个人简历

简 介\t
2001.9-2004.7中国医学科学院/中国协和医科大学北京协和医院, 医学博士学位
1991.9-1998.7湖南医科大学临床医学系七年制, 医学硕士学位
2013.12- 南开大学医学院，教授
2008.06-2013.12 南开大学医学院，副教授
2004.08-2008.05 美国匹兹堡大学医学中心病理系 博士后
1998.08-2001.08 中南大学湘雅医学院附属第二医院 医师

研究领域

1． 纤维化相关肿瘤微环境维持肿瘤干细胞“niche”的机制
2. 上皮向间充质转分化在肿瘤转移及纤维化形成中的作用；
3． Vitamin D及其受体在治疗纤维化相关疾病中的作用及其机制。""

近期论文

1.ZhangY,ShenL,StupackDG,BaiN,XunJ,RenG,HanJ,LiL,LuoY,XiangR,TanX#.JMJD3promotessurvivalofdiffuselargeB-celllymphomasubtypesviadistinctmechanisms.Oncotarget.2016May17;7(20):29387-99.
2.ShenL,LiH,ShiY,WangD,GongJ,XunJ,ZhouS,XiangR,TanX#.M2tumour-associatedmacrophagescontributetotumourprogressionvialegumainremodellingtheextracellularmatrixindiffuselargeBcelllymphoma.SciRep.2016Jul28;6:30347.
3.ShenL,QinK,WangD,ZhangY,BaiN,YangS,LuoY,XiangR,TanX#.OverexpressionofOct4suppressesthemetastaticpotentialofbreastcancercellsviaRnd1downregulation.BiochimBiophysActa.2014Jul25.
4.LiuZ,XiongM,GongJ,ZhangY,BaiN,LuoY,LiL,WeiY,LiuY,TanX#,XiangR#.Legumainprotease-activatedTAT-liposomecargofortargetingtumoursandtheirmicroenvironment.NatCommun.2014Jun27;5:4280.
5.ZhangY,GuoQ,ZhangZ,BaiN,LiuZ,XiongM,WeiY,XiangR#,TanX#.VDRStatusArbitratesthePrometastaticEffectsofTumor-AssociatedMacrophages.MolCancerRes.2014Aug;12(8):1181-91.
6.BaiN,ZhangC,LiangN,ZhangZ,ChangA,YinJ,LiZ,LuoN,TanX,LuoN,LuoY,XiangR,LiX,ReisfeldRA,StupackD,LvD,LiuC.Yes-associatedprotein(YAP)increaseschemosensitivityofhepatocellularcarcinomacellsbymodulationofp53.CancerBiolTher.2013Jun;14(6):511-20.
7.LiuZ,LvD,LiuS,GongJ,WangD,XiongM,ChenX,XiangR,TanX#.Alginicacid-coatedchitosannanoparticlesloadedwithlegumainDNAvaccine:effectagainstbreastcancerinmice.PLoSOne.2013;8(4):e60190.doi:10.1371/journal.pone.0060190.
8.XiongM,GongJ,LiuY,XiangR,TanX#.LossofvitaminDreceptorinchronickidneydisease:apotentialmechanismlinkinginflammationtoepithelial-to-mesenchymaltransition.AmJPhysiolRenalPhysiol.2012Oct;303(7):F1107-15.
9.LuD,ChenS,TanX,LiN,LiuC,LiZ,LiuZ,StupackDG,ReisfeldRA,XiangR.Fra-1promotesbreastcancerchemosensitivitybydrivingcancerstemcellsfromdormancy.CancerRes.2012Jul15;72(14):3451-6.
10.ZhangM,LiuM,XiongM,GongJ,TanX#.Schisandrachinensisfruitextractattenuatesalbuminuriaandprotectspodocyteintegrityinamousemodelofstreptozotocin-induceddiabeticnephropathy.JEthnopharmacol.2012May7;141(1):111-8.
11.ZhangZ,YinJ,ZhangC,LiangN,BaiN,ChangA,LiuY,LiZ,TanX,LiN,LvD,XiangR,TianY,LiuC.Activatingtranscriptionfactor4increaseschemotherapeuticsresistanceofhumanhepatocellularcarcinoma.CancerBiolTher.2012Apr;13(6):435-42.
