个人简历

蒋宇扬博士1986年毕业于沈阳药科大学，1993年和1996年分别获得中国科学院应用生态研究所硕士和博士学位。1986-1990年任职于沈阳药科大学，1996-1998年，清华大学化学系博士后，师从赵玉芬院士。1998年10月-2004年11月，清华大学化学系副教授、清华大学生命有机磷化学与化学生物学教育部重点实验室常务副主任(2001年3月)；2004年11月-至今，清华大学化学系/医学院教授、清华大学深圳研究生院广东省化学生物学重点实验室主任，2010年7-至今，深圳市化学生物学重点实验室--省部共建国家重点实验室培育基地主任，从事肿瘤化学生物学研究工作。 在工作期间，蒋宇扬博士长期从事“一个基因(pokemon)两种疾病（肝癌和乳腺癌）”的肿瘤化学生物学研究，在以pokemon为中心的基因调控网络研究及多靶点抗肿瘤药物研发方面获得了一系列创新性成果，创建并形成了新的基于化学生物学的肿瘤个体化诊疗研究技术平台和理论体系。蒋宇扬博士已授权23项中国专利，发表~220余篇学术论文，并应邀在众多国内外会议，包括The 1st Shenzhen International Biotech Innovation Forum & Exhibition Invitation等会议上做学术报告。蒋宇扬博士是“Protein and Peptide Letters”，“Chinese Chemical Chemistry” 以及 “中国新药杂志”的编委。

研究领域

""蒋宇扬课题组的研究方向包括：1）肿瘤诊断检测；2）pokemon信号传导通路研究；3）多靶点高通量药物筛选技术研究及抗肿瘤药物研发；4）肿瘤的代谢组学和蛋白质组学研究；5）基于荧光共轭聚合物的生物分析、细胞成像及药物转运研究""""

近期论文

Zhang, W.; Zhang, B.; Zhang, W.; Yang, T.; Wang, N.; Gao, C.; Tan, C.; Liu, H.; Jiang, Y*., Synthesis and antiproliferative activity of 9-benzylamino-6-chloro-2-methoxy-acridine derivatives as potent DNA-binding ligands and topoisomerase II inhibitors. Eur. J. Med. Chem. 2016, 116, 59-70. \r
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Wang, Y.; Gao, D.; Chu, B.; Gao, C.; Cao, D.; Liu, H.; Jiang, Y*., Exposure of CCRF-CEM cells to acridone derivative 8a triggers tumor death via multiple mechanisms. Proteomics 2016, 16 (7), 1177-1190. \r
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Chen, Y.; Gao, D.; Liu, H.; Lin, S.; Jiang, Y*., Drug cytotoxicity and signaling pathway analysis with three-dimensional tumor spheroids in a microwell-based microfluidic chip for drug screening. Anal. Chim. Acta 2015, 898, 85-92. \r
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Mao, Y.; Liu, M.; Tram, K.; Gu, J.; Salena, B. J.; Jiang, Y*..; Li, Y., Optimal DNA Templates for Rolling Circle Amplification Revealed by In Vitro Selection. Chemistry-a European Journal 2015, 21 (22), 8069-8074. \r
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Tao, L.; Zhu, F.; Qin, C.; Zhang, C.; Chen, S.; Zhang, P.; Zhang, C.; Tan, C.; Gao, C.; Chen, Z.; Jiang, Y*.; Chen, Y. Z., Clustered Distribution of Natural Product Leads of Drugs in the Chemical Space as Influenced by the Privileged Target-Sites. Scientific Reports 2015, 5. \r
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Zhang, B.; Chen, K.; Wang, N.; Gao, C.; Sun, Q.; Li, L.; Chen, Y.; Tan, C.; Liu, H.; Jiang, Y*., Molecular design, synthesis and biological research of novel pyridyl acridones as potent DNA-binding and apoptosis-inducing agents. Eur. J. Med. Chem. 2015, 93, 214-226. \r
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Mao, Y.; Chen, Y.; Li, S.; Lin, S.; Jiang, Y*.., A Graphene-Based Biosensing Platform Based on Regulated Release of an Aptameric DNA Biosensor. Sensors (Basel, Switzerland) 2015, 15 (11), 28244-56. \r
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Gao, C.; Li, B.; Zhang, B.; Sun, Q.; Li, L.; Li, X.; Chen, C.; Tan, C.; Liu, H.; Jiang, Y*., Synthesis and biological evaluation of benzimidazole acridine derivatives as potential DNA-binding and apoptosis-inducing agents. Bioorg. Med. Chem. 2015, 23 (8), 1800-1807. \r
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Li, X.; Gao, C.; Yang, T.; Zhang, B.; Tan, C.; Liu, H.; Jiang, Y*., A POCl3-mediated synthesis of substituted fused azoacridones derivatives. Rsc Advances 2015, 5 (36), 28670-28678. \r
