个人简历

教育经历 1996.9-2000.7 南京大学学士 2000.9-2003.11 南京大学硕士研究生 2004.2-2008.11 美国宾夕法尼亚大学 博士 2008.11-2013.6 霍华德休斯研究所/康奈尔大学 博士后 2013.7-2015.11 美国康奈尔大学助理教授 2015.11-至今四川大学华西附二院/生物治疗国家重点实验室 特聘研究员

研究领域

1）血管内皮细胞是如何通过与组织干细胞及成纤维细胞相互作用调控器官的再生和纤维化反应。2）血液细胞如血小板和免疫细胞是怎样与血管系统共同形成“血液和血管微环境”，从而控制受损器官的再生和纤维化。3)是否可通过编辑血液和血管细胞建立“促再生和抗纤维化的微环境”，从而增强干细胞在病变器官的功能性植入，达到促进组织再生的治疗目的。

近期论文

1. Cao Z*, Lis R, Ginsburg M, Chavez D, Shido K, Rabbany SY, Fong GH, Sakmar TP, Rafii S*, Ding BS*. Targeting of pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis. Nature Medicine 2016, 22(2):154-62 (Journal Cover) (*Corresponding author). PMID 26779814 Highlighted in 1) Science Signaling 2016, 9(415):ec31; 2) Nature Review of Drug Discovery 2016, 2016 Feb 26. doi: 10.1038/nrd.2016.25. 2. Rafii S*, Butler JM*, Ding BS*. Angiocrine functions of organ-specific endothelial cells Nature 2016, 529(7586):316-25. (*Corresponding author). PMID26791722 3. Rafii S, Cao Z, Lis R, Chavez D, Shido K, Rabbany SY, Ding BS*. Platelet-derived SDF-1 primes the pulmonary capillary vascular niche to drive lung alveolar regeneration. Nature Cell Biology 2015, 17(2):123-36. (*Corresponding author). PMID 25621952. 4. Ding BS*, Cao Z, Lis R, Nolan DJ, Guo P, Simons M, Penfold M, Shido K, Rabbany SY, and Rafii, S*. Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis. Nature 2014, 505(7481):97-102. (ePub 2013 Nov 20) (* Corresponding author). PMID 24256728 Highlighted in 1) Science Signaling 2014, 7(307):ec7; 2) F1000 Prime (article 718183961); 3) Science Translational Medicine 2014, 6(224):ec33. 4) Hepatology 2014, doi:10.1002 /hep.27116. 5. Cao Z, Ding BS*, Guo P, Lee SL, Butler JM, Casey SC, Simons M, Tam W, Felsher DW, Shido K, Scandura JM, Rafii, S*. Angiocrine signals from tumor vascular niche induce B-Cell lymphoma invasiveness and chemoresistance. Cancer Cell 2014, 25(3): 1-16. (* Corresponding author). PMID 24651014 Highlighted in 1) Cancer Cell 2014, 25 (3), 261–263; 2) Nature Reviews Cancer 14, 298 (2014) doi:10.1038/nrc3730; 3) Science Signaling 2014, 7 (319): p. ec85. 6. Ding BS, Nolan DJ, Guo P, Babazadeh AO, Cao Z, Rosenwaks Z, Sato TN, Shido K, Rabbany SY, Rafii S. Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization. Cell 2011, 147:539-553. PMID 22036563 Highlighted in Cell 2011, 147(3):485-7. 7. Ding BS, Nolan DJ, Butler JM, James D, Babazadeh AO, Rosenwaks Z, Mittal V, Kobayashi H, Shido K, Lyden D, Sato TN, Rabbany SY, & Rafii S. Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration. Nature 2010; 468(7321):310-5. PMID 21068842 Highlighted in 1) Journal of Hepatology 2011, 55(2):488-90; 2) Hepatology 2011;54(2):731-3. 3) Faculty of 1000 Biology (article 6577956). 8. Ding BS, Gomi K, Rafii S, Crystal RG, Walters MS. Endothelial MMP14 is required for endothelial-dependent growth support of human airway basal cells. J. Cell Sci. 2015 Aug 15;128(16):2983-8. PMID 26116571 9. Ding BS, James D, Iyer R, Falciatori I, Hambardzumyan D, Wang S, Butler JM, Rabbany SY, Hormigo A. Prominin 1/CD133 endothelium sustains growth of proneural glioma. PLoS One. 2013 Apr 25;8(4):e62150. PMID 23637986 10. Curradi G#, Walters MS#, Ding BS#, Rafii S, Hackett NR, Crystal R. Airway basal cell vascular endothelial growth factor-mediated cross-talk regulates endothelial cell-dependent growth support of human airway basal cells. Cellular and Molecular Life Sciences 2012 (ePub) (#contributed equally). PMID 22382924 11. Ding BS, Hong N, Christofidou-Solomidou M, Gottstein C, Albelda SM, Cines DB, Fisher AB, Muzykantov VR. Anchoring Fusion thrombomodulin to the Endothelial Lumen Protects Injury-Induced Lung Thrombosis and Inflammation. American Journal of Respiratory and Critical Care Medicine2009;180(3):247-56. PMID 19342415 12. Ding BS, Hong N, Murciano JC, Ganguly K, Gottstein C, Christofidou-Solomidou M, Albelda SM, Fisher AB, Cines DB, Muzykantov VR. Prophylactic thrombolysis by thrombin-activated latent pro-urokinase targeted to PECAM-1 in the pulmonary vasculature. Blood 2008; 111(4):1999-2006. PMID 18045968 13. Ding BS, Dziubla T, Shuvaev VV, Muro S, Muzykantov VR. Advanced drug delivery systems that target the vascular system. Molecular Intervention2006; 6: 98-112. PMID 16565472 14. Ding BS, Gottstein C, Grunow A, Kuo A, Ganguly K, Albelda SM, Cines DB, Muzykantov VR. Endothelial targeting of a recombinant construct fusing a PECAM-1 scFv with pro-urokinase facilitates prophylactic thrombolysis in the pulmonary vasculature. Blood 2005; 106: 4191-4198. PMID 16144802 15. Ding BS, Zhou YJ, Chen XY, Zhang J, Zhang PX, Tan XY, Liu JN. Lung Endothelium Targeting for Pulmonary Embolism Thrombolysis. Circulation (Rapid Track) 2003; 108: 2892-2898. PMID 14610017