12.HuJ,QinK,ZhangY,GongJ,LiN,LvD,XiangR,TanX#.DownregulationoftranscriptionfactorOct4inducesanepithelial-to-mesenchymaltransitionviaenhancementofCa2+influxinbreastcancercells.BiochemBiophysResCommun.2011Aug12;411(4):786-91.
13.JiaX,LiX,XuY,ZhangS,MouW,LiuY,LiuY,LvD,LiuCH,TanX,XiangR,LiN.SOX2promotestumorigenesisandincreasestheanti-apoptoticpropertyofhumanprostatecancercell.JMolCellBiol.2011Aug;3(4):230-8.
14.TanX,HeW,LiuY.Combinationtherapywithparicalcitolandtrandolaprilreducesrenalfibrosisinobstructivenephropathy.KidneyInt.2009;76:1248-1257.(IF=6.193)
15.LiY,TanX,DaiC,StolzDB,WangD,LiuY.Inhibitionofintegrin-linkedkinaseattenuatesrenalinterstitialfibrosis.JAmSocNephrol.2009;20:1907-1918.(IF=7.689)
16.TanX,WenX,LiuY.ParicalcitolinhibitsrenalinflammationbypromotingvitaminDreceptor-mediatedsequestrationofNF-kappaBsignaling.JAmSocNephrol.2008;19:1741-1752.(IF=7.689)
17.GiannopoulouM*,DaiC*,TanX*,WenX,MichalopoulosGK,LiuY.Hepatocytegrowthfactorexertsitsanti-inflammatoryactionbydisruptingnuclearfactor-kappaBsignaling.AmJPathol.2008;173:30-41.(*:co-firstauthor)(IF=5.673)
18.HuK,LinL,TanX,YangJ,BuG,MarsWM,LiuY..tPAprotectsrenalinterstitialfibroblastsandmyofibroblastsfromapoptosis.JAmSocNephrol.2008;19:503-514.(IF=7.689)
19.TanX,LiYandLiuY.TherapeuticroleandpotentialmechanismsofactiveVitaminDinrenalinterstitialfibrosis.JSteroidBiochemMolBiol.2007:103:491-496.(IF=2.655)
20.TanX,LiY,LiuY.Paricalcitolattenuatesrenalinterstitialfibrosisinobstructivenephropathy.JAmSocNephrol.2006;17:3382-3393(IF=7.689)
21.TanX,ZhengFL,YangJH,DuanL,LiY,ZhouQG.EffectofBMP-7onthetransdifferentiationofculturedhumantubularepithelialcellinducedbyTGF-beta1.ACTAACADEMIAEMEDICINAESINICAE,2004;26:274-278.
22.TanX,ZhengFL,ZhouQG,DuanL,LiY.Effectofbonemorphogeneticprotein-7onmonocytechemoattractantprotein-1inducedepithelial-myofibroblasttransitionandTGF-beta1-Smad3signalingpathwayofHKCcells.NationalJournalofChina.2005;85:2607-2612.
23.GiannopoulouM,IszkulaSC,DaiC,TanX,YangJ,MichalopoulosGK,LiuY.DistinctiveroleofStat3andErk-1/2activationinmediatinginterferon-gammainhibitionofTGF-beta1action.AmJPhysiolRenalPhysiol.2006;290:F1234-1240.(IF=3.731)
24.TanR,ZhangJ,TanX,ZhangX,YangJ,LiuY.DownregulationofSnoNexpressioninobstructivenephropathyismediatedbyanenhancedubiquitin-dependentdegradation.JAmSocNephrol.2006;17:2781-2791.(IF=7.689)
25.ZhouQG,ZhengFL,WenYB,TanX,DuanL,LiY.Alteredexpressionofvascularendothelialgrowthfactoranditsreceptorsintransdifferentiatedhumanproximaltubularepithelialcellsinducedbytransforminggrowthfactorbeta1.ACTAACADEMIAEMEDICINAESINICAE.2005;27:325-331.