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He, S.; Qu, L.; Shen, Z.; Tan, Y.; Zeng, M.; Liu, F.; Jiang, Y*.; Li, Y., Highly Specific Recognition of Breast Tumors by an RNA-Cleaving Fluorogenic DNAzyme Probe. Analytical Chemistry 2015, 87 (1), 569-577. \r
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Chu, B.; Liu, F.; Li, L.; Ding, C.; Chen, K.; Sun, Q.; Shen, Z.; Tan, Y.; Tan, C.; Jiang, Y*., A benzimidazole derivative exhibiting antitumor activity blocks EGFR and HER2 activity and upregulates DR5 in breast cancer cells. Cell death & disease 2015, 6, e1686. \r
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Chen, K.; Chu, B.-z.; Liu, F.; Li, B.; Gao, C.-m.; Li, L.-l.; Sun, Q.-s.; Shen, Z.-f.; Jiang, Y*., New benzimidazole acridine derivative induces human colon cancer cell apoptosis in vitro via the ROS-JNK signaling pathway. Acta Pharmacologica Sinica 2015, 36 (9), 1074-1084. \r
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Gao, F.; Liu, F.; Zheng, J.; Zeng, M.; Jiang, Y*., A Catalytic DNA Probe with Stem-loop Motif for Human T47D Breast Cancer Cells. Analytical Sciences 2015, 31 (8), 815-822. \r
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Liu, H.; Li, X.; Liu, F.; Tan, Y.; Jiang, Y*., A simple and novel amide ligand based on quinoline derivative used for palladium-catalyzed Suzuki coupling reaction. Journal Of Organometallic Chemistry 2015, 794, 27-32. \r
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Tao, L.; Zhu, F.; Xu, F.; Chen, Z.; Jiang, Y*.; Chen, Y. Z., Co-targeting cancer drug escape pathways confers clinical advantage for multi-target anticancer drugs. Pharmacological Research 2015, 102, 123-131. \r
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Qin, C.; Tao, L.; Phang, Y. H.; Zhang, C.; Chen, S. Y.; Zhang, P.; Tan, Y.; Jiang, Y*.; Chen, Y. Z., The Assessment of the Readiness of Molecular Biomarker-Based Mobile Health Technologies for Healthcare Applications. Scientific Reports 2015, 5. \r
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Tao, L.; Zhu, F.; Qin, C.; Zhang, C.; Xu, F.; Tan, C. Y.; Jiang, Y*.; Chen, Y. Z., Nature's contribution to today's pharmacopeia. Nature biotechnology 2014, 32 (10), 979-80. \r
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Zhang, B.; Li, X.; Li, B.; Gao, C.; Jiang, Y*., Acridine and its derivatives: a patent review (2009-2013). Expert Opinion on Therapeutic Patents 2014, 24 (6), 647-664. \r
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Xin, T.; Zhang, C.; Tan, C.; Jiang, Y*., Biological Evaluation and Structure Modification of (S)-3-Aminopyrrolidine Derivatives. Chemical Research in Chinese Universities 2014, 30 (1), 91-97. \r
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Wu, Q.; Gao, D.; Wei, J.; Jin, F.; Xie, W.; Jiang, Y*.; Liu, H., Development of a novel multi-layer microfluidic device towards characterization of drug metabolism and cytotoxicity for drug screening. Chemical Communications 2014, 50 (21), 2762-2764. \r
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Li, B.; Gao, C.-M.; Sun, Q.-S.; Li, L.-L.; Tan, C.-Y.; Liu, H.-X.; Jiang, Y*., Novel synthetic acridine-based derivatives as topoisomerase I inhibitors. Chin. Chem. Lett. 2014, 25 (7), 1021-1024. \r
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Gao, D.; Jin, F.; Liu, H.; Wang, Y.; Jiang, Y*., Metabonomic study on the antitumor effect of flavonoid derivative 3d in HepG2 cells and its action mechanism. Talanta 2014, 118, 382-388. \r
