杨卓
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个人简历
学科方向\t 药物设计的结构基础杨卓教授,南开大学医学院教授,博士生导师, 1983年毕业于天津医科大学临床医学专业, 获学士学位。1989年于浙江大学医学院,获医学硕士学位。1998年在英国伯明翰大学医学院,获生理学博士学位。2003回国受聘为南开大学医学院教授,创建神经生理实验室,从事生理学教学和科研工作。目前是中国生物物理学会理事会理事,天津神经科学学会理事,中华医学研究杂志专家编辑委员会常务编委,中华临床医学杂志英文版编委,天津医药杂志编委及英文编辑。每年招收1-2名硕士生及博士生。作为项目负责人目前主持2项国家自然科学基金面上项目、1项天津市自然科学基金重点项目。实验室的研究方向主要围绕神经系统重大疾病,通过相关的动物模型,进行行为学、神经电生理、免疫组化及神经元突触传递的机制研究,纳米材料在中枢神经系统的作用及其机制研究以及肾发育有关的离子通道机制研究。研究领域
神经生理学""近期论文
LiZhigui,HaoShuang,YinHongqiang,GaoJing,YangZhuo.AutophagyamelioratescognitiveimpairmentthroughactivationofPVT1andapoptosisindiabetesmice.BehaviouralBrainResearch.2016;305:265–277LuXiao,ChunhuaLiu,XiaoniaoChen,ZhuoYang.Zincoxidenanoparticlesinducerenaltoxicitythroughreactiveoxygenspecies.FoodandChemicalToxicology.2016;90:76–83WenLi,Yuen-KiCheong,HuiWang,GuogangRen,ZhuoYang.Neuroprotectiveeffectsofetidronateand2,3,3-trisphosphonateagainstglutamate-inducedtoxicityinPC12cells.NeurochemRes.2015;41:844-854JiajiaYang,ChunxiaoYang,ChunhuaLiu,TaoZhang,andZhuoYang,ParadoxicalEffectsofVEGFonSynapticActivityPartiallyInvolvedinNotch1SignalingintheMouseHippocampus.HIPPOCAMPUS26:589–600(2016)WeiMiaomiao,LiuChunhua,ZhangXiaochen,ChenXiaoniao,LinHongliandYangZhuo.AutophagyisinvolvedinregulatingVEGFduringhigh-glucose-inducedpodocyteinjury.Mol.BioSyst.,2016,12,2202—2212ChunhuaLiu,XiaxiaXu,JingGao,TaoZhang,ZhuoYang.HydrogensulfidepreventssynapticplasticityfromVD-induceddamageviaAkt/GSK-3βpathwayandNotchsignalingpathwayinrats.MolecularNeurobiology,2016;(53):4159–4172XiaochenZhang,WenLi,ZhuoYang.Toxicologyofnanosizedtitaniumdioxide:anupdate.ArchToxico,2015;Volume89(12):2207–2217ChunhuaLiu,HongqiangYin,JingGao,XiaxiaXu,TaoZhang,ZhuoYang.Leonurineamelioratescognitivedysfunctionviaantagonizingexcitotoxicglutamateinsultsandinhibitingautophagy.Phytomedicine,2016:1638-1646NaGao,HuiWang,XiaochenZhang&ZhuoYang.TheinhibitoryeffectofangiotensinIIonBKCachannelsinpodocytesviaoxidativestress.MolCellBiochem(2015)398:217–222XuanQin,YeLiu,MinghuiZhu,ZhuoYang,ThepossiblerelationshipbetweenexpressionsofTRPC3/5channelsandcognitivechangesinratmodelofchronicunpredictablestress.BehaviouralBrainResearch,2015;290:180–186ZhiguiLi,LifengWang,JingXu&ZhuoYang.MiRNAexpressionprofileandmiRNA–mRNAintegratedanalysis(MMIA)duringpodocytedifferentiation.MolecularGeneticsandGenomics.MolGenetGenomics,2015;290:863–875PengjuanXu,ZhiguiLi,QinjunXuan,ZhuoYang.Differentexpressionsoflarge-conductanceCa2+-activatedK+channelsinmouserenalcortexandhippocampusduringpostnataldevelopment.AppliedImmunohistochemistry&MolecularMorphology:2015;23(2):146-52YeLiu,ChunhuaLiu,XuanQin,MinghuiZhu,ZhuoYang.Thechangeofspatialcognitionabilityindepressionratmodelandthepossibleassociationwithdown-regulatedproteinexpressionofTRPC6.BehaviouralBrainResearch,2015;294:186–193JingGao,XiaochenZhang,MeiYu,GuogangRen,ZhuoYang.Cognitivedeficitsinducedbymulti-walledcarbonnanotubesviatheautophagicpathway.Toxicology337(2015):21–29XiaochenZhang,WenLi&ZhuoYang.Toxicologyofnanosizedtitaniumdioxide:anupdate.ArchivesofToxicology.2015;89:2207–2217MinghuiZhu,ChunhuaLiu,XuanQin,ZhuoYang.HyperforinalleviatesmooddeficitsofadultratssufferedfromearlyseparationNeuroscienceLetters.608(2015):1–5WeiMiaomiao,LiZhigui,XiaoLu,YangZhuo*.EffectsofROS-relativeNF-κBsignalingonhighglucose-inducedTLR4andMCP-1expressioninpodocyteinjury.MolecularImmunology,2015;68:261–271ZhaoweiLiu,JiajiaYang,XiaochenZhang,PengjuanXu,TaoZhang,ZhuoYang.DevelopmentalChangesintheExpressionandFunctionofTRPC6ChannelsRelatedtheF-actinOrganizationduringDifferentiationinPodocytes.CellCalcium,2015;58:541–548ChunhuaLiu,YeLiu,ZhuoYang.Myocardialinfarctioninducescognitiveimpairmentbyincreasingtheproductionofhydrogenperoxideinadultrathippocampus.NeuroscienceLetters.2014;(560):112-116LiuZhaowei,XieYongling,YangJiajia&YangZhuo.ThereductionofEPSCamplitudeinCA1pyramidalneuronsbytheperoxynitritedonorSIN-1requiresCa2+influxViapostsynapticnon-L-typevoltagegatedcalciumchannels.NeurochemRes.2014;39:361-371ZhangJunsi,LiYanna,XuJing,YangZhuo.TheroleofN-methyl-D-aspartatereceptorinAlzheimer'sdisease.JournaloftheNeurologicalSciences.2014;339:123-129XuLanju,XuJing,LiuShichang,YangZhuo,InductionofapoptosisbyantimycinAindifferentiatedPC12cellline.JournalofAppliedToxicology.2014;651–657MiaomiaoWei,ZhiguiLi,ZhuoYang.CrosstalkbetweenprotectiveautophagyandNF-κBsignalinhighglucose-inducedpodocytes.MolecularandCellularBiochemistry.2014;394(1-2):261-273WeiweiDai,JiajiaYang,TingChen,ZhuoYang.ProtectiveEffectsofBexaroteneagainstAβ25-35-InducedDysfunctioninHippocampalNeuronsthroughInsulinSignalingPathway.NeurodegenerativeDiseases.2014;14(2):77-84PengjuanXu,ZhiguiLi,XiaochenZhang,ZhuoYang.Increasedresponsetooxidativestresschallengeofnano-copper-inducedapoptosisinmesangialcells.JournalofNanoparticleResearch,2014;16(12):2777,1-13ZhiguiLi,JingXu,PengjuanXu,ShichangLiu,ZhuoYang.Wnt/β-cateninsignalingpathwaymediateshighglucoseinducedcellinjurythroughactivationofTRPC6inpodocytes.CellProlif.,2013,46,76–85标签: 南开大学 药物化学生物学国家重点实验室
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