个人简历

学科方向\t 药物分子合成与筛选
简 介\t
2004.09-2008.06 本科郑州大学化学基地班
2008.09-2013.06 博士南开大学化学院(导师：汪清民教授)
2013-2015 博士后 北京大学 化学院
2016-2020博士后 加州大学伯克利分校 化学系
2020.05- 教授 南开大学 药学院
研究主要集中在：以新药研发为导向、过渡金属催化为工具、解决有机合成(特别是药物合成)中的难题。尤其关注：1) 化学反应中的反应性和选择性；2) 药物研发中新结构和新先导合成；3) 具有重要生理活性分子的合成及生物活性研究。设计了一系列氮配体，首次实现了铱催化的不对称碳氢键硼化和硅化反应，并将其应用在药物和天然产物分子多样化合成。截至目前，以第一作者在Science，Acc. Chem. Res., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Org. Lett., J. Agric. Food. Chem.等发表论文近20余篇。

研究领域

1. 新配体的设计和新的化学反应的开发
2. 生物活性分子的合成和新药创制研究""

近期论文

1. R Oeschger,1 B Su,1 I Yu, C Ehinger, E Romero, S He, J Hartwig Diverse functionalization of strong alkyl C–H bonds by undirected borylation. Science 2020, 368, 736-741 (1Equal contribution)
2. B Su, A Bunescu, Y Qiu, SJ Zuend, M Ernst, JF Hartwig Palladium-Catalyzed Oxidation of β-C(sp3)–H Bonds of Primary Alkylamines through a Rare Four-Membered Palladacycle Intermediate. J. Am. Chem. Soc. 2020, 142, 7912-7919.
3. Y Xi,1 B Su,1 X Qi, S Pedram, P Liu, JF Hartwig Application of Trimethylgermanyl-Substituted Bisphosphine Ligands with Enhanced Dispersion Interactions to Copper-Catalyzed Hydroboration of Disubstituted Alkenes J. Am. Chem. Soc. 2020, 142, 18213-18222 (1Equal contribution)
4. Su, B.;1 Lee T.;1 Hartwig, J. F., Ir-Catalyzed Intramolecular Silylation of C-H Bonds of Aliphatic Amines. J. Am. Chem. Soc. 2018, 140, 18032. (1Equal contribution)
5. Su, B.; Hartwig, J. F., Ir-Catalyzed, Silyl-Directed, peri-Borylation of C-H Bonds in Fused Polycyclic Arenes and Heteroarenes Angew. Chem. Int. Ed. 2018, 57, 10163-10167.
6. Su, B.; Hartwig, J. F., Ir-Catalyzed Enantioselective, Intramolecular Silylation of Methyl C–H Bonds. J. Am. Chem. Soc. 2017, 139, 12137-12140.
7. Su, B.; Zhou, T.-G.; Xu, P.-L.; Shi, Z.-J.; Hartwig, J. F., Enantioselective Borylation of Aromatic C−H Bonds with Chiral Dinitrogen Ligands. Angew. Chem. Int. Ed. 2017, 56, 7205-7208.
8. Su, B.; Zhou, T.G.; Li, X.W.; Shao, X.R.; Xu, P.L.; Wu, W.L.; Hartwig, J. F.; Shi Z.-J., A Chiral Nitrogen Ligand for Enantioselective, Iridium-Catalyzed Silylation of Aromatic C-H Bonds. Angew. Chem. Int. Ed. 2017, 56, 1092-1096.
9. Su, B.; Cai, C.; Deng, M.; Wang, Q.-M., Spatial Configuration and Three-Dimensional Conformation Directed Design, Synthesis, Antiviral Activity, and Structure–Activity Relationships of Phenanthroindolizidine Analogues. J. Agric. Food. Chem. 2016, 64, 2039-2045.
10. Su, B.; Cao, Z.-C.; Shi, Z.-J., Exploration of Earth-Abundant Transition Metals (Fe, Co, and Ni) as Catalysts in Unreactive Chemical Bond Activations. Acc. Chem. Res. 2015, 48, 886-896.
11. Su, B.; Wei, J.B.; Wu, W.L.; Shi, Z.-J., Diversity-Oriented Synthesis through Rh-Catalyzed Selective Transformations of a Novel Multirole Directing Group. ChemCatChem 2015, 7, 2986-2990.
12. Su, B.; Zhang, H.; Deng, M.; Wang, Q.-M., An enantioselective strategy for the total synthesis of (S)-tylophorine via catalytic asymmetric allylation and a one-pot DMAP-promoted isocyanate formation/Lewis acid catalyzed cyclization sequence. Org. Biomol. Chem. 2014, 12, 3616-3621.
13. Su, B.;1 Deng, M.;1 Wang, Q.-M., Sodium Nitrite-Catalyzed Aerobic Oxidative Csp2-Csp3 Coupling: Direct Construction of the 4-Aryldihydroisoquinolinone Moiety. Adv. Synth. & Catal. 2014, 356, 977-981. (1Equal contribution)
14. Su, B.;1 Cai, C. L.;1 Deng, M.; Liang, D. M.; Wang, L. Z.; Wang, Q.-M, Design, synthesis, antiviral activity, and SARs of 13a-substituted phenanthroindolizidine alkaloid derivatives. Bioorg. Med. Chem. Lett. 2014, 24, 2881-2884. (1Equal contribution)
15. Su, B.;1 Chen, F.;1 Wang, L.; Wang, Q.-M., Design, Synthesis, Antiviral Activity, and Structure–Activity Relationships (SARs) of Two Types of Structurally Novel Phenanthroindo/quinolizidine Analogues. J. Agric. Food. Chem. 2014, 62, 1233-1239. (1Equal contribution)
16. Yang, M. Y.; Su, B.; Wang, Y.; Chen, K.; Jiang, X. Y.; Zhang, Y. F.; Zhang, X. S.; Chen, G. H.; Cheng, Y.; Cao, Z. C.; Guo, Q. Y.; Wang, L. S.; Shi, Z. -J., Silver-catalysed direct amination of unactivated C-H bonds of functionalized molecules. Nature Commun. 2014, 5. 4707-4712.
17. Su, B.;1 Deng, M.;1 Wang, Q.-M., Bioinspired Construction of a Spirocyclohexadienone Moiety via Sodium Nitrite Catalyzed Aerobic Intramolecular Oxidative Phenol Coupling. Org. Lett. 2013, 15, 1606–1609. (1Equal contribution)
18. Su, B.;1 Chen, F. Z.;1 Wang, Q.-M., A Novel Strategy for the Synthesis of Phenanthroindolizidine alkaloids via one-pot Intramolecular Schmidt/ Bischler-Napieralski/ Imine-reduction reaction. J. Org. Chem. 2013, 78, 2775–2779. (1Equal contribution)
19. Su, B.; Deng, M.; Wang, Q.-M., The first enantioselective approach to 13a-methyl-14-hydroxyphen- anthroindolizidine alkaloids: synthetic studies towards hypoestestatin 2. Eur. J. Org. Chem. 2013, 10, 1979–1985.
20. Su, B.; Cai, C. L.; Wang, Q.-M., Enantioselective Approach to 13a-Methylphenanthroindolizidine Alkaloids. J. Org. Chem. 2012, 77, 7981–7987.
21. Su, B.; Li, L.; Hu, Y. N.; Liu, Y. X.; Wang, Q.-M., A Novel Sodium Nitrite-Catalyzed Oxidative Coupling for Constructing Polymethoxyphenanthrene Rings. Adv. Synth. Catal. 2012, 354, 383–387.