个人简历

教授/博士生导师,肿瘤生物研究室副主任,中国医药生物技术协会，纳米生物专业委员会理事；四川大学学报医学版编委， 英国 University of Wales Swansea 大学博士毕业，主要从事天然及小分子抗肿瘤、抗炎活性成分筛选、合成及相关新药研发；新型缓释药物载体材料的应用；液相色谱与质谱技术在药物代谢及药物动力学中的研究。近年来 已发表论文 115 篇， SCI 收录论文 95 篇，其中以第一作者 / 通讯作者在国际杂志上发表 SCI 收录论文 60 篇

研究领域

""天然药物活性成分的大规模分离纯化及结构修饰 •  新型缓释药物载体材料的研究   •  液相色谱与质谱技术在药物代谢及药物动力学中的研究    .  天然及小分子药物设计与开发。""""

近期论文

Liu X-Y, Yang J-L, Chen L-J* , Wei Y-Q*. A review of current applications of mass spectrometry for neuroproteomics in epilepsy: many technologies one goal. Mass Spec Rev. 2010 , 29:197-246. （ IF=11.507 ） \r
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Luo Y-F, Zheng H, Chen L-J* , Li R ， He C-M ， Yang S-Y ， Ye X, Chen Z-Z ， Li Z-C ， Gao Y ， Han J ， He G ， Yang L ， Wei Y-Q. Discovery of (Z)-5-(4-Methoxybenzylidene) thiazolidine -2, 4-dione ， a Readily Available and Orally Active Glitazone for the Treatment of Concanavalin A-induced Acute Liver Injury of BALB/c Mice. J Med Chem. 2010, 53(1) ， 273?C281. (IF=4.898) \r
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Hu J, Ye H-Y, Fu A-F, Chen X, Wang Y-S, Chen X-C, Ye X, Xiao W-J, Duan X-M, Wei Y-Q , Chen L-J*. . Deguelin-an inhibitor to tumor lymphangiogenesis and lymphatic metastasis by down-regulation of vascular endothelial cell growth factor-D in lung tumor model. Inter J Cancer. 2010,126(5),1282-1292 . （ IF=4.734 ） \r
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Wang X-H, Zhou J-C, Wang Y-S, Zhu Z-Y, Lu Y, Wei Y-Q, Chen L-J*. A phase I clinical and pharmacokinetic study of paclitaxel liposome infused in non-small-cell lung cancer patients with malignant pleural effusions. Eur J Cancer. 2010,46(2),449-455 . （ IF=4.475 ） \r
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Liang S-F, Fu A-F, Zhang Q, Tang M-H, Zhou J, Wei Y-Q, Chen L-J*. Honokiol inhibits HepG2 migration via downregulation of IQGAP1 expression discovered by a quantitative pharmaceutical proteomic analysis. Proteomics. 2010, 10(3) , 349-368 （ IF=4.586 ） \r
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Peng X-D, Wu X-H, Chen L-J *, Wang Z-L, Hu X-H, Song L-F, He C-M, Luo Y-F, Chen Z-Z, Jin K. Lin H-G, Li X-L, Wang Y-S, Wei Y-Q. Inhibition of Phosphoinositide 3-Kinase Ameliorates Dextran Sodium Sulfate-Induced Colitis in Mice. J Pharmacol Exp Ther. 2010,332 (1), 46-56. （ IF=4.309 ) \r
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Ye H-Y ， Zhong S-J ， Li Y-F ， Tang M-H ， Peng A-H ， Hu J ， Shi J ， He S-C ， Wu W-S ， Chen L-J *. Enrichment and isolation of barbigerone from Millettia pachycarpa Benth. using highspeed counter-current chromatography and preparative HPLC. J Sep Sci , 2010,33, 1?C8. (IF=2.746) \r
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Chen X, Wang X-H , Wang Y-S, Yang L * , Hu J, Xiao W-J, Fu A-F, Cai L-L, Li X, Ye X , Liu Y-L, Wu W-S, Shao X-M, Mao Y-Q, Wei Y-Q, Chen L-J * . Improved Tumor-Targeting Drug Delivery and Therapeutic Efficacy by Cationic Liposome Modified with Truncated bFGF Peptide. J Control Release, 2010, 145,17 ?C 25 (IF=5.69) \r
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Wang W-H, Fu A-F, Lan J-B, Gao Y, You J S *, Chen L-J*. Rational Design of Fluorescent Bioimaging Probes by Controlling Aggregation Behavior of Squaraines: A Special Effect of Ionic Liquid Pendants. CHEM-EUR J , 2010 , 16 , 5129 ?C 5137 (IF=5.454) \r
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Xiao W-J, Chen L-J* , Chen X, Yang L, Mao Y-Q, Zhao X, Wei Y-Q . . Co-delivery of Doxorubicin and plasmid by a novel FGFR-mediated cationic liposome. Int J Pharm ， 2010, 393, 119?C126 . (IF=3.061 ） \r
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Zhong Z-H , Wei X ， Qi B-W ， Xiao W-J, Fu A-F, Chen X, Hu J, Cai L-L, Yang L, Mao Y-Q, Wei Y-Q, Chen L-J * . A Fusion vaccine containing Liposomal bFGF and monophosphoryl lipid A, protect mice against tumor pulmonary metastasis. Int J Pharm ， 2010. doi:10.1016/j.ijpharm.2010.07.053 （ IF=3.061 ） \r
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Qi B-W ， Zhao Y-L ， Wei X ， Xiao W-J , Zheng H ， Chen Z-Z, Duan X-M, Lu Y ， Zhao X, Wei Y-Q, Chen L-J *. A further investigation concerning correlation between anti-fibrotic effect of liposomal quercetin and cytokines in pulmonary fibrosis. Eur J Pharmacol ， 2010, 10;642(1-3):134-9 . . （ IF=2.787 ） \r
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Shi J, Xu G-B, Chen L-J* , Peng A-H, Peng M, Luo Y-F, Ye H-Y, Zhong S-J, He S-C, Li S-C. Preparative purification of honokiol derivatives by high-speed counter-current chromatography. J Chromatogr A ， 2010, 1217,3461?C3465 （ IF=3.756 ） \r
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W ang X-H, Zheng H, Zhu Z-Y, Wei Y-Q, Ch en L-J *. Clinical pharmacokinetics of paclitaxel liposome with a new route of administration in human based on the analysis with ultra performance liquid chromatography. J Pharm Sci-US ， 2010. DOI: 10.1002/jps.22169 (I F=2.996) \r
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L uo H-D, Peng M, Ye H-Y, Chen L-J * , Peng A-H, Tang M-H, Zhang F, Shi J. Linear scale-up of four phenolic alkaloids separation from the roots of Menispermum dauricum using high-speed counter-current chromatography. J Chromatogr B ， 2010, . 878, 1929?C1933 （ IF=2.5 ） \r
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Peng A-H, Ye H-Y, Shi J, HeS-C ， Zhong S-J ， Chen L-J*. Parameters optimization in intermittent counter-current extraction (ICcE) and comparison of throughput between ICcE and common HSCCC. J Chromatogr A,2010, 1217, 5935?C5939 （ IF=3.756 ）