个人简历

刘东，教授，博士生导师。于2011年获德国马克斯-德尔布吕克分子医学中心(Max-DelbrückCenterforMolecularMedicine)/柏林自由大学(FreieUniversit？tBerlin)，自然科学博士学位。从2012年起先后任神经再生重点实验室讲师、副教授、教授。中国解剖学会再生医学专业委员会委员，中国生物物理学会听觉分会委员，青年委员会常务委员，江苏省发育与细胞学会理事，江苏省神经科学会理事，江苏省发育生物学会听觉科学专业委员会副主任委员，江苏省神经科学会青年委员会委员。主讲本科生《分子生物学》和研究生《高级分子生物学》等课程。
主持课题:
2019-2022:国家自然科学基金-面上项目：血管新生的遗传调控
2016-2019:国家自然科学基金-面上项目：血管新生的遗传调控
2013-2015:国家自然科学基金-青年项目：血管新生的遗传调控
2018-2021:江苏省自然科学基金-杰出青年基金项目
2012-2015:江苏省自然科学基金-青年基金项目
2017-2020:江苏省高校自然科学研究项目-重大项目：血管新生
2016-2019:江苏省“六大人才高峰”高层次人才培养对象：血管新生
2014-2016:江苏省“双创计划”博士计划，境外世界名校创新类计划
2012-2014:江苏省高校自然科学研究项目-面上项目