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Chen, X.; Gao, D.; Liu, F.; Gao, X.; Wang, S.; Zhao, Y.; Liu, H.; Jiang, Y*., A novel quantification method for analysis of twenty natural amino acids in human serum based on N-phosphorylation labeling using reversed-phase liquid chromatography-tandem mass spectrometry. Anal. Chim. Acta 2014, 836, 61-71. \r
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Ding, C.; Zhang, C. L.; Zhang, M. L.; Chen, Y. Z.; Tan, C. Y.; Tan, Y.; Jiang, Y*., Multitarget inhibitors derived from crosstalk mechanism involving VEGFR2. Future Med Chem 2014, 6 (16), 1771-1789. \r
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Qu, L.; Ali, M. M.; Aguirre, S. D.; Liu, H.; Jiang, Y*.; Li, Y., Examination of Bacterial Inhibition Using a Catalytic DNA. PLoS One 2014, 9 (12). \r
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Chen, Z.; Liu, F.; Zhang, N.; Cao, D.; Liu, M.; Tan, Y.; Jiang, Y*., p38 beta, A Novel Regulatory Target of Pokemon in Hepatic Cells. Int. J. Mol. Sci. 2013, 14 (7), 13511-13524. \r
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Jin, F.; Gao, D.; Wu, Q.; Liu, F.; Chen, Y.; Tan, C.; Jiang, Y*., Exploration of N-(2-aminoethyl)piperidine-4-carboxamide as a potential scaffold for development of VEGFR-2, ERK-2 and Abl-1 multikinase inhibitor. Bioorg. Med. Chem. 2013, 21 (18), 5694-5706. \r
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Jin, F.; Gao, D.; Zhang, C.; Liu, F.; Chu, B.; Chen, Y.; Chen, Y. Z.; Tan, C.; Jiang, Y*., Exploration of 1-(3-chloro-4-(4-oxo-4H-chromen-2-yl)phenyl)-3-phenylurea derivatives as selective dual inhibitors of Raf1 and JNK1 kinases for anti-tumor treatment. Bioorg. Med. Chem. 2013, 21 (3), 824-831. \r
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Jin, X. L.; Sun, Q. S.; Liu, F.; Yang, H. W.; Liu, M.; Liu, H. X.; Xu, W.; Jiang, Y*., microRNA 21‐mediated suppression of Sprouty1 by Pokemon affects liver cancer cell growth and proliferation. Journal of Cellular Biochemistry 2013, 114, 1625-1633. \r
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Lang, X.; Li, L.; Chen, Y.; Sun, Q.; Wu, Q.; Liu, F.; Tan, C.; Liu, H.; Gao, C.; Jiang, Y*., Novel synthetic acridine derivatives as potent DNA-binding and apoptosis-inducing antitumor agents. Bioorg. Med. Chem. 2013, 21 (14), 4170-4177. \r
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Lang, X.-L.; Sun, Q.-S.; Chen, Y.-Z.; Li, L.-L.; Tan, C.-Y.; Liu, H.-X.; Gao, C.-M.; Jiang, Y*., Novel synthetic 9-benzyloxyacridine analogue as both tyrosine kinase and topoisomerase I inhibitor. Chin. Chem. Lett. 2013, 24 (8), 677-680. \r
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Liu, R.; Tan, Y.; Zhang, C.; Wu, J.; Mei, L.; Jiang, Y*.; Tan, C., A real-time fluorescence turn-on assay for trypsin based on a conjugated polyelectrolyte. Journal of Materials Chemistry B 2013, 1 (10), 1402-1405. \r
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Wu, J.; Tan, Y.; Xie, Y.; Wu, Y.; Zhao, R.; Jiang, Y*.; Tan, C., Diazobenzene-containing conjugated polymers as dark quenchers. Chemical Communications 2013, 49 (97), 11379-11381. \r
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Zhang, N.-N.; Sun, Q.-S.; Chen, Z.; Liu, F.; Jiang, Y*., Homeostatic regulatory role of Pokemon in NF-kappa B signaling: stimulating both p65 and I kappa B alpha expression in human hepatocellular carcinoma cells. Molecular and Cellular Biochemistry 2013, 372 (1-2), 57-64. \r
