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张博崴
2023-05-11 21:51
  • 张博崴
  • 张博崴 - 讲师-南开大学-医学院-个人资料

近期热点

资料介绍

个人简历


教育经历
2014.9-2018.7大连理工大学,生物化工专业,博士学位
2011.9-2014.7大连理工大学,生物化工专业,硕士学位
2007.9-2011.6辽宁大学,生物技术专业,学士学位

工作经历
2018.7-至今南开大学医学院,讲师

专利:
1.董悦生,张博崴,孙文龙,桑元斌,于晓霞,修志龙.一种具有α-糖苷酶抑制活性的药物组合物及其应用,专利号:ZL201510081001.8
2.董悦生,张博崴,文琛,孙文龙,余娜,修志龙.具有α-淀粉酶协同抑制活性的组合物,申请号:201710466865.0
3.董悦生,孙文龙,张博崴,桑元斌,于晓霞,徐亲民,修志龙.一种改善高脂高糖饮食并发症的药物组合物及其应用,专利号:ZL201510079721.0
4.董悦生,桑元斌,张博崴,徐亲民,修志龙.一种预防糖尿病药物组合物及其应用,专利号:ZL201210159072.1
5.董悦生,桑元斌,张博崴,徐亲民,修志龙.一种降糖药物组合物及其应用,中国发明专利,专利号:ZL201210158501.3
6.董悦生,孙文龙、张博崴、李夏、修志龙.预防或治疗前驱糖尿病的药物和药物组合物,中国发明专利,申请号:201710619663.5
7.董悦生,孙文龙、张博崴、李夏、修志龙.一种预防或治疗脂肪肝的药物及其应用,中国发明专利,申请号:201710625595.3

荣誉和奖励
2018年,辽宁省普通高等学校优秀毕业生
2017年,博士研究生国家奖学金

研究领域


1.天然药物和食品活性成分改善糖尿病的机制
2.膳食营养与肠道菌群的相互作用
2.黄酮的肠道代谢

近期论文


1.ZhangB,SunW,YuN,SunJ,YuX,LiX,XingY,YanD,DingQ,XiuZ,MaB,YuL,DongY*.Anti-DiabeticEffectofBaicaleinisAssociatedwiththeModulationofGutMicrobiotainStreptozotocinandHigh-Fat-DietInducedDiabeticRats.JournalofFunctionalFoods,2018,46:256-267.(I区TOP)
2.ZhangB,LiX,SunW,XingY,XiuZ,ZhuangC,DongY*.DietaryFlavonoidsandAcarboseSynergisticallyInhibitα-GlucosidaseandLowerPostprandialBloodGlucose.JournalofAgriculturalandFoodChemistry,2017,65:8319−8330.(I区TOP)
3.ZhangB,SangY,SunW,YuH,MaB,XiuZ,DongY*.CombinationofFlavonoidsfromOroxylumindicumSeedExtractsandAcarboseImprovestheInhibitionofPostprandialBloodGlucose:InVivoandInVitroStudy.Biomedicine&Pharmacotherapy,2017,91:890-898.
4.ZhangB,XingY,WenC,YuX,SunW,XiuZ,DongY*.PentacyclicTriterpenesasα-Glucosidaseandα-AmylaseInhibitors:Structure-activityRelationshipsandtheSynergismwithAcarbose.Bioorganic&MedicinalChemistryLetters,2017,27:5065-5070.
5.SunW,ZhangB,YuX,ZhuangC,LiX,SunJ,XingY,XiuZ,DongY*,OroxinAfromOroxylumindicumpreventstheprogressionfromprediabetestodiabetesinstreptozotocinandhigh-fat-dietinducedmice,Phytomedicine,2018,38:24-34.
6.SunW,ZhangB,ZhengH,ZhuangC,LiX,LuX,QuanC,DongY*,ZhengZ*,XiuZ,TrivaricAcid,aNewInhibitorofPTP1bwithPotentBeneficialEffectonDiabetes.LifeSciences,2016,169:52-64.
7.SunW,SunJ,ZhangB,XingY,YuX,LiX,XiuZ,DongY*,BaicaleinImprovesInsulinResistanceViaRegulatingSOCS3andEnhancestheEffectofAcarboseonDiabetesPrevention.JournalofFunctionalFoods,2017,37:339-353.
8.SunW,SangY,ZhangB,YuX,XuQ,XiuZ,YueshengDong*.SynergisticEffectsofAcarboseandanOroxylumindicumSeedExtractinStreptozotocinandHigh-Fat-DietInducedPrediabeticMice.Biomedicine&Pharmacotherapy,2017,87:160-70.
9.SunW,ZhuangC,LiX,ZhangB,LuX,ZhengZ,DongY*.VaricAcidAnaloguesfromFungusasPTP1BInhibitors:BiologicalEvaluationandStructure–activityRelationships.Bioorganic&MedicinalChemistryLetters,2017,27:3382–3385.

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