个人简历

Education \r
1998-2001 Department of Chemistry, Nankai University, China. Received PhD degree in June, 2001 (with Prof. Yun-Ti Chen) \r
1995-1998 Department of Chemistry, Nankai University, China. Received MS degree in June, 2001 (with Prof. Huakuan Lin)\r
1991-1995 Department of Chemistry, Qufu Normal University, Qufu, China. Received BSc Degree in June, 1991 \r
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Academic Career\r
2010- Professor, Institute of Elemento-organic Chemistry, College of Chemistry, Nankai University, Tianjin, China\r
2004-2010 Postdoctoral associate and then Research Fellow, Research School of Chemistry, Australian National University, Australia (with Prof. Gottfried Otting)\r
2001-2004 Postdoctoral associate, Magnetic Resonance Center (CERM), University of Florence, Italy (with Prof. Ivano Bertini)

研究领域

""Protein chemistry: methods in protein modifications, protein coupling reactions and biosynthesis\r
Methods of biological magnetic resonance for the in-cell applications\r
Chemical biology and biochemical analysis""""

近期论文

Su XC*, Zhang LY, Zhao LN, Pan BB, Chen BG, Chen JL, Zhai CL, Li B. Efficient protein-protein couplings mediated by small molecules under mild conditions. Angew. Chem. Int. Ed. Engl. 2022 doi: 10.1002/anie.202205597.\r
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Chen YT, Li B, Chen JL, Su XC*. Simultaneous discrimination and quantification of enantiomeric amino acids under physiological conditions by chiral 19F NMR tag. Anal. Chem. 2022, 94, 7853-7860.\r
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Wu X, Ma F*, Pan BB, Zhang Y, Zhu L, Deng F, Xu L, Zhao Y, Yin X, Niu H, Su XC*, Shi L*. Tailoring a nanochaperone to regulate α-synuclein assembly. Angew. Chem. Int. Ed. Engl. 2022 doi: 10.1002/anie.202200192.\r
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Cui CY, Li B, Cheng D, Li XY, Chen JL, Chen YT, Su XC*. Simultaneous quantification of biothiols and deciphering diverse GSH stability in different live cells by 19F-tag. Anal. Chem. 2022, 94, 901-908.\r
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Chen YT, Li B, Li XY, Chen JL, Cui CY, Hu K, Su XC*. Simultaneous identification and quantification of amino acids in biofluids by reactive 19F-tags. Chem. Commun. 2021, 13154-13157.\r
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Ma B, Chen JL, Cui CY, Yang F, Gong YJ, Su XC.* Rigid, highly reactive and stable DOTA-like tags containing a thiol-specific phenylsulfonyl pyridine moiety for protein modification and NMR analysis. Chem. Eur. J. 2021, 17, 16145-16152.\r
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Chen JL, Chen BG, Li B, Yang F, Su XC*. Assessing multiple conformations of lanthanide binding tags for proteins using a sensitive 19F‐reporter. Chem. Commun. 2021, 4291‐4294.\r
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Chen JL, Li B, Li XY, Su XC*. Dynamic exchange of the metal chelating moiety: a key factor in determining the rigidity of protein‐tag conjugates in paramagnetic NMR. J. Phys. Chem. Lett. 2020, 11, 9493‐9500.\r
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Yang Y, Chen SN, Yang F, Li XY, Feintuch A, Su XC*, Goldfarb* D. In‐cell destabilization of a homodimeric protein complex detected by DEER spectroscopy. Proc. Natl. Acad. Sci USA 2020, 117, 20566‐20575.\r
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Yang Y, Pan BB, Tan X, Yang F, Liu Y*, Su XC*, Goldfarb D*, In‐cell trityl‐trityl distance measurements on proteins. J. Phys. Chem. Lett. 2020, 11, 1141‐1147.\r
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Li M, Ning Y, Chen J, Duan X, Song N, Ding D*, Su X*, Yu Z*. Proline isomerization‐regulated tumor microenvironment‐adaptable self‐assembly of peptides for enhanced therapeutic efficacy. Nano. Lett. 2019, 19, 7965‐79768.\r
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Chen JL, Wang X, Xiao YH, Su XC*. Resonance assignments of lowly populated and unstable enzyme intermediate complex under real‐time conditions. Chembiochem. 2019, 20, 2738‐2742.\r
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Su XC*, Chen JL. Site‐specific tagging of proteins with paramagnetic ions for determination of protein structures in solution and in cells. Acc. Chem. Res. 2019, 52, 1675‐1686.\r
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Pan BB, Yang Y, Liu HZ, Li YH, Su XC*. Coordination of platinum to α‐synuclein inhibits filamentous aggregation in solution. Chembiochem. 2019, 20, 1953‐1958.\r
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Yang Y, Yang F, Li XY, Su XC*, Goldfarb D*. In‐cell EPR distance measurements on ubiquitin labeled with a rigid PyMTA‐Gd(III) tag. J. Phys. Chem B. 2019, 123, 1050‐1059.\r
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Wang X, Chen JL, Otting G, Su XC*. Conversion of an amide to a high‐energy thioester by Staphylococcus aureus sortase A is powered by variable binding affinity for calcium. Sci. Rep. 2018, 8:16371\r
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Yang Y, Yang F, Gong YJ, Bahrenberg T, Feintuch A, Su XC*, Goldfarb D*. High sensitivity in‐cell EPR distance measurements on proteins using an optimized Gd(III) spin label. J. Phys. Chem. Lett. 2018, 9, 6119‐6123\r
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Chen JL, Zhao Y, Gong YJ, Pan BB, Wang X, Su XC*. Stable and rigid DTPA‐like paramagnetic tags suitable for in vitro and in situ protein NMR analysis. J. Biomol. NMR 2018, 70, 77‐92.\r
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Li X, Wu G, Yang Y, Fu S, Liu X, Kang H, Yang X*, Su XC*, Shen Y*. Calmodulin dissociates the STIM1‐Orial complex and STIM1 oligomers. Nat. Commun. 2017, 8, 1042.\r
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Yang Y, Gong YJ, Litinov A, Liu HK, Yang F, Su XC*, Goldfarb D*. Generic Tags for Mn(II) and Gd(III) spin labels for distance measurements in proteins. Phys. Chem. Chem. Phys. 2017, 19, 26944‐26956.