个人简历

教育背景\r
清华大学自动化系 控制科学与工程，工学博士，2009年\r
清华大学自动化系 自动化，工学学士，2004年\r
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工作履历\r
2009年7月至2015年12月 清华大学 讲师\r
2016年1月至2017年11月 清华大学 助理教授、博导\r
2017年12月至今 清华大学 副教授、博导\r
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学术兼职\r
中国人工智能学会生物信息学与人工生命专委会常务委员\r
中国自动化学会青年工作委员会委员\r
中国生物工程学会计算生物学与生物信息学专委会委员\r
BMC Medical Genomics, Associate Editor

研究领域

"近年来致力于研究癌症组学大数据的智能信息处理，在癌症单细胞组学信息分析、组学数据低维特征学习、癌症耐药与预后预测模型构建等方面取得了若干成果。"

近期论文

Elucidating minimal residual disease of paediatric B-cell acute lymphoblastic leukaemia by single-cell analysis. Nature Cell Biology, 2022, 24(2):242-252. Yingchi Zhang#, Shicheng Wang#, Jingliao Zhang#, Chao Liu#, Xinqi Li#, Wenbo Guo, Yongjuan Duan, Xiaoyan Chen, Suyu Zong, Jiarui Zheng, Yixuan Wu, Xiaoli Chen, Xuelian Cheng, Yanxia Chang, Yue Wang, Feng Ding, Wenyu Yang, Xiaojuan Chen, Ye Guo, Li Zhang, Yumei Chen, Yao Zou, Xiaofan Zhu*, Jin Gu*, Tao Cheng*.\r
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Comprehensive analysis of spatial architecture in primary liver cancer. Science Advances 2021, 7:eabg3750. Rui Wu#, Wenbo Guo#, Xinyao Qiu#, Shicheng Wang, Chengjun Sui, Qiuyu Lian, Jianmin Wu, Yiran Shan, Zhao Yang, Shuai Yang, Tong Wu, Kaiting Wang, Yanjing Zhu, Shan Wang, Changyi Liu, Yangqianwen Zhang, Bo Zheng, Zhixuan Li, Yani Zhang, Siyun Shen, Yan Zhao, Wenwen Wang, Jinxia Bao, Ji Hu, Xuan Wu, Xiaoqing Jiang, Hongyang Wang*, Jin Gu*, Lei Chen*.\r
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Discovery of a Carbamoyl Phosphate Synthetase 1–Deficient HCC Subtype With Therapeutic Potential Through Integrative Genomic and Experimental Analysis. Hepatology 2021, 74(6):3249-3268. Tong Wu#, Guijuan Luo#, Qiuyu Lian#, Chengjun Sui#, Jing Tang#, Yanjing Zhu, Bo Zheng, Zhixuan Li, Yani Zhang, Yangqianwen Zhang, Jinxia Bao, Ji Hu, Siyun Shen, Zhao Yang, Jianmin Wu, Kaiting Wang, Yan Zhao, Shuai Yang, Shan Wang, Xinyao Qiu, Wenwen Wang, Xuan Wu, Hongyang Wang*, Jin Gu*, Lei Chen*.\r
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Integrative genomic analysis of gemcitabine resistance in pancreatic cancer by patient-derived xenograft models. Clinical Cancer Research 2021, 27:3383-3396. Gang Yang#, Wenfang Guan#, Zhe Cao#, Wenbo Guo#, Guangbing Xiong, Fangyu Zhao, Mengyu Feng, Jiangdong Qiu, Yueze Liu, Michael Q Zhang, Lei You*, Taiping Zhang*, Yupei Zhao*, Jin Gu*.\r
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scCancer: a package for automated processing of single cell RNA-seq data in cancer. Briefings in Bioinformatics 2021, 22(3):bbaa127. Wenbo Guo, Dongfang Wang, Shicheng Wang, Yiran Shan, Changyi Liu, Jin Gu*.\r
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Trajectory and functional analysis of PD-1high CD4+CD8+ T cells in hepatocellular carcinoma by single-cell cytometry and transcriptome sequencing. Advanced Science 2020, 7(13):2000224. Bo Zheng#, Dongfang Wang#, Xinyao Qiu#, Guijuan Luo#, Tong Wu, Shuai Yang, Zhixuan Li, Yanjing Zhu, Xuan Wu, Shan Wang, Ziqi Gu, Siyun Shen, Seogsong Jeong, Rui Wu, Yang Ge, Jin Gu*, Hongyang Wang*, Lei Chen*.\r
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VASC: dimension reduction and visualization of single cell RNA sequencing data by deep variational autoencoder. Genomics, Proteomics & Bioinformatics 2018, 16(5):320-331. Dongfang Wang, Jin Gu*.\r
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HCCDB: a database of hepatocellular carcinoma expression atlas. Genomics, Proteomics & Bioinformatics 2018, 16(4):269-275. Qiuyu Lian#, Shicheng Wang#, Guchao Zhang, Dongfang Wang, Guijuan Luo, Jing Tang, Lei Chen*, Jin Gu*.\r
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Genome-wide DNA methylation analysis identifies candidate epigenetic markers and drivers of hepatocellular carcinoma. Briefings in Bioinformatics 2018, 19(1):101-108. Yongchang Zheng#, Qianqian Huang#, Zijian Ding, Chenghai Xue, Tingting Liu, Xinting Sang, Jin Gu*.\r
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Network embedding based representation learning for single cell RNA-seq data. Nucleic Acids Research 2017, 45(19):e166. Xiangyu Li, Weizheng Chen, Yang Chen, Xuegong Zhang, Jin Gu*, Michael Q Zhang*.\r
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Evaluating the molecule-based prediction of clinical drug responses in cancer. Bioinformatics 2016, 32(19):2891-2895. Zijian Ding, Songpeng Zu, Jin Gu*.