个人简历

1990-1994 天津南开大学化学系有机化学专业 本科\r
1994-1997 华西医科大学药学院药物化学专业 硕士研究生\r
1998-2001 中科院成都有机化学研究所有机化学专业 博士研究生\r
2001-2002 中科院成都有机化学研究所 博士后研究\r
2002-2003 香港大学化学系 博士后研究\r
2003-至今　四川大学华西药学院 教授、博士生导师\r
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获奖情况\r
1. 2007年 四川省第九届青年科技奖\r
2. 2007年 药明康德生命化学研究奖（三等）\r
3. 2011四川省有突出贡献的优秀专家\r
4. 2011年国家杰出青年科学基金\r
5. 2012 Thieme Journal Award\r
6. 2012 Asia Core Program Lectureship Award\r
7. 2013年全国百篇优秀博士学位论文指导教师\r
8. 2014年中国化学会青年手性化学奖\r
9. 2014年科技部科技创新人才推进计划青年领军人才\r
10. 2015年四川省卫生计生领军人才

研究领域

"""""主要从事新型手性催化剂的设计、合成及不对称催化反应研究以及生理活性物质的设计、合成等方面的工作。重点在手性有机小分子以及金属配合物催化的不对称合成领域开展研究并获得了系列成果：\r
1）在基于氢键活化的手性硫脲等催化剂的设计及其促进的不对称反应进行了多方面研究，建立了结构、功能多样的基于氢键活化的有机催化剂库，在多种不对称催化反应中实现了好的立体控制，发展了多种重要手性中间体、特别是非天然氨基酸的不对称合成方法。\r
2）在手性伯、仲胺通过烯胺、二烯胺、三烯胺及亚胺盐机制催化饱和或不饱和醛和酮以及叔胺、叔膦等作为Lewis碱催化Morita-Baylis-Hillman产物碳酸酯的不对称转化反应等领域开展了系统的研究，在催化剂、催化机制及新型催化反应的设计等多方面进行了积极探索。\r
3）致力于新颖的硫酚/手性胺、硫酚/手性相转移以及硫酚/有机膦等共催化体系的发展，实现了多类具挑战性的不对称反应的区域、化学以及立体选择性的高效调控。\r
4）探索新型的Lewis碱/金属配合物协同催化体系，进一步拓展了叔膦/叔胺等Lewis碱催化的应用范围。\r
5）建立发展基于金属钯p-Lewis碱配合物催化的新型反应途径。\r
6）课题组发展了数十种多官能团、多手性中心化合物的合成新方法，建立数千个新型化合物库；通过计算机辅助和细胞筛选实验，发现多类新颖的抗肿瘤、抗肺纤维化等新结构物质，为进一步发现和设计新型生理活性手性化合物奠定坚实基础。"

