个人简历

1999年毕业于华西医科大学，获医学博士学位。2003年—2006年在日本名古屋大学医学部主要从事神经毒理学、神经药理学的研究工作。2006年9月回国，2006年12月被聘任为博士生导师，2007年5月评定为教授。迄今，在国内专业期刊发表文章20余篇，其中在SCI收录期刊发表多篇文章近20篇，包括Mol Psychiatry(IF 12)、J Neurosci(IF 8)、J Neurochem等国际著名刊物。目前正负责国家自然科学基金2项，国家重大新药创制项目1项，省级课题2项，参加多研国家及省级课题.

研究领域

主要研究领域为神经药理学、毒理学；药物安全性研究

近期论文

Bu Q, Yan G, Deng P, Peng F, Lin H, Xu Y, Cao Z, Zhou T, Xue A, Wang Y, Cen X, Zhao YL.? NMR-based metabonomic study of the sub-acute toxicity of titanium dioxide nanoparticles in rats after oral administration. Nanotechnology. 2010 Mar 26;21(12):125105. Epub 2010 Mar 5. Zhao Y, Bu Q, Zhou Y, Lv L, Yan G, Chen B, Wang L, Cen X. ?Mechanism study of Aconitum-induced neurotoxicity in PC12 cells: Involvement of dopamine release and oxidative damage. Neurotoxicology. 2010 Jun 30. [Epub ahead of print] Huang Y, Gao H, Gou M, Ye H, Liu Y, Gao Y, Peng F, Qian Z, Cen X, Zhao Y. Acute toxicity and genotoxicity studies on poly-(varepsilon-caprolactone)-(ethylene glycol)-poly(varepsilon-caprolactone) nanomaterials. Mutat Res. 2010,696(2):101-106. Ibi D, Nitta A, Ishige K, Cen X, Ohtakara T, Nabeshima T, Ito Y. Piccolo knockdown-induced impairments of spatial learning and long-term potentiation in the hippocampal CA1 region. Neurochem Int. 2009 Sep 17. [Epub ahead of print] Lv L, Yan GY, Zhao YL, He XJ, Jiang X, Zhuo YQ, Wang YL, Wang L, Cen XB. Investigation of the dermal sensitizing potential of traditional medical extracts in local lymph node assay. ?Exp Biol Med. 2009 Mar;234(3):306-13. Niwa M, Nitta A, Cen X, Kitaichi K, Ozaki N, Yamada K, Nabeshima T. A novel molecule 'shati' increases dopamine uptake via the induction of tumor necrosis factor-α in pheochromocytoma-12 cells. ?J Neurochem. 2008,107(6):1697 - 1708 Cen X, Nitta A, Ibi D, Zhao Y, Niwa M, Taguchi K, Ito Y, Ito Y, Wang L, Nabeshima T.??? Identification of Piccolo as a regulator of behavioral plasticity and dopamine transporter internalization. Mol Psychiatry. 2008 Apr;13(4):349, 451-63 Cen X, Nitta A, Ohya S, Zhao Y, Ozawa N, Mouri A, Ibi D, Wang L, Suzuki M, Saito K, Ito Y, Kawagoe T, Noda Y, Ito Y, Furukawa S, Nabeshima T. An analog of a dipeptide-like structure of FK506 increases glial cell line-derived neurotrophic factor expression through cAMP response element-binding protein activated by heat shock protein 90/Akt signaling pathway. J Neurosci. 2006 Mar 22;26(12):3335-44