个人简历

教育经历\r
2008年09月-2013年01月，清华大学，博士\r
2005年09月-2008年07月，沈阳药科大学，硕士\r
2001年09月-2005年07月，齐齐哈尔大学，学士\r
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工作经历\r
2019年08月-至今，清华大学深圳国际研究生院，讲师\r
2018年03月-2019年08月，清华大学深圳研究生院，讲师\r
2015年07月-2018年02月，中国科学院大连化学物理研究所与南方科技大学联培，博士后\r
2013年03月-2015年08月，南方科技大学，Research Fellow（助理研究员）

研究领域

"主要研究方向：(1) 基于人工智能（AI）技术的多靶点抗肿瘤小分子化合物的设计、合成及其活性研究；(2) 手性药物导向的过渡金属/小分子协同催化的不对称合成。"

近期论文

Jin-Shun Lin #, Tao-Tao Li #, Guan-Yuan Jiao #, Qiang-Shuai Gu, Jiang-Tao Cheng, Ling Lv, and XinYuan Liu*. “Chiral Br?nsted Acid-Catalyzed Dynamic Kinetic Asymmetric Hydroamination of Racemic Allenes and Asymmetric Hydroamination of Dienes. Angew. Chem. Int. Ed.2019, 58, 7092. (#Co-first author) Highlighted in Synfacts2019, 15, 662.\r
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Jin-Shun Lin #, Tao-Tao Li #, Ji-Ren Liu #, Guan-Yuan Jiao, Qiang-Shuai Gu, Jiang-Tao Cheng, Yu-Long Guo, Xin Hong* and Xin-Yuan Liu*.“Cu/Chiral Phosphoric Acid-Catalyzed Asymmetric Three-Component Radical-Initiated 1,2-Dicarbofunctionalization of Alkenes’’. J. Am. Chem. Soc. 2019, 141, 1074. (#Co-first author) Highlighted in Synfacts2019, 15, 0255.\r
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Fu-Li Wang #, Xiao-Yang Dong #, Jin-Shun Lin#,Yang Zeng, Guang-Yuan Jiao, Qiang-Shuai Gu, Xiang-Qi Guo, Can-Liang Ma, Xin-Yuan Liu*.“Catalytic Asymmetric Radical Diamination of Alkenes. Chem 2017. 3, 979. (#Co-first author) Highlighted in Chem2017, 3, 919.\r
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Jin-Shun Lin #, Fu-Li Wang #, Xiao-Yang Dong #, Wei-Wei He, Yue Yuan, Su Chen, Xin-Yuan Liu*. “Catalytic Asymmetric Radical Aminoperfluoroalkylation and Aminodifluoromethylation of Alkenes with Fluoroalkylsulfonyl Chlorides: A Versatile Platform for Enantioenriched-Fluoroalkyl Amines”. Nat. Commun.2017,8, 14841. (#Co-first author).\r
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Jin-Shun Lin, Xiao-Yang Dong, Tao-Tao Li, Na-Chuan Jiang, Bin Tan, and Xin-Yuan Liu*. “A Dual-Catalytic Strategy to Direct Asymmetric Radical Aminotrifluoromethylation of Alkenes”. J. Am. Chem. Soc. 2016, 138, 9357. Highlighted in Synfacts, 2016, 12, 1020.Highlighted in Chin. J. Org. Chem.2016, 36, 2247.\r
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Jin-Shun Lin, Peng Yu, Lin Huang, Pan Zhang, Bin Tan,* and Xin-Yuan Liu*. “Br?nsted Acid-Catalyzed Asymmetric Hydroamination of Alkenes: Synthesis of Pyrrolidines Bearing a Tetrasubstituted Carbon Stereocenter”. Angew. Chem. Int. Ed.2015, 54, 7847. Highlighted in Chin. J. Org. Chem., 2015, 35, 1802.\r
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Lijuan Liu#, Zhichao Shi#, Xun Zhang, Feng Zhan, Jin-Shun Lin,* and Yuyang Jiang*. “Synthesis of α-Amino Tertiary Alkylperoxides by Lewis AcidCatalyzed Peroxidation of 1,3,5-Triazines”. Chem Asian J. 2021,16, 3487. (#Co-first author)\r
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Zhichao Shi#, Tingting Fan#, Xun Zhang Feng Zhan, Zhe Wang,Lei Zhao, Jin-Shun Lin* and Yuyang Jiang*. “Synthesis of Diversely Substituted Imidazolidines via [3+2] Cycloaddition of 1,3,5-Triazinanes with Donor-Acceptor Aziridines and Their Anti-Tumor Activity”. Adv. Synth. Catal. 2021,363, 2619. (#Co-first author)\r
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Zhe Wang #, Jiang-Tao Cheng #, Zhichao Shi, Na Wang, Feng Zhan, Sheng-Peng Jiang, Jin-Shun Lin,* Yuyang Jiang,* and Xin-Yuan Liu.* “Catalytic Asymmetric Intermolecular RadicalAminotrifluoromethylation of Alkenes with Hydrazines by Cu(I)/CPA Cooperative Catalysis”.ChemCatChem2021, 13, 185. (#Co-first author).\r
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Qinglu Zuo, Zhichao Shi, Feng Zhan, Zhe Wang, Jin-Shun Lin,*Yuyang Jiang,*“TfOH-catalyzed Formal [3+2] Cycloaddition of N-tosylaziridine Dicarboxylates and Nitriles: Synthesis of Tetrafunctionalized 2-Imidazolines”.Tetrahedron Lett.2020, 61, 151576.\r
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Yueying Zhang, Dan Gao,* Shangfu Li, Weili Wei, Jinshun Lin and Yuyang Jiang “1,5-Diaminonaphthalene functionalized carbon nanodots as a novel matrix for the analysis of small molecules by matrix-assisted laser desorption/ionization mass spectrometry”.Anal. Methods 2019, 11, 1131.\r
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Jin-Shun Lin, Ya-Ping Xiong, Can-Liang Ma, Li-Jiao Zhao, Bin Tan,* and Xin-Yuan Liu*. “Efficient Copper-Catalyzed Direct Intramolecular Aminotrifluoromethylation of Unactivated Alkenes with Diverse Nitrogen-Based Nucleophiles”. Chem. Eur. J.2014, 20, 1332.\r
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Jin-Shun Lin, Xiang-Geng Liu, Xiao-Long Zhu, Bin Tan,* and Xin-Yuan Liu*. “Copper-Catalyzed Aminotrifluoromethylation of Unactivated Alkenes with TMSCF3: Construction of Trifluoromethylated Azaheterocycles”. J. Org. Chem. 2014, 79, 7084.\r
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Peng Yu, Jin-Shun Lin, Lei Li, Sheng-Cai Zheng, Ya-Ping Xiong, Li-Jiao Zhao, Bin Tan*, and Xin-Yuan Liu*. “Enantioselective C-H Bond Functionalization Triggered by Radical Trifluoromethylation of Unactivated Alkene”.Angew. Chem. Int. Ed.2014, 53, 11890. Highlighted in Synfacts, 2014, 10, 1281.\r
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Zigao Yuan, Shaopeng Chen, Chunmei Gao, Qiuzi Dai, Cunlong Zhang, Qinsheng Sun, Jin-Shun Lin, Chun Guo, Yuzong Chen, Yuyang Jiang.* “Development of a versatile DNMT and HDAC inhibitor C02S modulating multiple cancer hallmarks for breast cancer therapy”. Bioorg Chem.2019, 87, 200.