个人简历

1986年毕业于华西医科大学药学院药学专业获理学学士学位，1989年毕业于华西医科大学药理学专业获理学硕士学位，2006年毕业于香港理工大学生物学专业获理学博士学位。1997～1998年荷兰莱顿大学TNO研究机构Gaobius实验室访问学者。1989年以来四川大学华西药学院药理学系任讲师、副教授、教授。

研究领域

1.心脑血管药理学与创新药物研究 2.抗肿瘤靶向药物的药理学研究 3.口腔药物及健康产品研发

近期论文

1.Zhou HJ, Li H, Shi MQ, Mao XN, Liu DL, Chang YR, Gan YM, Kuang X, Du JR*. Protective Effect of Klotho against Ischemic Brain Injury Is Associated with Inhibition of RIG-I/NF-κB Signaling. Frontiers in Pharmacology. 2018; 8:950:962. 2.Long FY, Shi MQ, Zhou HJ, Liu DL, Sang N, Du JR*. Klotho upregulation contributes to the neuroprotection of ligustilide against cerebral ischemic injury in mice. European Journal of Pharmacology. 2018; 820:198-205. 3.Zhou HJ, Zeng CY, Yang TT, Long FY, Kuang X, Du JR*. Lentivirus-mediated klotho up-regulation improves aging-related memory deficits and oxidative stress in senescence-accelerated mouse prone-8 mice. Life Sciences. 2018; 200:56-62. 4.Han L, Liu DL, Zeng QK, Shi MQ, Zhao LX, He Q, Kuang X, Du JR. The neuroprotective effects and probable mechanisms of Ligustilide and its degradative products on intracerebral hemorrhage in mice. International Immunopharmacology. 2018;63: 43- 57. 5.Kuang X, Zhou HJ, Thorne AH, Chen XN, Li LJ, Du JR*. Neuroprotective Effect of Ligustilide through Induction of α-Secretase Processing of Both APP and Klotho in a Mouse Model of Alzheimer's Disease. Frontiers in Aging Neuroscience. 2017; 9: 353-366. 6.Liu DL, Zhao LX, Zhang S, Du JR*.Peroxiredoxin 1-mediated activation of TLR4/NF-κB pathway contributesto neuroinflammatory injury in intracerebral hemorrhage. International Immunopharmacology 2016;41:82–89. 7.Zhao LX, Du JR*, Zhou HJ, Liu DL, Gu MX, Long FY. Differences in proinflammatory property of six subtypes of peroxiredoxins and anti-inflammatory effect of ligustilide in macrophages. PLOS ONE. 2016;11(10):e0164586. 8.Wang PH, Zhao LX, Wan JY, Zhang L, Mao XN, Long FY, Zhang S, Chen C, Du JR*. Pharmacological characterization of a novel gastrodin derivative as a potential anti-migraine agent.Fitoterapia. 2016;109:52-57. 9.Zeng Y, Wang PH, Zhang Mao, Du JR*. Aging-related renal injury andinflammation are associated with downregulation of Klotho and induction of RIG-I/NF-κB signaling pathway in senescence-accelerated mice. Aging Clin Exp Res. 2015; 28(1):69-76. 10.Long FY, Chen YS, Zhang L, Kuang X, Yu Y, Wang LF, Liu XJ, Wang L,Zhou YF, Sang N, Du JR*. Pennogenylsaponins induce cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. J Ethnopharmacol. 2015;162:112-120. 11.Li YJ, Li XH, Wang LF, Kuang X, Hang ZX, Deng Y, Du JR*. Therapeutic efficacy of a novel non-peptide αvβ3 integrin antagonist for pathological retinal angiogenesis in mice. Exp Eye Res 2014;129:119-126. 12.Du JR*, Long FY, Chen C. The Enzymes, Volume 36, Chapter 6: Research Progress on Natural TriterpenoidSaponins in the Chemoprevention and Chemotherapy of Cancer. P96-134, ELSEVIER, 2014. (Invited Review) 13.Kuang X, Chen YS, Wang LF, Li YJ, Liu K, Zhang M, Li L, Chen C,He Q, Wang Y, Du JR*. Klothoupregulation contributes to the neuroprotection of ligustilide in an Alzheimer's disease mouse model. Neurobiol Aging. 2014;35(1):169-178. 14.Kuang X, Wang LF, Yu L, Li YJ, Wang YN, He Q, Chen C, Du JR*.Ligustilide ameliorates neuroinflammation and brain injury in focal cerebral ischemia/reperfusion rats: involvement of inhibition of TLR4/peroxiredoxin 6 signaling. Free RadicBiol Med. 2014;71C:165-175. 15.Chen YS, He Y, Chen C, Zeng Y, Xue D, Wen F, Wang L, Zhang H, Du JR*.Growth inhibition by pennogenylsaponins from Rhizomaparidis on hepatomaxenografts in nude mice. Steroids. 2014;83:39-44. 16.Han L, Lai P, Du JR*. Deciphering molecular mechanism underlying hypolipidemic activity of echinocystic Acid. Evid Based Complement Alternat Med. 2014;2014:823154.