个人简历

学科方向\t 糖药物学和化学生物学
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1999年7月毕业于山东大学化学系，获学士学位；2005年4月毕业于中国科学院研究生院，获理学博士学位（师承孔繁祚研究员）。 2005年3月进入清华大学化学系从事博士后研究工作，师从李艳梅教授，从事糖肽的合成及免疫学性质研究。
2007年6月加入南开大学药学院。2009-2010年在美国俄亥俄州立大学化学与生物化学系作访问学者，并在美国国立卫生院（NIH）Frederick分部做短期交流访问。

研究领域

肿瘤相关糖疫苗、肝素类抗血栓药物的设计合成与生物学评价、基于结构和机制的小分子探针的合成""

近期论文

1.Yonghui Liu, Zhaoyu Wang, Fan Yu, Mingjing Li, Haomiao Zhu, Kun Wang, Meng Meng*, Wei Zhao*, “The Adjuvant of α-Galactosylceramide Presented by Gold Nanoparticles Enhances Antitumor Immune Responses of MUC1 Antigen-Based Tumor Vaccines ”, International Journal of Nanomedicine. 2021:16 403–420.
2.Shuo Wang, Zengyi Liu, Yue Tong, Yunqian Zhai, Xiujie Zhao, Xinmin Yue, Yanqi Qiao, Yonghui Liu, Yongmei Yin, Rimo Xi, Wei Zhao*, Meng Meng*, “ Improved cancer phototheranostic efficacy of hydrophobic IR780 via parenteral route by association with tetrahedral nanostructured DNA ”, Journal of Controlled Release. 2021, 330, 483-492.
3.Yonghui Liu, Bocheng Yan, Zhaoyu Wang, Haomiao Zhu, Xiaona Yin, Kun Wang, Menglei Wang, and Wei Zhao*,“Design, Synthesis, and Preliminary Immunological Studies of MUC1-Based Antitumor Vaccines Adjuvanted with R- and S‑FSL‑1”， ACS Med. Chem. Lett. 2020, 11, 7, 1371-1376.
4.Hongzhen Jin, Qiang Chen, Yan-Yan Zhang, Kai-Feng Hao, Guo-Qiang Zhang* and Wei Zhao*, “Preactivation-Based, Iterative One-Pot Synthesis of Anticoagulant Pentasaccharide Fondaparinux Sodium”， Organic Chemistry Frontiers, 2019, 6, 3116-3120.
5.Fan Yu, Song Guo, Te Li, Jie Ran, Wei Zhao, Dengwen Li, Min Liu, Xiumin Yan, Xiaoyong Yang, Xueliang Zhu, Jun Zhou*, “Ciliary defects caused by dysregulation of O-GlcNAc modification are associated with diabetic complications” , Cell Research, 2019, 209 (2), 171-173.
6.Mingjing Li, Fan Yu, Chao Yao, Peng George Wang, Yonghui Liu* and Wei Zhao*, “Synthetic and immunological studies on trimeric MUC1 immunodominant motif antigen-based anti-cancer vaccine candidates”, Organic & Biomolecular Chemistry, 2018, 16, 993-999.
7.Yonghui Liu, Youzhi Wang, Fan Yu, Zhenqing Zhang, Zhimou Yang, Wenpeng Zhang,* Peng George Wang and Wei Zhao *, “Potentiating the immune response of MUC1-based antitumor vaccines using a peptide-based nanovector as a promising vaccine adjuvant”. Chemical Communications, 2017, 53, 9486-9489.
8.Guoqiang Zhang, Hongzhen Jin, Yunyan Zhao, Lina Guo, Xue Gao, Xiaoxue Wang, Shiyang Tie, Jie Shen, Peng George Wang, Hao Gan, * Huifei Cui, * Wei Zhao*, An efficient anticoagulant candidate: Characterization, synthesis and in vivo study of a fondaparinux analogue Rrt1.17, European Journal of Medicinal Chemistry, 2017, 126, 1039-1055.
9.Yonghui Liu, Wenpeng Zhang, Qianqian He, Fan Yu, Tianbang Song, Tingting Liu, Zhenqing Zhang, Jun Zhou, Peng George Wang* and Wei Zhao*, “Fully synthetic self-adjuvanting MUC1-fibroblast stimulating lipopeptide 1 conjugates as potential cancer vaccines”. Chemical Communications, 2016, 52, 10886 - 10889.
10.Lina Guo, Taibao Liu, Kai Chen, Tianbang Song, Peng George Wang* and Wei Zhao*, “Facile synthesis of 5-hydroxy-L-lysine from D-galactose as a chiral-precursor”, Organic &_x005f_x000b_ Biomolecular Chemistry, 2014, 12, 7310–7317.
11.Lei Li, Yonghui Liu, Yue Wan, Yanhong Li, Xi Chen, Wei Zhao*, and Peng George Wang*,“Efficient Enzymatic Synthesis of Guanosine 5’-diphosphate-Sugars and Derivatives”. Organic letters. 2013, 21, 5528–5530.
12.Wenjun Wang,Chen Jin, Lina Guo, Yu Liu, Yue Wan, Xin Wang*, Lei Li*, Wei Zhao*, and Peng George Wang, “Preparation of oligosaccharides by homogenous enzymatic synthesis and solid phase extraction.” Chemical Communications, 2011, 47, 11240-11242.