个人简历

学科方向\t 生物化学与分子生物学
2002-2006 中国农业大学农学与生物技术学院获学士学位
2007-2012 南开大学生命科学学院获博士学位
2012年7月-今南开大学药物化学生物学国家重点实验室，副研究员
2016年12月-2017年12月，加州大学洛杉矶分校，加州纳米系统研究所电镜中心，访问学者
2021年入选南开大学百青计划
本课题组的研究方向是跨膜信号传导相关重要蛋白的结构和功能研究，旨在利用冷冻电镜技术及X-射线晶体学方法解析目标蛋白的高分辨率三维结构，并结合生物化学、细胞生物学、荧光显微成像技术和电生理技术，深入研究细胞跨膜信号转导的分子机制，为相关疾病的治疗和药物的设计提供有效信息。

研究领域

钙离子的信号传导，结构生物学""

近期论文

1. Li L, Xing Y, Chang D, Fang S, Cui B, Li Q, Wang X, Guo S, Yang X*, Men S*, Shen Y*. CaM/BAG5/Hsc70 signaling complex dynamically regulates leaf senescence. Sci Rep. 2016 Aug 19;6:31889
2. Shao J, Fu Z, Ji Y, Guan X, Guo S, Ding Z, Yang X*, Cong Y*, Shen Y*. Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) forms a Ca2 /H antiporter. Sci Rep. 2016 Sep 27;6:34174.
3. Wang L, Yang X (co-first author), Li S, Wang Z, Liu Y, Feng J, Zhu Y, Shen Y* Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake. EMBO J. 2014 Mar 18;33(6):594-604.
4. Wang Z, Yang X (co-first author), Guo S, Yang Y, Su X, Shen Y*, Long J* Crystal structure of the ubiquitin-like domain-CUT repeat-like tandem of special AT-rich sequence binding protein 1 (SATB1) reveals a coordinating DNA-binding mechanism. J. Bio. Chem. 2014 Aug; 289(40).
5. Cui B, Yang X (co-first author), Li S, Lin Z, Wang Z, Dong C, Shen Y.* The inhibitory helix controls the intramolecular conformational switching of the C-terminus of STIM1. PLoS One. 2013 Sep 19;8(9)
6. Fang S, Li L, Cui B, Men S, Shen Y, Yang X.* Structural insi ht into plant programmed cell death mediated by BAG proteins in Arabidopsis thaliana. Acta Crystallogr. D Biol. Crystallogr. 2013 Jun;69(Pt 6):934-45
7. Dong C, Yang X (co-first author), Hou HF, Shen YQ*, Dong YH* Structure of Escherichia coli BamB and its interaction with POTRA domains of BamA. Acta Crystallogr D Biol Crystallogr. 2012 Sep;68(Pt 9)
8. Wang Z., Yang X (co-first author), Chu X., Zhang J., Zhou H., Shen Y.*, Long J.*. The structural basis for the oligomerization of the N-terminal domain of SATB1. Nucleic Acids Res. 2012 May; 40(9), 4193-202.
9. Yang X., Jin H., Cai X., Li S., Shen Y.* Structural and Mechanistic Insights into the Activation of STIM1, Proc. Nati. Acad. Sci. USA, 2012 April; 109(15), 5657–5662.
10. Li FZ., Li SW., Wang Z., Shen YQ, Zhang TC.*, Yang X.* Structure of the kinase domain of human RNA-dependent protein kinase with K296R mutation reveals a face-to-face dimer. Chinese Sci. Bull. 2013 Vol. 58 (9): 998-1002
11. Zhang J., Yang X., Wang Z., Shen Y.* Long J.* (2012) Structure of an L27 domain heterotrimer from the cell polarity complex Patj/Pals1/Mals2 reveals a mutually independent L27 domain assembly mode., J. Biol. Chem. 2012 Feb; 68 (Pt2): 95-101
12. Dong C., Hou H., Yang X., Shen Y., Dong Y.*. Structure of Escherichia coli BamD and its functional implications in outer membrane protein assembly. Acta Crystallogr. D Biol. Crystallogr. 2012 Feb;68 (Pt 2):95-101.
13. Zhang J., Yang X.*, Shen Y., Long J. Crystallization and preliminary X-ray data collection of the L27PATJ–(L27N,L27C)Pals1–L27MALS tripartite complex. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.2011 Nov 1;67(Pt 11):1443-7
14. Wang X., Yang X., Yang C., Wu Z., Xu H.*, Shen Y.* Crystal structure of outer membrane protein NMB0315 from Neisseria meningitidis. PLoS One. 2011 Oct;6(10): e26845.
15. Qin X., Ren L., Yang X., Bai F., Wang L., Geng P., Bai G.*, Shen Y.* Structures of human pancreatic α-amylase in complex with acarviostatins: Implications for drug design against type II diabetes.. J. Struct. Biol. 2011 Apr; 174(1): 196-202.
16. Yang X., Xie X., Chen L., Zhou H., Wang Z., Zhao W, Tian R, Zhang R, Tian C, Long J*, Shen Y*. Structural basis for tandem L27 domain-mediated polymerization. FASEB J. 2010 Dec; 24(12): 4806-15.
17. Qin X., Sun L., Wen X., Yang X., Tan Y., Jin H., Cao Q., Zhou W., Xi Z., Shen Y.*. Structural insight into unique properties of protoporphyrinogen oxidase from Bacillus subtilis. J. Struct. Biol. 2010 Apr; 170(1):76-82.
18. Yang, X., Wu, Z., Wang, X., Yang C., Xu, H.*, Shen, Y.* Crystal structure of lipoprotein GNA1946 from Neisseria meningitides. J.Struct.Biol., 2009 Dec; 168, 437-443.
19. Zhang J., Yan X., Shi C., Yang X., Guo Y., Tian C., Long J., Shen Y.* Structural basis of b-catenin recognition by Tax-interacting protein-1, J. Mol. Biol. 2008 Dec 5;384(1):255-63