个人简历

学习经历\r
1991年9月—1996年7月：清华大学生物科学与技术系获得学士学位\r
1996年9月—2001年7月：清华大学生物科学与技术系取得生化及分子生物学博士学位。\r
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工作经历\r
2001年8月—至今：清华大学生物科学与技术系讲师（2001）、副研究员（2006）、博士生导师（2010）、长聘副教授（2016）

研究领域

"""""1.合成生物学、组织工程及再生医学\r
2.以软骨再生与血管化为模型，利用单细胞测序等技术，进行组织再生修复评价、种子细胞作用机理、原位再生修复技术等方面的研究。\r
3. 血管再生中内皮细胞/干细胞间通讯及内皮细胞态间转变机制的研究；\r
4. 开发原核真核跨界合成生物学工具，进行工程化原核、真核细胞构建。\r
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希望利用单细胞、单分子检测等最新技术，深入了解软骨和血管组织再生等修复过程中因子调控网络、细胞间通讯机制和细胞态转换机制；并在此基础上，利用合成生物学手段对组织工程种子细胞进行可控理性化改造，并结合功能化生物材料支架进行组织工程修复及原位再生修复的探索。"

近期论文

Yu YT, Situ QJ, Jia WY, Li JX, Wu Q, Lei JZ. 2019. Data driven mathematical modeling reveals the dynamic mechanism of MSC-induced neovascularization. Faseb Journal 33: 3496-509\r
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Li JX, Luo HF, Wang R, Lang JD, Zhu SY, Zhang ZM, Fang JH, Qu KK, Lin YT, Long HZ, Yao Y, Tian G, Wu Q. 2016. Systematic Reconstruction of Molecular Cascades Regulating GP Development Using Single-Cell RNA-Seq. Cell Reports 15: 1467-80\r
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Yao Y, Jin SH, Long HZ, Yu YT, Zhang ZM, Cheng G, Xu CW, Ding Y, Guan Q, Li N, Fu SN, Chen XJ, Yan YB, Zhang HS, Tong P, Tan Y, Yu Y, Fu SS, Li J, He GJ, Wu Q. 2015. RNAe: an effective method for targeted protein translation enhancement by artificial non-coding RNA with SINEB2 repeat. Nucleic Acids Research 43\r
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Li JX, Ma Y, Teng RF, Guan Q, Lang JD, Fang JH, Long HZ, Tian G, Wu Q. 2015. Transcriptional Profiling Reveals Crosstalk Between Mesenchymal Stem Cells and Endothelial Cells Promoting Prevascularization by Reciprocal Mechanisms. Stem Cells and Development 24: 610-23\r
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Yao Y, He Y, Guan Q, Wu Q. 2014. A tetracycline expression system in combination with Sox9 for cartilage tissue engineering. Biomaterials 35: 1898-906\r
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Lin X, Wu L, Zhang ZM, Yang RH, Guan Q, Hou XF, Wu Q. 2014. MiR-335-5p Promotes Chondrogenesis in Mouse Mesenchymal Stem Cells and Is Regulated Through Two Positive Feedback Loops. Journal of Bone and Mineral Research 29: 1575-85\r
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Yan C, Wang Y, Shen XY, Yang G, Jian J, Wang HS, Chen GQ, Wu Q. 2011. MicroRNA regulation associated chondrogenesis of mouse MSCs grown on polyhydroxyalkanoates. Biomaterials 32: 6435-44\r
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Wang Y, Jiang XL, Yang SC, Lin X, He Y, Yan C, Wu L, Chen GQ, Wang ZY, Wu Q. 2011. MicroRNAs in the regulation of interfacial behaviors of MSCs cultured on microgrooved surface pattern. Biomaterials 32: 9207-17\r
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Bian YZ, Wang Y, Aibaidoula G, Chen GQ, Wu Q. 2009. Evaluation of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) conduits for peripheral nerve regeneration. Biomaterials 30: 217-25\r
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Wang Y, Bian Y-Z, Wu Q, Chen G-Q. 2008. Evaluation of three-dimensional scaffolds prepared from poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) for growth of allogeneic chondrocytes for cartilage repair in rabbits. Biomaterials 29: 2858-68