近期论文

Jian-Xiang Zhu, Zhi-Chao Chen,* Wei Du, and Ying-Chun Chen,* “Asymmetric auto-tandem palladium catalysis for 2,4-dienyl carbonates: Ligand-controlled divergent synthesis”, Angew. Chem. Int. Ed. 2022, 61, DOI: 10.1002/anie.202200880.\r
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Bao-Xin Liu, Ru-Jie Yan, Wei Du,* and Ying-Chun Chen,* “Solvent-regulated diastereodivergent [3+2] annulations of CF3-containing Morita−Baylis−Hillman carbonates with cyclic sulfonimines”, Chin. J. Chem. 2022, 40, DOI: 10.1002/cjoc.202200003.\r
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Xing-Xing Yang, Xing-Liang Zhao, Qin Ouyang,* Wei Du,* and Ying-Chun Chen,* “Palladium-catalysed diastereodivergent inverse-electron-demand oxa-Diels-Alder reactions of in situ formed cyclopentadienones via ligand-control”, Org. Chem. Front. 2022, 9, DOI: 10.1039/D1QO01876K.\r
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Ze-Liang He, Peng Chen, Zhi-Chao Chen,* Wei Du, and Ying-Chun Chen,* “Construction of hydrodibenzo[b,d]furan frameworks from Morita-Baylis-Hillman carbonates of isatins and ortho-hydroxy enones via palladium and Brønsted base relay catalysis”, Org. Lett. 2022, 24, 100.\r
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Xing-Xing Yang, Ru-Jie Yan, Guang-Yao Ran, Chen Chen, Jing-Fei Yue, Xiao Yan, Qin Ouyang,* Wei Du,* and Ying-Chun Chen,* “p-Lewis-base-catalyzed asymmetric vinylogous umpolung reactions of cyclopentadienones and tropone”, Angew. Chem. Int. Ed. 2021, 60, 26762.\r
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Zhi Chen, Zhi-Chao Chen,* Wei Du, Ying-Chun Chen,* “Asymmetric [4 + 3] annulations for constructing divergent oxepane frameworks via cooperative tertiary amine/transition metal catalysis”, Org. Lett. 2021, 23, 8559.\r
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Qing He, Lei Zhu, Zhen-Hong Yang, Bo Zhu, Qin Ouyang,* Wei Du,* and Ying-Chun Chen,* “Palladium-catalyzed modular and enantioselective cis-difunctionalization of 1,3-enynes with imines and boronic reagents”, J. Am. Chem. Soc. 2021, 143, 17989.\r
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Ru-Jie Yan, Bao-Xin Liu, Yuan Hu, Wei Du,* and Ying-Chun Chen,* “Generation of zwitterionic trifluoromethyl N-allylic ylides and use in switchable divergent annulations”, Chem. Commun. 2021, 57, 9056.\r
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Yue Li, Peng Chen, Zhi-Chao Chen,* Wei Du, Qin Ouyang, Ying-Chun Chen,* “Palladium-catalysed oxidative nucleophilic allylation between alkenes and activated ketimines”, Org. Chem. Front. 2021, 8, 5418.\r
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Yang Yang, Bo Zhu, Lei Zhu, Ying Jiang, Chun-Ling Guo, Jing Gu, Qin Ouyang,* Wei Du,* and Ying-Chun Chen,* “Combining palladium and ammonium halide catalysts for Morita-Baylis-Hillman carbonates of methyl vinyl ketone: from 1,4-carbodipoles to ion pairs”, Chem. Sci. 2021, 12, 11399.\r
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Zhi Zhao, Xing-Xing Yang, Guang-Yao Ran, Qin Ouyang, Wei Du,* and Ying-Chun Chen,* “Ligand-controlled regiodivergent asymmetric [5 + 2] and [3 + 2] annulations of vinyl indoloxazolidones catalyzed by palladium”, Org. Lett. 2021, 23, 4791.\r
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Zhen-Hong Yang, Peng Chen, Zhi-Chao Chen, Zhi Chen, Wei Du,* and Ying-Chun Chen,* “A double deprotonation strategy for cascade annulations of palladium-trimethylenemethanes and Morita-Baylis-Hillman carbonates to construct bicyclo[3.1.0]hexane frameworks”, Angew. Chem. Int. Ed. 2021, 60, 13913.\r
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Ben-Xian Xiao, Bo Jiang, Ru-Jie Yan, Jian-Xiang Zhu, Ke Xie, Xin-Yue Gao, Qin Ouyang,* Wei Du,* and Ying-Chun Chen,* “A palladium complex as an asymmetric π-Lewis base catalyst for activating 1,3-dienes”, J. Am. Chem. Soc. 2021, 143, 4809.\r
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Bao-Xin Liu, Ru-Jie Yan, Xiao-Xun Li, Wei Du,* and Ying-Chun Chen,* “Asymmetric [3+2] annulations of thioaurone and aurone derivatives for the construction of spiroheterocycles”, Asian J. Org. Chem. 2021, 10, 784.\r
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Zhi-Chao Chen, Wei Du, and Ying-Chun Chen,* “New amines and activation modes in asymmetric aminocatalysis”, Chin. J. Chem. 2021, 39, 1775.\r
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Jian-Bin Lu, Chong-Hui Shi, Di Hu, Xin-Yue Gao, Zhi-Chao Chen,* Wei Du, and Ying-Chun Chen,* “Regioselectivity umpolung in asymmetric Diels-Alder reaction of ortho-formyl-substituted cinnamates and dienals via double aminocatalysis”, Org. Lett. 2021, 23, 145.\r
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Yang Gao, Xue Song, Ru-Jie Yan, Wei Du, and Ying-Chun Chen,* “Asymmetric β,γ¢-regioselective [4+3] and [4+2] annulations of a-vinylenals via cascade iminium ion−dienamine catalysis”, Org. Biomol. Chem. 2021, 19, 151.\r
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Cui-Xia Hu, Lin Chen, Di Hu, Xue Song, Zhi-Chao Chen,* Wei Du, and Ying-Chun Chen,* “Construction of enantioenriched 9H-fluorene frameworks via cascade reaction involving remote vinylogous dynamic kinetic resolution”, Org. Lett. 2020, 22, 8973.\r
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Xue Song, Ru-Jie Yan, Wei Du,* and Ying-Chun Chen,* “Asymmetric dearomative cascade multiple functionalizations of activated N-alkylpyridinium and N-alkylquinolinium salts”, Org. Lett. 2020, 22, 7617.\r
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Qing He, Zhen-Hong Yang, Jing Yang,* Wei Du, and Ying-Chun Chen,* “Enantioselective formal arylation of (7-aza)isatylidene malononitriles with a¢-alkylidene-2-cyclohexenones”, Adv. Synth. Catal. 2020, 362, 4438.