个人简历

学科方向\t 生物抗体技术，免疫分析检测，食品残留检测
郗日沫教授，男，1995年获日本文部省冈崎国立共同研究机构分子科学研究所理学博士学位，1995年至1997年在美国芝加哥大学化学系从事博士后研究。1997年至1998年在美国威斯康星大学麦迪逊分校任博士后研究员。从1998-2003起，在美国生物技术公司从事生物技术免疫诊断试剂的研究，开发和市场化。2003年3月，成为山东大学化学与化工学院教授，组建了食品中药物残留免疫快速检测实验室，专门从事食品残留药物的免疫原的合成和相应免疫检测方法的研究。2009年1月，调到南开大学药学院担任药物分析教授，继续从事小分子化合物新型检测方法方面的研究。主要研究领域有：1）小分子抗原的合成和多克隆/单克隆抗体制备；2）生物免疫分析在血药浓度及儿童营养素方面的研究和应用；3）电化学免疫检测方法的研究与应用；4）新型非标记免疫检测方法的研发。

研究领域

""(1) The syntheses of antigens of small molecules and preparation of corresponding polyclonal and monoclonal antibodies.
(2) Purification and characterization of antibodies.
(3) Research and development of immunotechnical methods to detect drug residues .
(4) Development and application of novel immunoassay in bioanalysis and biomedical test.""""

