个人简历

Education
2004-2010，Department of Bioorganic Chemistry, Uppsala University, SWEDEN. Received PhD degree in April, 2010(with Prof. Jyoti Chattopadhyaya).
2001-2004，Institute of Elemento-Organic Chemistry, Nankai University, CHINA. Received MS degree in June, 2004 (with Prof. Zhen Xi).
1997-2001，Department of Chemistry, Nankai University, CHINA. Received BSc Degree in June, 2001.
Academic Career
2014-Date\tProfessor (tenure-track), State Key Laboratory of Elemento-organic Chemistry, Nankai University
2010-2014\tPostdoctoral Fellow，Johns Hopkins University. Advisor: Professor Marc M. Greenberg
Honors& Awards
2019 Young and Middle-aged Leading Personnel in Science and Technology Innovation of Tianjin City.
2009 Chinese Government Award for Outstanding Self-financed Students Studying Abroad.

研究领域

"""""(1) Chemical biology of biological macromolecules (nucleic acids and proteins).
(2) Medical chemistry."

近期论文

M. Ren, M. M. Greenberg*, C. Z. Zhou*, Participation of histones in DNA damage and repair within nucleosome core particles: Mechanism and applications. Acc. Chem. Res. 2022, DOI: 10.1021/acs.accounts.2c00041.
H. Wang, X. Shan, M. Ren, M. Shang, C. Z. Zhou*, Nucleosomes enter cells by clathrin- and caveolin-dependent endocytosis. Nucleic Acids Res. 2021, 49, 12306-12319.
M. Ren, M. Shang, H. Wang, Z. Xi, C. Z. Zhou*, Histones participate in base excision repair of 8-oxodGuo by transiently cross-linking with active repair intermediates in nucleosome core particles. Nucleic Acids Res. 2021, 49, 257-268.
H. Wang, C. Zang, M. Ren, M. Shang, Z. Wang, X. Peng, Q. Zhang, X. Wen, Z. Xi, C. Z. Zhou*, Cellular uptake of extracellular nucleosomes induces innate immune responses by binding and activating cGMP-AMP synthase (cGAS). Sci. Rep. 2020, 10, 15385.
Y. Zhang, C. Zang, G. An, M. Shang, Z. Cui, G. Chen, Z. Xi, C. Z. Zhou*, Cysteine-specific protein multi-functionalization and disulfide bridging using 3-bromo-5-methylene pyrrolones. Nat. Commun. 2020, 11, 1015.
Q. Li, J. Chen, M. Trajkovski, Y. Zhou, C. Fan, K. Lu, P. Tang, X. Su, J. Plavec, Z. Xi, C. Z. Zhou*， 4′-Fluorinated RNA: Synthesis, structure, and applications as a sensitive 19F NMR probe of RNA structure and function. J. Am. Chem. Soc. 2020, 142, 4739-4748.
C. Zang, H. Wang, T. Li, Y. Zhang, J. Li, M. Shang, J. Du, Z. Xi, C. Z. Zhou*, A light-responsive, self-immolative linker for controlled drug delivery via peptide- and protein-drug conjugates. Chem. Sci. 2019, 10, 8973-8980.
F. M. Guo, Z. K. Yue, M. Trajkovski, X. P. Zhou, D. Cao, Q. Li, B. F. Wang, X. Wen, J. Plavec*, Q. Peng*, Z. Xi, and C. Z. Zhou*, Effect of ribose conformation on RNA cleavage via internal transesterification. J. Am. Chem. Soc. 2018, 140, 11893-11897.
F. C. Li, Y. Q. Zhang, J. Bai, M. M. Greenberg, Z. Xi, C. Z. Zhou*, 5-Formylcytosine yields DNA-protein crosslinks in nucleosome core particles. J. Am. Chem. Soc. 2017, 139, 10617-10620. [Featured in JACS Spotlights: J. Am. Chem. Soc. 2017, 139, 11629].
Y. Q. Zhang, X. P. Zhou, Y. H. Xie, M. M. Greenberg, Z. Xi, and C. Z. Zhou*, Thiol specific and tracelessly removable bioconjugation via Michael addition to 5‑methylene pyrrolones. J. Am. Chem. Soc. 2017, 139, 6146−6151。