个人简历

2013-至今四川大学 生物治疗国家重点实验室 副研究员 2006-2012 哈佛大学医学院 Dana-Farber癌症研究所 博士后 2001-2006 北京大学 生命科学学院 博士 1997-2001 北京大学 生命科学学院本科 2013年回国建立实验室以来，已在Nature, Science Advances, Nature Communications等杂志发表SCI论文15篇。受邀为Cell Research, BMC Genomics, Scientific Reports, Signal Transduct Target Ther.等杂志审稿。

研究领域

1、运用X-光晶体学以及其它实验方法研究生物大分子的结构与功能的关系，重点研究参与细胞信号转导的蛋白质分子，尤其是神经发育相关的细胞表面受体。一个长远目标是阐明生物信号跨膜传递的分子机制。 2、研究人类重大疾病的发病机制。基于结构的合理化药物设计，阐明药物的作用机制。

近期论文

1. Arnst KE, Wang Y, Hwang DJ, Xue Y, Costello T, Hamilton D, Chen Q, Yang J, Park F, Dalton JT, Miller DD, Li W. A Potent, Metabolically Stable Tubulin Inhibitor Targets the Colchicine Binding Site and Overcomes Taxane Resistance. Cancer Res. 2018 Jan 1;78(1):265-277. doi: 10.1158/0008-5472.CAN-17-0577. Epub 2017 Nov 27. 2. Cheng J, Wu Y, Wang Y, Wang C, Wang Y, Wu C, Zeng S, Yu Y#, Chen Q#. Structure of a benzylidene derivative of 9(10H)-anthracenone in complex with tubulin provides a rationale for drug design. Biochem Biophys Res Commun. 2018 Jan 1;495(1):185-188. doi: 10.1016/j.bbrc.2017.10.104. Epub 2017 Nov 2. 3. Liu S, Ji S, Yu ZJ, Wang HL, Cheng X, Li WJ, Jing L, Yu Y, Chen Q, Yang LL, Li GB, Wu Y. Structure-based discovery of new selective small molecule sirtuin 5 inhibitors. Chem Biol Drug Des. 2018;91:257–268. doi: 10.1111/cbdd.13077. 4. Wang K, Zhang T, Lei Y, Li X, Jiang J, Lan J, Liu Y, Chen H, Gao W, Xie N, Chen Q, Zhu X, Liu X, Xie K, Peng Y, Nice EC, Wu M, Huang C, Wei Y. Identification of ANXA2 (annexin A2) as a specific bleomycin target to induce pulmonary fibrosis by impeding TFEB-mediated autophagic flux. Autophagy. 2017 Nov 26:1-56. doi: 10.1080/15548627.2017.1409405. 5. Niu L, Wang Y, Wang C, Wang Y, Jiang X, Ma L, Wu C, Yu Y#, Chen Q#. Structure of 4′-demethylepipodophyllotoxin in complex with tubulin provides a rationale for drug design. Biochem Biophys Res Commun. 2017 Nov 4; 493(1):718-722. doi: 10.1016/j.bbrc.2017.08.125. Epub 2017 Aug 30. 6. Wang HL, Liu S, Yu ZJ, Wu C, Cheng L, Wang Y, Chen K, Zhou S, Chen Q, Yu Y, Li GB. Interactions between sirtuins and fluorogenic small-molecule substrates offer insights into inhibitor design. RSC Adv., 2017; 7: 36214–36222 7. Wang Y, Yu Y, Li GB, Li SA, Wu C, Gigant B, Qin W, Chen H, Wu Y, Chen Q#, Yang J#. Mechanism of microtubule stabilization by taccalonolide AJ. Nat Commun. 2017 Jun 6;8:15787. doi: 10.1038/ncomms15787. 8. Ji S, Ma S, Wang WJ, Huang SZ, Wang TQ, Xiang R, Hu YG, Chen Q, Li LL, Yang SY. Discovery of selective protein arginine methyltransferase 5 inhibitors and biological evaluations. Chem Biol Drug Des. 2017 Apr;89(4):585-598. doi: 10.1111/cbdd.12881. 9. Yang J, Wang Y, Wang T, Jiang J, Botting CH, Liu H, Chen Q, Yang J, Naismith JH, Zhu X, Chen L. Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule. Nat Commun. 2016 Jun 30;7:12103. doi: 10.1038/ncomms12103. 10. Li SA, Cheng L, Yu Y#, Chen Q#. Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition. Sci Adv. 2016 May 27; 2(5):e1501118. doi: 10.1126/sciadv.1501118. eCollection 2016 May. 11. Wang Y, Zhang H, Gigant B, Yu Y, Wu Y, Chen X, Lai Q, Yang Z, Chen Q#, Yang J#. Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery. FEBS J. 2016 Jan;283(1):102-11. doi: 10.1111/febs.13555. Epub 2015 Nov 4. 12. Wu CY, Liang MX, Chen Q#. Production and stabilization of an integrin-binding moiety of complement component 3. Mol Biol (Mosk). 2015 Sep-Oct;49(5):811-6. doi: 10.7868/S0026898415050201. 13. Cheng L, Li SA, Yu Y#, Chen Q#. Protein production, crystallization and preliminary crystallographic analysis of the four N-terminal immunoglobulin domains of Down syndrome cell adhesion molecule 1. Acta Crystallogr F Struct Biol Commun. 2015 Jun 1;71(Pt 6):775-8. 14. Li SA, Cheng L, Yu Y#, Chen Q#. Protein production, crystallization and preliminary X-ray analysis of two isoforms of the Dscam1 Ig7 domain. Acta Crystallogr F Struct Biol Commun. 2015 Mar 1;71(Pt 3):330-2. doi: 10.1107/S2053230X15002897. Epub 2015 Feb 19. 15. Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS#. CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature. 2015 Jan 15;517(7534):386-90. doi: 10.1038/nature13848. † 16. Schürpf T*, Chen Q*, Liu JH, Wang R, Springer TA, Wang JH#. The RGD finger of Del-1 is a unique structural feature critical for integrin binding. FASEB J. 2012; 26(8):3412-20. 17. Chen Q, Sun X, Zhou XH, Liu JH, Wu J, Zhang Y, Wang JH#. N-terminal horseshoe conformation of DCC is functionally required for axon guidance and may be shared by other neural receptors. J Cell Sci. 2013; 126(Pt 1):186-95. † 18. Chen Q, You D, Liang Y, Su X, Gu X, Luo M, Zheng X#. Crystal structure of Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyl transferase L160I mutant - insights into inhibitor design. FEBS J. 2007; 274(17): 4408-4415.