通讯作者) 11. Lei Dai, Xueliang Cui, Xin Zhang, Lin Cheng, Yi Liu, Yang Yang, Ping Fan, Qingnan Wang, Yi Lin, Junfeng Zhang, Chunlei Li, Ying Mao, Qin Wang,Xiaolan Su, Shuang Zhang,Yong Peng, Hanshuo Yang, Xun Hu, Jinliang Yang, Meijuan Huang, Rong Xiang, Dechao Yu, Zongguang Zhou, Yuquan Wei, Hongxin Deng*. SARI inhibits angiogenesis and tumor growth of human colon cancer through directly targeting ceruloplasmin Nature Communications. 2016. Jun 29;7:11996. doi: 10.1038/ ncomms11996.（通讯作者） 12. Fen Xu, Tianyi Kang, Jie Deng, Junli Liu, Liang Ouyang, Xiaolei Chen, Yuan Wang, Ting Du, Hong Tang, Xiaoping Xu, Shaochen Chen, Yanan Du, Zhiyong Qian, Yuquan Wei, Hongxin Deng* and Maling Gou*. Functional Nanoparticles Activate a Decellularized Liver Scaffold for Blood Detoxification Small. 2016 Apr;12(15):2067-76 (通讯作者） 13. Junfeng Zhang, Yi Lin, Chunlei Li, Xiaomei Zhang, Lin Cheng, Lei Dai, Youcui Wang, Fangfang Wang，Gang Shi, Xueliang Cui, Yi Liu, Qianmei Yang, HuiLing Wang, Shuang Zhang, Yang Yang, Rong Xiang, Jiong Li, Dechao Yu, Yuquan Wei, Hongxin Deng*. IL-35 decelerates the inflammatory process by regulating inflammatory cytokine secretion and M1/M2 macrophages ratio in psoriasis. J Immunol. 2016.197: 2131-2144.（通讯作者） 14. Yanli Fu, Jie Deng, Qinyuan Jiang,Yuan Wang, Yujing Zhang, Yunqi Yao, Fuyi Cheng, XiaoLei Chen, Fen Xu, Meijuan Huang, Yang Yang, Zhang Shuang, Dechao Yu, Robert Chunhua Zhao, Yuquan Wei and Hongxin Deng*.Rapid Generation of Functional Hepatocyte-like Cells from Human Adipose-Derived Stem Cells. 2016. Stem Cell Res. Thera. 2016,7:105 DOI 10.1186/ s13287-016-0364-6 （通讯作者） 15. Hongwei Tian, Gang Shi, Qin Wang, Yiming Li, Qianmei Yang, Chunlei Li，Guoyou Yang, Min Wu, Qian Xie, Shuang Zhang, Yang Yang, Rong Xiang, Dechao Yu, Yuquan Wei, Hongxin Deng*. A novel cancer vaccine with the ability to simultaneously produce anti-PD-1 antibody and GM-CSF in cancer cells and enhance Th1-biased antitumor immunity. Signal Transduction and Targeted Therapy.(2016).1, 16025; doi:10.1038/sigtrans.2016.25. (通讯作者) 16. Fen Xu, Junli Liu, Jie Deng, Xiaolei Chen, Yuan Wang, Pengchao Xu, Lin Cheng, Yanli Fu, Fuyi Cheng, Yunqi Yao, Yujing Zhang, Meijuan Huang, Dechao Yu, Yuquan Wei, and Hongxin Deng*. Rapid and High-Efficiency Generation of Mature Functional Hepatocyte-like Cells from Adipose-Derived Stem Cells by a Three-Step Protocol. Stem Cell Res. Thera. 2015 Oct 5;6:193. doi: 10.1186/s13287-015-0181-3（通讯作者） 17. Hongwei Tian, Gang Shi,Guoyou Yang,Junfeng Zhang, Yiming Li, Tao Du, Jianzhou Wang, Fen Xu, Lin Cheng, Xiaomei Zhang, Lei Dai, Xiaolei Chen, Shuang Zhang, Yang Yang, Dechao Yu, Yuquan Wei, Hongxin Deng*.Cellular immunotherapy using irradiated lung cancer cell vaccine co-expressing GM-CSF andIL-18 can induce significant antitumor effects. BMC Cancer. 2014 Jan 29;14:48. doi: 10.1186/ 1471- 2407-14-48. (通讯作者) 18. Du T, Shi G, Li YM, Zhang JF, Tian HW, Wei YQ, Deng H*, Yu DC*.Tumor-specific Oncolytic Adenoviruses Expressing Granulocyte Macrophage Colony-Stimulating Factor or Anti-CTLA4 Antibody for the Treatment of Cancers. Cancer Gene Thera. 2014; 21(8):340-8 (通讯作者）