个人简历

2012年在巴斯大学（University of Bath）获得理学博士学位。2011年-2016年在剑桥大学（University of Cambridge）和桑格研究所(Wellcome Trust Sanger Institute)从事博士后研究工作 。2016年受聘于四川大学生物治疗国家重点实验室，任研究员。

研究领域

1，干细胞和癌症中选择性剪接调控 2，多组学在精准医学中的应用 3，疾病早期诊疗和药物靶点研究

近期论文

1) Chen L, Bing G, Casale F P et al. 2016. Genetic drivers of epigenetic and transcriptional variation in human immune cells. Cell 167, 1398–1414 2) Chen L, Kostadima M, Martens JH et al. 2014. Transcriptional diversity during lineage commitment of human blood progenitors. Science 345(6204): 1251033. (Highlighted in Nature Reviews Genetics). 3) Chen L, Bush SJ, Tovar-Corona JM et al. 2014. Correcting for Differential Transcript Coverage Reveals a Strong Relationship between Alternative Splicing and Organism Complexity. Molecular biology and evolution 31(6): 1402-1413. 4) Chen L, Tovar-Corona JM, Urrutia AO. 2012. Alternative splicing: a potential source of functional innovation in the eukaryotic genome. Int J Evol Biol 2012: 596274. (Review) 5) Chen L, Tovar-Corona JM, Urrutia AO. 2011. Increased levels of noisy splicing in cancers, but not for oncogene-derived transcripts. Human molecular genetics 20(22): 4422-4429 6) Chen L, Zhang QJ, Wang W, Wang YQ. 2010. Spatiotemporal expression of Pax genes in amphioxus: insights into Pax-related organogenesis and evolution. Sci China Life sci 53(8): 1031-1040. 7) Ecker S，Chen L, Pancaldi V et al. 2017. Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types. Genome Biol，18(1):18 8) Bush SJ，Chen L，Tovar-Corona JM，Urrutia AO，2017. Alternative splicing and the evolution of phenotypic novelty. Philos Trans R Soc Lond B Biol Sci 372, 1713 9) Astle WJ, Elding H, Jiang T et al. (including Chen L). 2016. Thousands of genetic variants modulate blood cell variation and function in humans. Cell 167, 1415-1429 10) The UK10K Consortium (including Chen L). 2015. The UK10K project: rare variants in health and disease. Nature 526 (7571): 82-90 11) Iotchkova V, Huang J, Morris JA et al. (including Chen L). 2016. Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps. Nature genetics doi:10.1038/ng.3668. 12) Shin SY, Fauman EB, Petersen AK (including Chen L) et al. 2014. An atlas of genetic influences on human blood metabolites. Nature genetics 46(6): 543-550. 13) Timpson NJ, Walter K, Min JL(including Chen L) et al. 2014. A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans. Nat. commun. 5: 4871. 14) Polfus L M, Khajuria R K, Schick U M et al. (including Chen L). Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants in Human Hematopoiesis. The American Journal of Human Genetics. 99(2), 481-488 15) Cheung A W, Shao X, Morin A et al. (including Chen L). 2017. Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome. Genome Biol，18(1):50 16) Vasquez L, Mann L A, Chen L, Soranzo N. 2015. From GWAS to function: lessons from blood cells. ISBT Science Series (0), 1–9 17) Tovar-Corona JM, Castillo-Morales A, Chen L et al. 2015. Alternative splice in alternative lice. Molecular biology and evolution, 32 (10), 2749-2759 18) Bush SJ, Castillo-Morales A, Tovar-Corona JM, Chen L et al. 2014. Presence-Absence Variation in A-thaliana Is Primarily Associated with Genomic Signatures Consistent with Relaxed Selective Constraints. Molecular biology and evolution 31(1): 59-69. 19) Wu XM, Tronholm A, Caceres EF（including Chen L) et al. 2013. Evidence for Deep Phylogenetic Conservation of Exonic Splice-Related Constraints: Splice-Related Skews at Exonic Ends in the Brown Alga Ectocarpus Are Common and Resemble Those Seen in Humans. Genome biology and evolution 5(9): 1731-1745.