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包锐
2023-05-12 12:31
  • 包锐
  • 包锐 - 研究员 博导-四川大学-生物治疗国家重点实验室-个人资料

近期热点

资料介绍

个人简历


2009年在同济大学获得理学博士学位。2009年 - 2014年,在美国国立健康研究院,美国国立癌症研究所从事博士后研究工作。2014年受聘于四川大学生物治疗国家重点实验室,任研究员。

研究领域


(1) 病原菌致病因子的结构与功能 (2) 病原菌与宿主侵染机制 (3) 革兰氏阴性菌耐药机制 (4) 抗菌疫苗与新型抗菌药物的研发

近期论文


1. Bao, R.; Nair, M. K.; Tang, W. K.; Esser, L.; Sadhukhan, A.; Holland, R. L.; Xia, D.; Schifferli, D. M., Structural basis for the specific recognition of dual receptors by the homopolymeric pH 6 antigen (Psa) fimbriae of Yersinia pestis. Proc Natl Acad Sci U S A 2013, 110 (3), 1065-70. 2. Bao, R.; Fordyce, A.; Chen, Y. X.; McVeigh, A.; Savarino, S. J.; Xia, D., Structure of CfaA suggests a new family of chaperones essential for assembly of class 5 fimbriae. PLoS Pathog 2014, 10 (8), e1004316. 3. Bao, R.; Zhou, C. Z.; Jiang, C.; Lin, S. X.; Chi, C. W.; Chen, Y., The ternary structure of the double-headed arrowhead protease inhibitor API-A complexed with two trypsins reveals a novel reactive site conformation. J Biol Chem 2009, 284 (39), 26676-84. 4.Bao, R.; Liu Y.; Savarino SJ.; Xia, D. Off-pathway assembly of fimbria subunits is prevented by chaperone CfaA of CFA/I fimbriae from enterotoxigenic E.coli. Mol Microbiol 2016, 102(6), 978-991 5. Bao, R.; Zhang, Y.; Zhou, C. Z.; Chen, Y., Structural and mechanistic analyses of yeast mitochondrial thioredoxin Trx3 reveal putative function of its additional cysteine residues. Biochim Biophys Acta 2009, 1794 (4), 716-21. 6. Bao, R.; Zhang, Y.; Lou, X.; Zhou, C. Z.; Chen, Y., Structural and kinetic analysis of Saccharomyces cerevisiae thioredoxin Trx1: implications for the catalytic mechanism of GSSG reduced by the thioredoxin system. Biochim Biophys Acta 2009, 1794 (8), 1218-23.

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