个人简历

1985 – 1988:华西医科大学药学院药物化学硕士学位\r
1988 – 1997: 武汉工程大学制药工程系助教、讲师、副教授、教授\r
1996 – 1999: 四川大学有机化学博士学位\r
1995 – 1996: 美国 Washington University 化学系访问学者\r
1996 – 1997: 伦敦大学King's College London生物药学系访问学者\r
1997 –至今: 复旦大学化学系、生物医学研究院教授、博士生导师

研究领域

"""""1. 基于计算机辅助和药物作用机制的新药发现\r
2. 天然产物的化学全合成研究\r
3. 有机小分子不对称催化反应的应用研究\r
4. 手性药物与手性技术的研究\r
5. 药物合成创新工艺的研究"

近期论文

Chen X.F.,XiongF.J., Chen W.X., He Q.Q.,Chen F.E.*, Asymmetric Synthesis of the HMG-CoA Reductase Inhibitor Atorvastatin Calcium: An Organocatalytic Anhydride Desymmetrization and Cyanide-Free Side Chain Elongation Approach.J. Org. Chem.2014,79,2723-2728\r
\r
Xiong F.J., Wang H.F., Yan L.Y., Xu L.J., Tao Y., Wu Y.,Chen F.E.*. Diastereoselective synthesis of pitavastatin calcium via bismuth-catalyzed two-component hemiacetal/oxa-Michael addition reaction.Org. Biomol. Chem.2015, 13, 9813–9819\r
\r
Zheng C., Wang H.F., Chen W.Q., Chen W.X.,Chen F.E.*. Organocatalytic Asymmetric Vinylogous Michael Addition of 3-(2-Oxoindolin-3-ylidene)butanoates to Nitroalkenes Catalyzed by a Bifunctional Cinchona-BasedSquaramide.Asian J. Org. Chem.2015, 4, 619-621\r
\r
Yang H. J.,Xiong F. J., Chen X. F.,Chen F. E.*. Highly Enantioselective Thiolysis of Prochiral Cyclic Anhydrides Catalyzed by Amino Alcohol Bifunctional Organocatalysts and Its Application to the Synthesis of Pregabalin.Eur. J. Org.Chem..2013,4495-4498\r
\r
Dai L., Yang H.J.,Chen F.E.*. Chiral Squaramide-Catalyzed Enantioselective Conjugate Michael Addition of Various Thiols to alpha,beta-UnsaturatedN-Acylated Oxazolidin-2-ones.Eur. J. Org. Chem.2011,5071-5076\r
\r
Wan Z.Y., Yao J., Mao T.Q., Wang X.L., Wang H.F., Chen W.X., Yin H.,Chen F.E.*, De Clercq, E., Daelemans D.,Pannecouque, C.. Pyrimidine sulfonylacetanilides with improved potency against key mutant viruses of HIV-1 by specific targeting of a highly conserved residue.Eur. J. Org. Chem.2015, 12, 215-222\r
\r
Wan Z.Y., Yao J., Tao Y., Mao T.Q., Wang X.L., Lu Y.P., Wang H.F., Yin H., Wu Y.,Chen F.E.*, De Clercq, E., Daelemans D., Pannecouque, C..Discovery of piperidin-4-yl-aminopyrimidine derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.Eur. J. Org. Chem.2015, 97, 1-9\r
\r
Gu S.X., Li Z.M., Ma X.D., Yang S.Q., He Q.Q.,Chen F.E.*, De Clercq, E., Balzarini, J., Pannecouque, C..Chiral resolution, absolute configuration assignment and biological activity of racemic diarylpyrimidineCH(OH)-DAPY as potent nonnucleoside HIV-1 reverse transcriptase inhibitors.Eur. J. Med. Chem.2012,53,229-234\r
\r
Ma X.D., He Q.Q., Zhang X., Yang S.Q., Yang L.M., Gu S.X., Zheng Y.T.,Chen F.E.*, Dai H.F..Synthesis, structureeactivity relationships, and docking studies of N-phenylarylformamide derivatives (PAFAs) as non-nucleoside HIV reverse transcriptase inhibitors.Eur. J. Med. Chem.2012,58,504-512\r
\r
Yang S.Q., Pannecouque, C., Daelemans D., Ma X.D., Liu Y.,Chen F.E.*, De Clercq, E.. Molecular design, synthesis and biological evaluation of BP-O-DAPY and O-DAPY derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors.Eur. J. Med. Chem.2013,65,134-143\r
\r
MengG., Liu Y., Zheng A.Q.,Chen F.E.*, Chen W.X., De Clercq E.,Pannecouque C., BalzariniJ.Design and synthesis of a new series of modified CH-diarylpyrimidines as drug-resistant HIV non-nucleoside reverse transcriptase inhibitors.Eur. J. Med. Chem.2014,82,600-611\r
\r
Liang Y. H., Feng X. Q., Zeng Z. S.,Chen F. E.*,Balzarini J.,Pannecouque C., De Clercq E.. Design ，Synthesis, and SAR of Naphthyl-Substituted Diarylpyrimidines as Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase.Chem. Med. Chem.2009,4,1537-1545\r
\r
He Q. Q., Zhang X., Wu H. Q.,Gu S. X., Ma X. D., Yang L. M., Zheng Y. T.,Chen F. E.*, Synthesis and biological evaluation of HQCAs with aryl or benzyl substituents onN-1 position as potential HIV-1 integrase inhibitors.Bioorg.& Med. Chem.2011,19,5553-5558\r
\r
Wang Y. P.,Chen F. E.*, De Clercq E.,Balzarini J.,Pannecouque C., Synthesis and biological evaluation of novel 6-substituted 5-alkyl-2-(arylcarbonylmethylthio) pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.Bioorg. & Med. Chem.2008,16,3887-3894\r
\r
Wu H. Q., Yan Z. H., Chen W. X., He Q. Q.,Chen F. E.*, De ClercqE., Balzarini J., DaelemansD., Pannecouque C.. Towards new C6-rigid S-DABO HIV-1 reverse transcriptase inhibitors: Synthesis, biological investigation and molecular modeling studies.Bioorg. & Med. Chem.2013,21,6477-6483\r
\r
Wang Z. H., Li F., Zhao L., He Q. Q.,Chen F. E.*, Zheng, C., An efficient enantioselective synthesis of florfenicol via asymmetric aziridination.Tetrahedron2011,67,9199-9203\r
\r
ChenX.F.,XiongF. .J., Zheng C., LiJ.,Chen F.E.*. studies on statins. Part 3: A facile synthesis of rosuvastatin calcium through catalytic enantioselective allylation strategy.Tetrahedron2014,70,5794-5799\r
\r
Zhao L., Ma X. D.,Chen F. E.*. Development of Two Scalable Syntheses of 4-Amino-5-aminomethyl-2-methylpyrimidine: Key Intermediate for Vitamin B-1.Org. Process Res. Dev.2012,16,57-60\r
\r
Li F., Wang Z. H., Zhao L.,Chen F. E.*, A Facile and Efficient Asymmetric Synthesis of Florfenicol.Synlett2011,19,2883-2885\r
\r
Dai L., Yang H. J.,Niu J. Z.,Chen F. E*. Enantioselective Protonation in the Sulfa-Michael Addition Using Chiral Squaramides as Hydrogen-Bonding Organocatalysts.Synlett2012,23, 314-316\r
\r
Xiong F., Chen X. X., Liu Z. Q.,Chen F. E*. A novel synthetic strategy for the stereospecific total synthesis of (+/-)-biotin.Tetrahedron Lett.2010,5,3670-3672