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Gao, D.; Liu, H.; Lin, J.-M.; Wang, Y.; Jiang, Y*., Characterization of drug permeability in Caco-2 monolayers by mass spectrometry on a membrane-based microfluidic device. Lab on a Chip 2013, 13 (5), 978-985. \r
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Wang, Y.; Gao, D.; Chen, Z.; Li, S.; Gao, C.; Cao, D.; Liu, F.; Liu, H.; Jiang, Y*., Acridone Derivative 8a Induces Oxidative Stress-Mediated Apoptosis in CCRF-CEM Leukemia Cells: Application of Metabolomics in Mechanistic Studies of Antitumor Agents. Plos One 2013, 8 (5), e63572. \r
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Gao, C. M.; Li, S. F.; Lang, X. L.; Liu, H. X.; Liu, F.; Tan, C. Y.; Jiang, Y*., Synthesis and evaluation of 10-(3,5-dimethoxy)benzyl-9(10H)-acridone derivatives as selective telomeric G-quadruplex DNA ligands. Tetrahedron 2012, 68 (38), 7920-7925. \r
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Gao, X.; Wu, H.; Lee, K.-C.; Liu, H.; Zhao, Y.; Cai, Z.; Jiang, Y*., Stable Isotope N-Phosphorylation Labeling for Peptide de Novo Sequencing and Protein Quantification Based on Organic Phosphorus Chemistry. Analytical chemistry 2012, 84 (23), 10236-10244. \r
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Han, B. C.; Ma, X. H.; Zhao, R. Y.; Zhang, J. X.; Wei, X. N.; Liu, X. H.; Liu, X.; Zhang, C. L.; Tan, C. Y.; Jiang, Y*.; Chen, Y. Z., Development and experimental test of support vector machines virtual screening method for searching Src inhibitors from large compound libraries. Chem Cent J 2012, 6. \r
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Jin, F.; Zhang, N.; Tan, C.; Gao, D.; Zhang, C.; Liu, F.; Chen, Z.; Gao, C.; Liu, H.; Li, S.; Jiang, Y*., 2'-Chloro-4'-aminoflavone Derivatives Selectively Targeting Hepatocarcinoma Cells: Convenient Synthetic Process, G2/M Cell Cycle Arrest and Apoptosis Triggers. Archiv Der Pharmazie 2012, 345 (7), 525-534. \r
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Jin, Y. B.; Luan, X. D.; Liu, H. X.; Gao, C. M.; Li, S. F.; Cao, D. L.; Li, X. Y.; Cai, Z. W.; Jiang, Y*., Pharmacokinetics and metabolite identification of a novel VEGFR-2 and Src dual inhibitor 6-chloro-2-methoxy-N-(2-methoxybenzyl) acridin-9-amine in rats by liquid chromatography tandem mass spectrometry. Talanta 2012, 89, 70-76. \r
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Zhu, F.; Ma, X. H.; Qin, C.; Tao, L.; Liu, X.; Shi, Z.; Zhang, C. L.; Tan, C. Y.; Chen, Y. Z.; Jiang, Y*., Drug Discovery Prospect from Untapped Species: Indications from Approved Natural Product Drugs. Plos One 2012, 7 (7). \r
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Zhao, R.; Xie, Y. H.; Tan, Y.; Tan, C. Y.; Jiang, Y*., Binding of a bcl-2 Family Inhibitor to Bovine Serum Albumin: Fluorescence Quenching and Molecular Docking Study. Protein and Peptide Letters 2012, 19 (9), 949-954. \r
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Zhang, X.; Tan, Y.; Zhao, R.; Chu, B.; Tan, C.; Jiang, Y*., Site-directed Mutagenesis Study of the Ile140 in Conserved Hydrophobic Core of Bcl-x(L). Protein and Peptide Letters 2012, 19 (9), 991-996. \r