研究领域

1、生理和病理条件下血管新生的遗传调控
2、神经发育以及相关疾病的发病机制
3、基于血管内皮细胞、毛细胞和运动神经元行为的化合物筛选

近期论文

1.BaoL,YouB,ShiS,ShanY,ZhangQ,YueH,ZhangJ,ZhangW,ShiY,LiuY,WangX,LiuDandYouY.Metastasis-associatedmiR-23afromnasopharyngealcarcinoma-derivedexosomesmediatesangiogenesisbyrepressinganoveltargetgeneTSGA10.Oncogene.2018;37:2873–2889(通讯作者)
2.YanW,LiuW,QiJ,FangQ,FanZ,SunG,HanY,ZhangD,XuL,WangM,LiJ,ChenF,LiuD,ChaiRandWangH.AThree-DimensionalCultureSystemwithMatrigelPromotesPurifiedSpiralGanglionNeuronSurvivalandFunctionInVitro.Molecularneurobiology.2018;55:2070-2084.(通讯作者)
3.ShanY,YouB,ShiS,ShiW,ZhangZ,ZhangQ,GuM,ChenJ,BaoL,LiuDandYouY.Hypoxia-InducedMatrixMetalloproteinase-13ExpressioninExosomesfromNasopharyngealCarcinomaEnhancesMetastases.CellDeathDis.2018;9:382.(通讯作者)
4.ZhangJ,QiJ,WuS,PengL,ShiY,YangJ,YinZ,GaoY,WangC,GongJ,ZhangH,ZhangJ,LiuD.FattyAcidBindingProtein11aIsRequiredforBrainVesselIntegrityinZebrafish.Frontiersinphysiology2017;8:214.(通讯作者)
5.XieY,WangD,LanF,WeiG,NiT,ChaiR,LiuD,HuS,LiM,LiD,WangH,WangY.Anepisomalvector-basedCRISPR/Cas9systemforhighlyefficientgeneknockoutinhumanpluripotentstemcells.Scientificreports2017;7:2320.
6.WangF,LiuD,ZhangRR,YuLW,ZhaoJY,YangXY,JiangSS,MaD,QiaoB,ZhangF,JinL,GuiYH,WangHY.ATBX53'UTRvariantincreasestheriskofcongenitalheartdiseaseintheHanChinesepopulation.Celldiscovery2017;3:17026.(共同一作)
7.MuZ,ZhangS,HeC,HouH,LiuD,HuN,XuH.ExpressionofSoxCTranscriptionFactorsduringZebrafishRetinalandOpticNerveRegeneration.Neurosciencebulletin2017;33:53-61.
8.LvF,ZhuC,YanX,WangX,LiuD.Generationofamef2aa:EGFPtransgeniczebrafishlinethatexpressesEGFPinmusclecells.Fishphysiologyandbiochemistry2017;43:287-294.(通讯作者)
9.JinD,ZhuD,FangY,ChenY,YuG,PanW,LiuD,LiF,ZhongTP.Vegfasignalingregulatesdiverseartery/veinformationinvertebratevasculatures.Journalofgeneticsandgenomics2017.
10.HeZ,GuoL,ShuY,FangQ,ZhouH,LiuY,LiuD,LuL,ZhangX,DingX,LiuD,TangM,KongW,ShaS,LiH,GaoX,ChaiR.Autophagyprotectsauditoryhaircellsagainstneomycin-induceddamage.Autophagy2017:1-21.
11.HeY,LuX,QianF,LiuD,ChaiR,LiH.Insm1aIsRequiredforZebrafishPosteriorLateralLineDevelopment.Frontiersinmolecularneuroscience2017;10:241.
12.GongJ,WangX,ZhuC,DongX,ZhangQ,WangX,DuanX,QianF,ShiY,GaoY,ZhaoQ,ChaiR,LiuD.Insm1aRegulatesMotorNeuronDevelopmentinZebrafish.Frontiersinmolecularneuroscience2017;10:274.(通讯作者)
13.ZhangS,MuZ,HeC,ZhouM,LiuD,ZhaoXF,GoldmanD,XuH.AntiviralDrugGanciclovirIsaPotentInhibitoroftheProliferationofMullerGlia-DerivedProgenitorsDuringZebrafishRetinalRegeneration.Investigativeophthalmology&visualscience2016;57:1991-2000.
14.WangX,YuanW,WangX,QiJ,QinY,ShiY,ZhangJ,GongJ,DongZ,LiuX,SunC,ChaiR,LeNobleF,LiuD.Thesomite-secretedfactorMaegpromoteszebrafishembryonicangiogenesis.Oncotarget2016;7:77749-77763.(通讯作者)
15.WangX,LingCC,LiL,QinY,QiJ,LiuX,YouB,ShiY,ZhangJ,JiangQ,XuH,SunC,YouY,ChaiR,LiuD.MicroRNA-10a/10brepressesanoveltargetgenemib1toregulateangiogenesis.Cardiovascularresearch2016;110:140-150.(通讯作者)
16.ShiYW,YuanW,WangX,GongJ,ZhuSX,ChaiLL,QiJL,QinYY,GaoY,ZhouYL,FanXL,JiCY,WuJY,WangZW,LiuD.CombretastatinA-4efficientlyinhibitsangiogenesisandinducesneuronalapoptosisinzebrafish.Scientificreports2016;6:30189.(通讯作者)
17.QiJ,DongZ,ShiY,WangX,QinY,WangY,LiuD.NgAgo-basedfabp11ageneknockdowncauseseyedevelopmentaldefectsinzebrafish.Cellresearch2016;26:1349-1352.(通讯作者)
