个人简历

2010年获北京大学免疫学博士学位，2010-2015年在芝加哥大学从事博士后研究，2016年入选国家海外高层次人才青年项目。现任清华大学医学院、免疫学研究所研究员，博士生导师。

研究领域

郭教授长期从事肠道黏膜免疫与肠道菌群调控的研究，主要聚焦于富集于肠黏膜的3型天然淋巴样细胞ILC3的功能与机制研究，鉴定了多个调控ILC3发育和功能的重要因子，发现了ILC3在黏膜稳态以及多种疾病中的新作用及机制，阐明了肠道菌群及其代谢产物影响肠道感染、炎症以及抗肿瘤治疗疗效的作用机制。他的研究工作发表多篇高水平的科研论文，促进了肠道黏膜免疫领域的发展。""

近期论文

Liuhui Fu, Jie Zhao, Jiaoyan Huang, Na Li, Xin Dong, Yao He, Wenyan Wang, Yu Wang, Ju Qiu, Xiaohuan Guo*. A mitochondrial STAT3-methionine metabolism axis promotes ILC2-driven allergic lung inflammation. Journal of Allergy and Clinical Immunology. (2022) 149 (6): 2091-2104.\r
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Jiaoyan Huang, Liuhui Fu, Jida Huang, Jie Zhao, Xin Zhang, Wenyan Wang, Yeyang Liu, Bowen Sun, Ju Qiu, Xiaoyu Hu, Zhihua Liu, Xiaohuan Guo*. Group 3 innate lymphoid cells protect the host from the uropathogenic Escherichia coliinfection in the bladder. Advanced Science. (2022) 9: 2103303.\r
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Yao He, Liuhui Fu, Yiping Li, Wenyan Wang, Mingli Gong, Jing Zhang, Xin Dong, Jiaoyan Huang, Quanbo Wang, Charles R. Mackay, Yang-Xin Fu, Yun Chen, Xiaohuan Guo*. Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity. Cell Metabolism. (2021) 33(5): 988–1000.\r
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Wenyan Wang, Yan Xing, Yanmei Chang, Ying Wang, Yanxia You, Zekun Chen, Defu Ma*, Xiaomei Tong*, Xiaohuan Guo*. The Impaired Development of Innate Lymphoid Cells by Preterm Birth Is Associated with the Infant Disease. Science Bulletin. (2021) 66: 421-424.\r
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Wenyan Wang*, Yiping Li, Xiaohuan Guo*. A Mouse Model of Citrobacter rodentium Oral Infection and Evaluation of Innate and Adaptive Immune Responses. STAR Protocols. (2020) 1(3):100218.\r
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Wenyan Wang, Yiping Li, Jiacheng Hao, Yao He, Xin Dong, Yang-Xin Fu, Xiaohuan Guo*. The Interaction between Lymphoid Tissue Inducer-Like Cells and T Cells in the mLN Restrains Intestinal Humoral Immunity. Cell Reports. (2020)32(3): 107936.