个人简历

1985 武汉大学 学士 \r
1988 武汉大学 硕士 \r
1996 Pennsylvania State University 博士\r
University of Alberta 博士后\r
Oak Ridge National Laboratory 博士后\r
1/2000-12/2001 讲师，发育生物学系，爱因斯坦医学院\r
12/2001-7/2003 助理教授，医学系，爱因斯坦医学院\r
8/2003-12/2003 助理教授，内布拉斯加大学\r
1/2004-7/2009 研究助理教授，洛克菲勒大学\r
9/2009-2/2011 研究副教授和蛋白质组中心主任，洛克菲勒大学\r
9/2008-Present 客座研究员，纽约大学\r
3/2011-Present 客座教授，洛克菲勒大学\r
3/2011-Present 教授（2017年），清华大学

研究领域

"发展和应用蛋白质组学、代谢组学和化学生物学的技术和方法。研究氧化还原生物学在衰老和疾病中的功能和作用机制。发展衰老及其疾病相关的生物标志物。开发提高健康寿命的天然小分子、纳米抗体和疫苗。研究病原微生物-宿主细胞的相互作用。 鉴定肿瘤早期诊断的标记物并研究蛋白质药物的修饰和作用机制。"

近期论文

Wang W, Yang C, Wang T, Deng H., Complex roles of nicotinamide N-methyltransferase in cancer progression. Cell Death Dis. 2022 Mar 25;13(3):267.\r
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Yang C, Zhu S, Chen Y, Liu Z, Zhang W, Zhao C, Luo C, Deng H.，Flavonoid 4,4'-dimethoxychalcone suppresses cell proliferation via dehydrogenase inhibition and oxidative stress aggravation. Free Radic Biol Med. 2021 Nov 1; 175:206-215.\r
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Songbiao Zhu; Wenxi Ding; Yuling Chen; Weixuan Wang; Renhua Xu; Chongdong Liu; Xiaohui Liu; Haiteng Deng，High VHL Expression Reverses Warburg Phenotype and Enhances Immunogenicity in Kidney Tumour Cells，Genomics, Proteomics & Bioinformatics，2021 Feb 26:S1672-0229.\r
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Liu, Yan; Luo, Chengting; Li, Ting; Zhang, Wenhao; Zong, Zhaoyun; Liu, Xiaohui; Deng, Haiteng，Reduced Nicotinamide Mononucleotide (NMNH) Potently Enhances NAD+, Suppresses Glycolysis, TCA Cycle and Cell Growth，J Proteome Res. 2021 May 7;20(5):2596-2606.\r
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Liu J, Zong Z, Zhang W, Chen Y, Wang X, Shen J, Yang C, Liu X, Deng H., Nicotinamide Mononucleotide Alleviates LPS-Induced Inflammation and Oxidative Stress via Decreasing COX-2 Expression in Macrophages. Front Mol Biosci. 2021 Jul 6;8:702107.\r
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Jin J, Meng X, Huo Y, Deng H., Induced TRIM21 ISGylation by IFN-β enhances p62 ubiquitination to prevent its autophagosome targeting. Cell Death Dis. 2021 Jul 13;12(7):697.\r
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Zong Z, Liu J, Wang N, Yang C, Wang Q, Zhang W, Chen Y, Liu X, Deng H., Nicotinamide Mononucleotide Inhibits Hepatic Stellate Cell Activation to Prevent Liver Fibrosis via Promoting PGE2 Degradation., Free Radic Biol Med. 2021 Jan;162:571-581.\r
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Meiqi Yi, Yingying Ma, Yuling Chen, Chongdong Liu, Qingtao Wang, and Haiteng Deng. Glutathionylation decreases methyltransferase activity of PRMT5 and inhibits cell proliferation. Mol Cell Proteomics. 2020 Nov;19(11):1910-1920.\r
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Meiqi Yi, Yingying Ma, Songbiao Zhu, Chengting Luo, Yuling Chen, Qingtao Wang, Haiteng Deng. Comparative proteomic analysis identifies biomarkers for renal aging. Aging (Albany NY). 2020 Nov 6;12(21):21890-21903.\r
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Zhang, Lin; Shen, Hao; Gong, Yiyi; Pang, Xiaojing; Yi, Meiqi; Guo, Lin; Li, Jin; Arroyo, Sam; Lu, Xin; Ovchinnikov, Sergey; Cheng, Gong; Liu, Xudong; Jiang, Xu; Feng, Shan; Deng, Haiteng; Development of a dual-functional conjugate of antigenic peptide and Fc-III mimetics (DCAF) for targeted antibody blocking, Chemical Science, 2019, 10(11): 3271-3280.\r
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Teng, Ruifang; Liu, Zhilei; Tang, Haiping; Zhang, Wenhao; Chen, Yuling; Xu, Rrenhua; Chen, Liang; Song, Jiangping; Liu, Xiaohui; Deng, Haiteng; HSP60 silencing promotes Warburg-like phenotypes and switches the mitochondrial function from ATP production to biosynthesis in ccRCC cells, Redox Biology, 2019, 24: 101218.\r
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Chen P, Wang H, Zhang W, Chen Y, Lv Y, Wu D, Guo M Sr, Deng H.，Loss of BAP1 Results in Growth Inhibition and Enhances Mesenchymal-Epithelial Transition in Kidney Tumor Cells. Molecular Cell Proteomics. 2019 Jul;18(7):1320-1329.\r
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Wang, Weixuan; Hu, Yadong; Wang, Xiaofei; Wang, Qingtao; Deng, Haiteng*; ROS-mediated 15-Hydroxyprostaglandin Dehydrogenase Degradation via Cysteine Oxidation Promotes NAD+-Mediated Epithelial-Mesenchymal Transition, Cell Chemical Biology, 2018, 25: 1-7.\r
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Wang, Weixuan; Hu, Yadong; Yang, Changmei; Zhu, Songbiao; Wang, Xiaofei; Zhang, Zhenyu; Deng, Haiteng*; Decreased NAD Activates STAT3 and Integrin Pathways to Drive Epithelial-Mesenchymal Transition, Molecular Cell Proteomics, 2018, 17(10): 2005-2017.