个人简历

教育经历\r
1998年9月-2003年1月，博士，香港科技大学\r
1995年9月-1998年7月，硕士，南开大学\r
1991年9月-1995年7月，学士，湖北大学\r
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工作经历\r
2011年11月-今，副研究员，清华大学深圳国际研究生院/清华大学深圳研究生院；\r
2010年10月-2011年10月，讲师，清华大学，深圳研究生院；\r
2007年1月-2010年8月，CRUK fellow,英国Beatson癌症研究所；\r
2003年3月-2006年12月,Research fellow,香港科技大学；

研究领域

研究方向：细胞生物学，主要研究非编码核酸、细胞周期检验点调控及DNA损伤修复、细胞自噬与凋亡及其与人类疾病特别是癌症和神经退行性疾病的关系。\r
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目前的主要研究方向是：\r
（1）泛素/去泛素化修饰与肿瘤发生发展和转移的研究；\r
（2）长链非编码核酸参与的表观遗传调控与癌症的关系；\r
（3）靶向自噬和DNA损伤修复通路的天然小分子和多肽药物研究。""

近期论文

Qin X, Wang R, Xu H, Tu L, Chen H, Li H, Liu N, Wang J, Li S, Yin F*, Xu N*, Li Z*.Identification of an autoinhibitory, mitophagy-inducing peptide derived from the transmembrane domain of USP30.Autophagy. 2022 Jan 6:1-20.\r
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Liao W, Xu N, Zhang H, Liao W, Wang Y, Wang S, Zhang S, Jiang Y, Xie W*, Zhang Y*.Persistent high glucose induced EPB41L4A-AS1 inhibits glucose uptake via GCN5 mediating crotonylation and acetylation of histones and non-histones. Clin Transl Med. 2022 Feb;12(2):e699.\r
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Cai J, Wang N, Lin G, Zhang H, Xie W, Zhang Y, Xu N*. MBNL2 regulates DNA damage response via stabilizing p21. Int J Mol Sci. 2021, 22(2),783.\r
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Liu G, Zhang Q, Xia L, Shi M, Cai J, Zhang H, Li J, Lin G, Xie W, Zhang Y, Xu N*. RNA-binding protein CELF6 is cell cycle regulated and controls cancer cell proliferation by stabilizing p21. Cell Death Dis. 2019 Sep 18; 10(10):688.\r
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Wang Z#, Zhao Y#, Xu N#, Zhang S, Wang S, Mao Y, Zhu Y, Li B, Jiang Y, Tan Y, Xie W, Yang BB*, Zhang Y*. NEAT1 regulates neuroglial cell mediating Ab clearance via the epigenetic regulation of endocytosis-related genes expression. Cell Mol Life Sci. 2019 Aug;76(15):3005-3018\r
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Liao M#, Liao W#, Xu N#, Li B, Liu F, Zhang S, Wang Y, Wang S, Zhu Y, Chen D, Xie W, Jiang Y, Cao L*, Yang BB*, Zhang Y*. LncRNA EPB41L4A-AS1 regulates glycolysis and glutaminolysis by mediating nucleolar translocation of HDAC2. EBioMedicine. 2019 Mar;41:200-213.\r
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Liu L#, He J#, Wei X, Lao Y, Xu W, Li Z, Hu H, Hu Z, Luo X, Wu J, Xie W, Zhang Y*, Xu N*. MicroRNA-20a-mediated loss of autophagy contributes to breast tumorigenesis by promoting genomic damage and instability. Oncogene. 2017 Jun 19. doi: 10.1038/onc.2017.193.\r
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Zhao H, Qin X, Yang D, Jiang Y, Zheng W, Wang D, Tian Y, Liu Q, Xu N*, Li Z*. The development of activatable lytic peptides for targeting triple negative breast cancer. Cell Death Discov. 2017 Jul 17:3:17037.\r
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Wu P, Xu N*, Tan C*, Liu L, Tan Y, Chen Z, Jiang Y. Light-Induced Translocation of a Conjugated Polyelectrolyte in Cells: From Fluorescent Probe to Anticancer Agent. ACS Appl Mater Interfaces. 2017 Mar 9;9(12):10512-10518.\r
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Wang Z, Fan P, Zhao Y, Zhang S, Lu J, Xie W, Jiang Y, Lei F, Xu N*, Zhang Y*. NEAT1 modulates herpes simplex virus-1 replication by regulating viral gene transcription. Cell Mol Life Sci.2017 Mar;74(6):1117-1131.\r
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Lao Y, Xu N*. Autophagy in Cancer Chemoprevention: Identification of Novel Autophagy Modulators with Anticancer Potential.Methods Mol Biol. 2016;1379:151-63.\r
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Tian Y, Li J, Zhao H, Zeng X, Wang D, Liu Q, Niu X, Huang X, Xu N*, Li Z*. Stapling of unprotected helical peptides via photoinduced intramolecular thiol–yne hydrothiolation. Chemical Sci. 2016 May 1;7(5):3325-3330.\r
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Liu EY, Xu N, O'Prey J, Lao LY, Joshi S, Long JS, O'Prey M, Croft DR, Beaumatin F, Baudot AD, Mrschtik M, Rosenfeldt M, Zhang Y, Gillespie DA, Ryan KM*. Loss of autophagy causes a synthetic lethal deficiency in DNA repair.Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):773-8.\r
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Wu J, Lv Q, He J, Zhang H, Mei X, Cui K, Huang N, Xie W, Xu N*, Zhang Y*. MicroRNA-188 suppresses G1/S transition by targeting multiple cyclin/CDK complexes.Cell Commun Signal. 2014 Oct 11;12:66.\r
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Lao Y, Wan G, Liu Z, Wang X, Ruan P, Xu W, Xu D, Xie W, Zhang Y, Xu H*, Xu N*. The natural compound oblongifolin C inhibits autophagic flux and enhances antitumor efficacy of nutrient deprivation.Autophagy. 2014 May;10(5):736-49.\r
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Wan G, Xie W, Liu Z, Xu W, Lao Y, Huang N, Cui K, Liao M, He J, Jiang Y, Yang BB, Xu H, Xu N*, Zhang Y*. Hypoxia-induced MIR155 is a potent autophagy inducer by targeting multiple players in the MTOR pathway.Autophagy. 2014 Jan;10(1):70-9.\r
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He J#, Wu J#, Xu N#, Xie W, Li M, Li J, Jiang Y, Yang BB*, Zhang Y*. MiR-210 disturbs mitotic progression through regulating a group of mitosis-related genes.Nucleic Acids Res. 2013 Jan 7;41(1):498-508.