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Zhang, J. X.; Han, B. C.; Wei, X. N.; Tan, C. Y.; Chen, Y. Z.; Jiang, Y*., A Two-Step Target Binding and Selectivity Support Vector Machines Approach for Virtual Screening of Dopamine Receptor Subtype-Selective Ligands. Plos One 2012, 7 (6). \r
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Zhang, J.; Jia, J.; Zhu, F.; Ma, X.; Han, B.; Wei, X.; Tan, C.; Jiang, Y*.; Chen, Y., Analysis of bypass signaling in EGFR pathway and profiling of bypass genes for predicting response to anticancer EGFR tyrosine kinase inhibitors. Molecular bioSystems 2012, 8 (10), 2645-56. \r
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Zhang, C. L.; Tan, C. Y.; Ding, H. W.; Xin, T.; Jiang, Y*., Selective VEGFR Inhibitors for Anticancer Therapeutics in Clinical Use and Clinical Trials. Current Pharmaceutical Design 2012, 18 (20), 2921-2935. \r
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Yang, X. F.; Zu, X. Y.; Tang, J.; Xiong, W.; Zhang, Y.; Liu, F.; Jiang, Y*., Zbtb7 suppresses the expression of CDK2 and E2F4 in liver cancer cells: Implications for the role of Zbtb7 in cell cycle regulation. Molecular Medicine Reports 2012, 5 (6), 1475-1480. \r
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Xie, Y. H.; Zhao, R.; Tan, Y.; Zhang, X.; Liu, F.; Jiang, Y*.; Tan, C. Y., Conjugated Polymer-Based Real-Time Fluorescence Caspase Assays. ACS Applied Materials & Interfaces 2012, 4 (1), 405-410. \r
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Xie, Y. H.; Tan, Y.; Liu, R. X.; Zhao, R.; Tan, C. Y.; Jiang, Y*., Continuous and Sensitive Acid Phosphatase Assay Based on a Conjugated Polyelectrolyte. ACS Applied Materials & Interfaces 2012, 4 (8), 3784-3787. \r
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Tian, J.; Jiang, Y*., Insulin upregulates the expression of zinc finger and BTB domain-containing 7A in HepG2 cells. Molecular Medicine Reports 2012, 6 (6), 1379-1384. \r
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Tan, Y.; Zhang, X.; Xie, Y. H.; Zhao, R.; Tan, C. Y.; Jiang, Y*., Label-free fluorescent assays based on aptamer-target recognition. Analyst 2012, 137 (10), 2309-2312. \r
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Liu, K.; Liu, F.; Zhang, N. N.; Liu, S. Y.; Jiang, Y*., Pokemon Silencing Leads to Bim-Mediated Anoikis of Human Hepatoma Cell QGY7703. Int. J. Mol. Sci. 2012, 13 (5), 5818-5831. \r
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Lin, J. S.; Liu, F.; Jiang, Y*., Antisense Technologies Targeting Fatty Acid Synthetic Enzymes. Recent Patents on Anti-Cancer Drug Discovery 2012, 7 (2), 198-206. \r
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Lin, J.; Jin, X.; Bu, Y.; Cao, D.; Zhang, N.; Li, S.; Sun, Q.; Tan, C.; Gao, C.; Jiang, Y*., Efficient synthesis of RITA and its analogues: derivation of analogues with improved antiproliferative activity via modulation of p53/miR-34a pathway. Organic & Biomolecular Chemistry 2012, 10 (48), 9734-9746. \r
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Lang, X. L.; Luan, X. D.; Gao, C. M.; Jiang, Y*., Recent Progress of Acridine Derivatives with Antitumor Activity. Progress in Chemistry 2012, 24 (8), 1497-1505. \r
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Zu, X.; Ma, J.; Liu, H.; Liu, F.; Tan, C.; Yu, L.; Wang, J.; Xie, Z.; Cao, D.; Jiang, Y*., Pro-oncogene Pokemon promotes breast cancer progression by upregulating survivin expression. Breast Cancer Res. 2011, 13, R26. \r