18.HeZ,ZhangS,SongQ,LiW,LiuD,LiH,TangM,ChaiR.Thestructuraldevelopmentofprimaryculturedhippocampalneuronsonagraphenesubstrate.ColloidsandsurfacesB,Biointerfaces2016;146:442-451.
19.WangX,WangX,YuanW,ChaiR,LiuD.Egfl6isinvolvedinzebrafishnotochorddevelopment.Fishphysiologyandbiochemistry2015;41:961-969.(通讯作者)
20.WangX,ChongM,WangX,WangH,ZhangJ,XuH,ZhangJ,LiuD.BlockthefunctionofnonmusclemyosinIIbyblebbistatininduceszebrafishembryocardiabifida.Invitrocellular&developmentalbiologyAnimal2015;51:211-217.(通讯作者)
21.XuM,LiuD,DongZ,WangX,WangX,LiuY,BaasPW,LiuM.Kinesin-12influencesaxonalgrowthduringzebrafishneuraldevelopment.Cytoskeleton2014;71:555-563.(通讯作者)
22.WangX,LiL,LiuD.Expressionanalysisofintegrinbeta1isoformsduringzebrafishembryonicdevelopment.Geneexpressionpatterns:GEP2014;16:86-92.(通讯作者)
23.SangQ,ZhangJ,FengR,WangX,LiQ,ZhaoX,XingQ,ChenW,DuJ,SunS,ChaiR,LiuD,JinL,HeL,LiH,WangL.Ildr1bisessentialforsemicircularcanaldevelopment,migrationoftheposteriorlaterallineprimordiumandhearingabilityinzebrafish:implicationsforaroleintherecessivehearingimpairmentDFNB42.Humanmoleculargenetics2014;23:6201-6211.
24.LiS,LiuQ,WangY,GuY,LiuD,WangC,DingG,ChenJ,LiuJ,GuX.Differentialgeneexpressionprofilingandbiologicalprocessanalysisinproximalnervesegmentsaftersciaticnervetransection.PLoSOne2013;8:e57000.
25.JiangQ,Lagos-QuintanaM,LiuD,ShiY,HelkerC,HerzogW,leNobleF.miR-30aregulatesendothelialtipcellformationandarteriolarbranching.Hypertension2013;62:592-598.(通讯作者)
26.HuangY,WangX,XuM,LiuM,LiuD.NonmusclemyosinII-B(myh10)expressionanalysisduringzebrafishembryonicdevelopment.Geneexpressionpatterns:GEP2013;13:265-270.(通讯作者)
中文核心期刊：
27.高煜，刘家辉，王新，刘东，斑马鱼遗传操作进展，生物工程学报，2017,33(10):1674？1692(通讯作者)
28.张晶晶，王新，刘东，C型利钠肽基因调控斑马鱼胚胎血管发育，生理学报，2017,69(1):11–16(通讯作者)
29.吕峰，石运伟，王新，刘东，严兴洪，microRNA-10a/b通过抑制Mib1调节斑马鱼神经元的发育，中国细胞生物学学报，2017,39(2):191–196(通讯作者)
30.王鸿奎，王学谦，王新，袁玮，刘东，非肌性肌球蛋白II-B调节斑马鱼咽弓的发育,解剖学报，2016,47(1):113-116(通讯作者)
31.袁玮，浦超，RupeshPuri，石运伟，王新，李石营，刘东，Non-muscleMyosinII-A调节斑马鱼胚胎发育过程中肠内分泌细胞的极化，中国细胞生物学报，2015,37(3):328–334(通讯作者)
32.王新，张素珍，王学谦，李丽萍，张晶晶，刘东，流式细胞仪分选转基因斑马鱼胚胎荧光标记细胞的一种快速方法，中国细胞生物学报，2014,36(3):356–360(通讯作者)
2011年以前发表的论文：
1.LiuD,KruegerJ,LeNobleF.TheroleofbloodflowandmicroRNAsinbloodvesseldevelopment.IntJDevBiol2011;55:419-429.
2.KruegerJ,LiuD,ScholzK,ZimmerA,ShiY,KleinC,SiekmannA,Schulte-MerkerS,CudmoreM,AhmedA,leNobleF.Flt1actsasanegativeregulatoroftipcellformationandbranchingmorphogenesisinthezebrafishembryo.Development2011;138:2111-2120.
3.KleinC,MikuttaJ,KruegerJ,ScholzK,BrinkmannJ,LiuD,VeerkampJ,SiegelD,Abdelilah-SeyfriedS,leNobleF.Neuronnavigator3aregulatesliverorganogenesisduringzebrafishembryogenesis.Development2011;138:1935-1945.
4.JiangQ,LiuD,GongY,WangY,SunS,GuiY,SongH.yapisrequiredforthedevelopmentofbrain,eyes,andneuralcrestinzebrafish.BiochemBiophysResCommun2009;384:114-119.
5.LiuD,WangYX,HuJY,SunSN,SongHY.Theeffectsofconnexin43downregulationonthedevelopmentoftheembryonicheartandvasculatureinzebrafish.ProgressinBiochemistryandBiophysics2008;35:766-771.
6.WangYX,QianLX,LiuD,YaoLL,JiangQ,YuZ,GuiYH,ZhongTP,SongHY.Bonemorphogeneticprotein-2actsupstreamofmyocyte-specificenhancerfactor2atocontrolembryoniccardiaccontractility.Cardiovascularresearch2007;74:290-303.
7.SunSN,GuiYH,WangYX,QianLX,JiangQ,LiuD,SongHY.Effectofdihydrofolatereductasegeneknock-downontheexpressionofheartandneuralcrestderivativesexpressedtranscript2inzebrafishcardiacdevelopment.ChinMedJ(Engl)2007;120:1166-1171.