近期论文

1. Xiujie Zhao, Hongjie Zhao, Shuo Wang, Zhiwen Fan, Yan Ma, Yongmei Yin, Wei Wang, Rimo Xi,* and Meng Meng*, A Tumor-Targeting Near-Infrared Heptamethine Cyanine Photosensitizer with Twisted Molecular Structure for Enhanced Imaging-Guided Cancer Phototherapy, J. Am. Chem. Soc. 2021, 143, 20828−20836.
2. Ying Zhang, Qian Liu, Mengting Liu, Xueni Zhang, Xiaoya Li, Lihui Dai, Meng Meng, Dingbin Liu, Yongmei Yin*, Rimo Xi*, Dual functional molecule aided background-free SERS sensor for intracellular pH dynamic monitoring based on foldable DNA transition, Sensors & Actuators: B. Chemical 353 (2022) 131162.
3. Qian Liu, Fang Wu, Huixia Di, Yingna Bi, Meng Meng, Dingbin Liu, Yongmei Yin*, Rimo Xi*, A novel SERS biosensor for ultrasensitive detection of mercury(II) in complex biological samples, Sensors & Actuators: B. Chemical 351 (2022) 130934.
4. Qian Liu, Xinmin Yue, Yixian Li, Fang Wu, Meng Meng, Yongmei Yin*, Rimo Xi*, A novel electrochemical aptasensor for exosomes determination and release based on specific host-guest interactions between cucurbit [7]uril and ferrocene, Talanta 232 (2021) 122451.
5. Xinmin Yue, Yanqi Qiao, Dening Gu, Rui Qi, Hongjie Zhao, Yongmei Yin, Wei Zhao, Rimo Xi* and Meng Meng*, DNA-Based pH Nanosensor with Adjustable FRET Responses to Track Lysosomes and pH Fluctuations, Anal. Chem. 2021, 93, 7250−7257.
6. Kai Wang, Ruixiao Zhang, Xinmin Yue, Zheng Zhou, Lihuan Bai, Yue Tong, Bei Wang, Dening Gu, Shuo Wang, Yanqi Qiao, Qian Liu, Xue Xue, Yongmei Yin, Rimo Xi*, Meng Meng*, Synthesis of Diboronic Acid-Based Fluorescent Probes for the Sensitive Detection of Glucose in Aqueous Media and Biological Matrices, ACS Sens. 2021, 6, 1543−1551.
7. Yanqi Qiao, Qingqing Xue, Xinmin Yue, Yang Liu, Qian Liu, Xiujie Zhao, Dening Gu, Shuo Wang, Kai Wang, Yongmei Yin, Jing Li, Rimo Xi*, Meng Meng*, A DNA nanoscaffold-based electrochemical assay for sensitive determination of O-GlcNAc transferase (OGT) activity and its application in cell-permeable OGT inhibitors screening, Sensors & Actuators: B. Chemical 334 (2021) 129665.
8. Xiujie Zhao, Zhiwen Fan, Yanqi Qiao, Yun Chen, Shuo Wang, Xinmin Yue, Tangliang Shen, Wenting Liu, Jie Yang, Heqi Gao, Xuelin Zhan, Luqing Shang, Yongmei Yin, Wei Zhao, Dan Ding, Rimo Xi*, Meng Meng*, AIEgens Conjugation Improves the Photothermal Efficacy and Near-Infrared Imaging of Heptamethine Cyanine IR-780, ACS Appl. Mater. Interfaces, 2020, 12: 16114–16124.
9. Xiujie Zhao, Yun Chen, Guiyu Niu, Dening Gu, Jianning Wang, Yanmei Cao, Yongmei Yin, Xiaogang Li, Dan Ding, Rimo Xi* and Meng Meng*, Photostable pH-Sensitive Near-Infrared Aggregation-Induced Emission Luminogen for Long-Term Mitochondrial Tracking, ACS Appl. Mater. Interfaces, 2019, 11: 13134–13139.
10. Xinmin Yue, Yanqi Qiao, Dening Gu, Zixuan Wu, Wenhui Zhao, Xiaoyu Li, Yongmei Yin, Wei Zhao, Deming Kong, Rimo Xi*, Meng Meng*, Reliable FRET-ON imaging of telomerase in living cells by a tetrahedral DNA nanoprobe integrated with structure-switchable molecular beacon, Sensors & Actuators: B. Chemical 2020, 312, 127943.
11. Li Xiaogang#, Liu Wei#, Yue Xinmin, Song Pei, Yin Yongmei, Meng Meng*, Xi Rimo*, A competitive immunoassay using hapten-modified polydiacetylene vesicles for homogeneous and sensitive detection of sodium benzoate, Sensors and Actuators B: Chemical, 2018, 258: 1060–1065.
12. Xiaogang Li, Meng Meng*, Lei Zheng, Zhihuan Xu, Pei Song, Yongmei Yin, Sergei A. Eremin and Rimo Xi*, Chemiluminescence Immunoassay for S-Adenosylhomocysteine Detection and Its Application in DNA Methyltransferase Activity Evaluation and Inhibitors Screening, Anal. Chem., 2016, 88 (17), pp 8556–8561.
13. Lisha Zhang, Pei Song, Hao Long, Meng Meng, Yongmei Yin*, Rimo Xi*, Magnetism based electrochemical immunosensor for chiral separation of amlodipine, Sensors and Actuators B: Chemical, 248 (2017) 682–689.
14. Kun Xu, Hao Long, Rongge Xing, Meng Meng*, Rimo Xi*, A sensitive chemiluminescent immunoassay to detect Chromotrope FB (Chr FB) in foods, Talanta, 2017, 164: 341–347.
15. L.S. Zhang, Z.R. Song, Y.Q. Dong, Y.F. Wang, X.G. Li, H. Long, K. Xu, C. Deng, M. Meng, Y.M. Yin*, R.M. Xi*, Enantiomeric separation of 1,4-dihydropyridines by liquid-phase microextraction with supercritical fluid chromatography, J. Supercrit. Fluids 107 (2016) 129-136.
16. Yaqing Dong, Jie Zhang, Yue Xing, Zhaorui Song, Yufen Wang, Meng Meng, Chuan Deng, Zhongsheng Tong, Yongmei Yin*, and Rimo Xi*, Quantification of Ponceau 4R in Foods by Indirect Competitive Enzyme-Linked Immunosorbent Assay (icELISA), J. Agric. Food Chem., 2015,63 (28): 6338-6345.
17. Lei Zheng#, Jing Wang#, Yufen Wang, Zhaorui Song, Yaqing Dong, Yongmei Yin & Sergei A. Eremin, Meng Meng*, Rimo Xi*, A sensitive chemiluminescent immunoassay for point-of-care testing of repaglinide in natural dietary supplements and serum, Anal. Bioanal. Chem., 2015, 407:1973–1980.
18. Linlin Ren, Meng Meng, Peng Wang, Zhihuan Xu, Sergei A. Eremin, Junhong Zhao, Yongmei Yin*, Rimo Xi*, Determination of sodium benzoate in food products by fluorescence polarization immunoassay. Talanta, 121 (2014) 136-143.
19. Yue Xing, Meng Meng, Huyin Xue, Taichang Zhang, Yongmei Yin*, Rimo Xi*. Development of a polyclonal antibody-based enzyme-linked immunosorbent assay (ELISA) for detection of Sunset Yellow FCF in food samples. Talanta, 2012, 99: 125–131.
20. Xiaoling Fu, Meng Meng*, Yu Zhang, Yongmei Yin, Xiangsheng Zhang*, Rimo Xi*, Chemiluminescence enzyme immunoassay using magnetic nanoparticles for detection of neuron specific enolase in human serum, Analytica Chimica Acta, 2012, 722: 114–118.