研究领域

1、抗神经退行性疾病药物研究 2、抗肿瘤药物研究 3、药物合成工艺及产业化研究

近期论文

1、Design, synthesis and evaluation of scutellarein-O-acetamidoalkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer’s disease. Eur. J. Med. Chem. 2017, 135, 307-323. 2、Pyridoxine-Resveratrol hybrids mannich base derivatives as novel dual inhibitors of AChE and MAO-B with antioxidant and metal-chelating properties for the treatment of Alzheimer’s disease. Bioorg. Chem. 2017, 71, 305-314. 3、Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer’s disease. Bioorg. Med. Chem. 2017, 25, 1997-2009. 4、Aurone mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggregation and neuroprotective properties for the treatment of Alzheimer's disease. Eur. J. Med. Chem. 2017, 126, 762-775. 5、DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer’s therapy. Bioorg. Med. Chem. Lett. 2017, 27, 718-722. 6、Multitarget drug design strategy against Alzheimer’s disease: homoisoflavonoid mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties. Bioorg. Med. Chem. 2017, 25, 714-726. 7、Design, synthesis and biological evaluation of 4’-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's diseas. Bioorg. Med. Chem. 2017, 25, 1030-1041. 8、Scaffold hopping toward agomelatine: novel 3, 4-dihydroisoquinoline compounds as potential antidepressant agents. Sci. Rep., 2016, 6, 34711. 9、Synthesis and evaluation of 4-hydroxyl aurone derivatives as multifunctional agents for the treatment of Alzheimer’s disease. Bioorg. Med. Chem. 2016, 24, 2342-2351. 10、Pterostilbene-O-acetamidoalkylbenzylamines derivatives as novel dual inhibitors of cholinesterase with anti-β-amyloid aggregation and antioxidant properties for the treatment of Alzheimer’s disease. Bioorg. Med. Chem. Lett. 2016, 26, 2035-2039. 11、二盐酸沙丙蝶呤的合成. 中国医药工业杂志, 2016, 832-834. 12、奥贝胆酸及其有关物质的合成. 中国医药工业杂志, 2016, 376-379. 13、Design, synthesis, and biological evaluation of scutellarein carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer's disease. Chem. Bio. Drug Des. 2015, 86, 1168-1177. 14、利伐沙班的合成. 中国医药工业杂志, 2015, 442-445. 15、Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease. Eur. J. Med. Chem. 2015, 94, 348-366. 16、Design, synthesis and evaluation of chromone-2-carboxamido-alkylbenzylamines as multifunctional agents for the treatment of Alzheimer’s disease. Bioorg. Med. Chem. 2015, 23, 911-923. 17、Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer’s disease. Bioorg. Med. Chem. 2015, 23, 668-680.