个人简历

于2013年获得清华大学博士学位，至2016年在清华大学医学院从事博士后研究，目前任清华医学院助理研究员。

研究领域

闫利明博士长期开展冠状病毒感染和复制机制、病毒与宿主相互作用、以及相关的抗病毒药物研究工作，揭示冠状病毒病毒感染和复制的分子机制，研究宿主因子功能机制、宿主与病毒相互关系，发现抗病毒新机制和新手段，为冠状病毒防控和药物研发提供重要结构基础。""

近期论文

L. Yan # , Y. Yang # , M. Li # , Y. Zhang # , L. Zheng # , J. Ge # , Y.C. Huang # , Z. Liu # , T. Wang, S. Gao, R. Zhang, Y.Y. Huang, L.W. Guddat, Y. Gao*, Z. Rao*, Z. Lou*, Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading, Cell, (2021).\r
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L. Yan # , J. Ge # , L. Zheng # , Y. Zhang, Y. Gao, T. Wang, Y. Huang, Y. Yang, S. Gao, M. Li, Z. Liu, H. Wang, Y. Li, Y. Chen, L.W. Guddat, Q. Wang, Z. Rao*, Z. Lou*, Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis, Cell, 184 (2021) 184-193 e110.\r
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L. Yan # , Y. Zhang # , J. Ge, L. Zheng, Y. Gao, T. Wang, Z. Jia, H. Wang, Y. Huang, M. Li, Q. Wang, Z. Rao*, Z. Lou*, Architecture of a SARS-CoV-2 mini replication and transcription complex, Nat Commun, 11 (2020) 5874.\r
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L.M. Yan # , Y.B. Qi # , X.F. Huang # , C.T. Yu # , L. Lan, X.Y. Guo, Z.H. Rao, J.J. Hu*, Z.Y. Lou*, Structural basis for GTP hydrolysis and conformational change of MFN1 in mediating membrane fusion, Nature structural & molecular biology, 25 (2018) 233-+.\r
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L. Yan # , Y. Qi # , D. Ricketson # , L. Li, K. Subramanian, J. Zhao, C. Yu, L. Wu, R. Sarsam, M. Wong, Z. Lou, Z. Rao*, J. Nunnari*, J. Hu*, Structural analysis of a trimeric assembly of the mitochondrial dynamin-like GTPase Mgm1, Proceedings of the National Academy of Sciences of the United States of America, 117 (2020) 4061-4070.