个人简历
在四川大学生物系生物化学专业获学士学位(1985年)和理学硕士学位（1988年）。 2001年四川大学获理学博士学位。 1988年7月四川大学生物系助教、讲师；1993年5月副教授；1995年11月至今教授 2003-2004美国特拉华大学、波士顿大学访问学者。
研究领域
光合蛋白结构与功能 、生物信息学 、肿瘤抑制蛋白的结构与功能
近期论文
1. Lyu Lei, Whitcomb Elizabeth A., Jiang Shuhong, Chang Min-Lee, Gu Yumei, Duncan Melinda K., Cvekl Ales, Wang Wei-Lin, Limi Saima, Reneker Lixing W., Shang Fu, Du Linfang*, Allen Taylor*.Unfolded-protein response-associated stabilization of p27 (Cdkn1b) interferes with lens fiber cell denucleation leading to cataract. FASEB J. 2016, 30:1087-1095. (SCI, IF=5. 22) 2. Zhu Guo-fei, Wang Yu, Xi Lei, Liu Jin, Wang Hao, Du Lin-fang* Spectroscopy and molecular docking studies on the binding of propyl gallate to human serum albumin., Journal of Luminescence, 2015, 159: 188–196. (SCI, IF=2. 69) 3. Han Yong-Guang, Tan Qiu-Ju, Liu Ke, Liu Yang, Du Lin-Fang* Mercuric chloride damages the thylakoid membrane structure of chloroplasts and alters the profiles of SOD, CAT and EST isozymes in Chlamydomonas reinhardtii. Fresenius Environmental Bulletin, 2015, 24: 676-682. (SCI, IF=0. 37) 4. Wang Jing-Zhang, Xi Lei, Lin Tao, Wang Yu, Zhu Guo-Fei, Du Lin-Fang* The structural and functional role of the three tryptophan residues in Pin1.. Journal of Photochemistry and Photobiology B: Biology 2015, 146: 58–67. (SCI, IF=3. 03) 5. Xiao QJ, Li ZG, Yang J, He Q, Xi L, Du LF* Heat-induced unfolding of apo-CP43 studied by fluorescence spectroscopy and CD spectroscopy.. Photosynth Res. 2015, 126: 427-435. (SCI, IF=4. 12) 6. Wang Y, Zhao M, Zhang Q, Zhu GF, Li FF, Du LF* Genomic distribution and possible functional roles of putative G-quadruplex motifs in two subspecies of Oryza sativa. Comput Biol Chem. 2015, 56:122-130. (SCI, IF=1. 01) 7. Qie Beibei, Lyu Zhou, Lyu Lei, Liu Jun, Gao Xuejie, Liu Yanyan, Wei Duan, Zhang Nianhui, Du Linfang*, Liu Ke*. Sch9 regulates intracellular protein ubiquitination by controlling stress responses. Redox Biol. 2015, 5:290-300. (SCI, IF=6. 24) 8. Zhu Guo-Fei, Ren Si-Yan, Xi Lei, Du Lin-Fang*, Zhu Xiao-Feng*, Temperature induced structural transitions from native to unfolded aggregated states of tobacco etch virus protease. J Mol Struct 2015, 1082: 80–90. (SCI, IF=1. 78) 9. Yao Jie, Wu Jibing, Yang Xue, Yang Jiaxi, Zhang Yuxing, and Du Linfang*, Oleuropein Induced Apoptosis in HeLa Cells via a Mitochondrial Apoptotic Cascade Associated With Activation of the c-Jun NH2-Terminal Kinase. J Pharmacol Sci 2014, 125: 300–311. (SCI, IF=2. 36) 10. Wang Yu, Xi Lei, Yao Jie, Yang Jiao, Du Lin-Fang *. Role of pH in structural changes for Pin1 protein: an insight from molecular dynamics study. J Mol Model, 2014, 20: 2376 (SCI, IF=1. 79) 11. Liu Ji, Xie Si-Si, Luo Yue, Zhu Guo-Fei, Du Lin-Fang *. Soluble expression of Spinach psbC gene in Escherichia coli and in vitro reconstitution of CP43 coupled with chlorophyll a only. Plant Physiol Biochem. 2014, 79:19-24. (SCI, IF=2. 10) 12. Han Yongguang, Luo Yue, Qin Shirong, Xi Lei, Wan Bo, Du Linfang *, Induction of systemic resistance against tobacco mosaic virus by Ningnanmycin in tobacco. Pesticide Biochemistry and Physiology. 2014, 111:14-18. (SCI, IF=2. 01) 13. Zhu Guo-fei, Wang Yu, Liu Jin, Wang Hao, Xi Lei, Du Lin-fang * Interaction Between Ginkgolic Acid and Human Serum Albumin by Spectroscopy and Molecular Modeling Methods.. J Solution Chem, 2014, 43:1232-1249 (SCI, IF=1. 17) 14. Wang Jing-Zhang, Liu Ji, Lin Tao, Han Yong-Guang, Luo Yue, Xi Lei, Du Lin-Fang*. Aluminum (III) interferes with the structure and the activity of the peptidyl-prolyl cis-trans isomerase (Pin1): A new mechanism contributing to the pathogenesis of Alzheimer's disease and cancers? Journal of Inorganic Biochemistry, 2013, 126: 111-117 (SCI, IF=3. 27) 15. Yang Xue, Yao Jie, Luo Yue, Han Yong-guang, Wang Zuo-bai, and Du Linfang*, P38 MAP kinase mediates apoptosis after genipin treatment in non–small-cell lung cancer H1299 cells via a mitochondrial apoptotic cascade. J Pharmacol Sci. 2013, 121: 272-281(SCI, IF=2. 11) 16. Wang Yu, Zhu Guo-Fei, Ren Si-Yan, Han Yong-Guang, Luo Yue, Du Lin-Fang*. Insight into the structural stability of wild type and mutants of the tobacco etch virus protease with molecular dynamics simulations. J Mol Model, 2013, 19:4865-4875 (SCI, IF=2. 10) 17. Wang Jing-Zhang, Ren Si-Yan, Zhu Guo-Fei, Xi Lei, Han Yong-Guang, Luo Yue, Du Lin-Fang*, Hg2+ interference with the structure of tobacco etch virus protease (TEVp) and its implications for biological engineering. J Mol Struct 2013, 1052: 85-92. (SCI, IF=1. 60) 18. Wang Jing-Zhang, Li Shu-Rui, Li Ya-Li, Zhang Yong-Ze, Zhang Ting, Zhao Chao-Xian, Yao Chun-Xia, Du Lin-Fang*, Could Pin1 help us conquer essential hypertension at an earlier stage? A promising early-diagnostic biomarker and its therapeutic implications for the disease. Medical Hypotheses, 2013, 81: 931-935. (SCI, IF=1. 15)