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Zhu, F.; Qin, C.; Tao, L.; Liu, X.; Shi, Z.; Ma, X.; Jia, J.; Tan, Y.; Cui, C.; Lin, J.; Tan, C.; Jiang, Y*.; Chen, Y., Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting. Proc. Natl. Acad. Sci. U. S. A. 2011, 108 (31), 12943-12948, S12943/1-S12943/139. \r
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Zhao, R.; Tan, C.; Xie, Y.; Gao, C.; Liu, H.; Jiang, Y*., One step synthesis of azo compounds from nitroaromatics and anilines. Tetrahedron Lett. 2011, 52 (29), 3805-3809. \r
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Zhang, Y.; Zu, X. Y.; Luo, W. S.; Tang, S. S.; Jiang, Y*., siRNA Induced CyclinB1 Knockdown Sensitizes HepG2 Cells to Daunorubicin. Prog. Biochem. Biophys. 2011, 38 (6), 551-557. \r
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Zhang, D.; Liu, H.; Zhang, S.; Chen, X.; Li, S.; Zhang, C.; Hu, X.; Bi, K.; Chen, X.; Jiang, Y*., An effective method for de novo peptide sequencing based on phosphorylation strategy and mass spectrometry. Talanta 2011, 84 (3), 614-622. \r
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Zhang, C.; Zhai, X.; Wan, F.; Gong, P.; Jiang, Y*., 2-Chloro-1- 4-(2-fluorobenzyl)piperazin-1-yl ethanone. Acta Crystallographica Section E-Structure Reports Online 2011, 67, O708-U2523. \r
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Zhang, C.; Tan, C.; Zu, X.; Zhai, X.; Liu, F.; Chu, B.; Ma, X.; Chen, Y.; Gong, P.; Jiang, Y*., Exploration of (S)-3-aminopyrrolidine as a potentially interesting scaffold for discovery of novel Abl and PI3K dual inhibitors. Eur. J. Med. Chem. 2011, 46 (4), 1404-1414. \r
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Luan, X.; Gao, C.; Zhang, N.; Chen, Y.; Sun, Q.; Tan, C.; Liu, H.; Jin, Y.; Jiang, Y*., Exploration of acridine scaffold as a potentially interesting scaffold for discovering novel multi-target VEGFR-2 and Src kinase inhibitors. Bioorg. Med. Chem. 2011, 19 (11), 3312-3319. \r
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Luan, X.; Gao, C.; Sun, Q.; Tan, C.; Liu, H.; Jin, Y.; Jiang, Y*., Novel synthetic azaacridine analogues as topoisomerase 1 inhibitors. Chem. Lett. 2011, 40 (7), 728-729. \r
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Li, Y.; Tan, C.; Gao, C.; Zhang, C.; Luan, X.; Chen, X.; Liu, H.; Chen, Y.; Jiang, Y*., Discovery of benzimidazole derivatives as novel multi-target EGFR, VEGFR-2 and PDGFR kinase inhibitors. Bioorg. Med. Chem. 2011, 19 (15), 4529-4535. \r
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Li, S.; Liu, H.; Jin, Y.; Lin, S.; Cai, Z.; Jiang, Y*., Metabolomics study of alcohol-induced liver injury and hepatocellular carcinoma xenografts in mice. J. Chromatogr., B: Anal. Technol. Biomed. Life Sci. 2011, 879 (24), 2369-2375. \r
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Hu, X.; Gao, C.; Tan, C.; Zhang, C.; Zhang, H.; Li, S.; Liu, H.; Jiang, Y*., Design and Synthesis of N-phosphoryl Peptide Modified Podophyllotoxin Derivatives as Potent Anticancer Agents. Protein and Peptide Letters 2011, 18 (12), 1258-1264. \r
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Chen, X. W.; Liu, H. X.; Jin, Y. B.; Li, S. F.; Bi, X.; Chung, S.; Zhang, S. S.; Jiang, Y*., Separation, identification and quantification of tetrodotoxin and its analogs by LC-MS without calibration of individual analogs. Toxicon 2011, 57 (6), 938-943.