个人简历

学科方向\t 生物化学与分子生物学
沈月全教授，药物化学生物学国家重点实验室副主任。2007年教育部新世纪优秀人才，973首席科学家，中国晶体学会理事，中国生物物理学会理事，分子生物物理分会理事，膜生物学分会理事。1995年本科毕业于北京科技大学应用化学系。2000年7月在中国科学院生物物理研究所获博士学位。其后在美国Brandeis University和University of Chicago从事博士后研究，2006年7月任University of Chicago研究助理教授。2006年10月从美国芝加哥大学作为特殊人才引进加盟南开大学。主要研究钙离子跨膜运输和传导的分子机理。主持973项目，国家自然科学基金等。在Nature, Nat Comm, Mol Cell, EMBO J, PNAS 等国际著名杂志上发表论文多篇。

研究领域

钙离子的信号传导""

近期论文

1. Xing, Y., Wang, M., Wang, J., Nie, Z., Wu, G., Yang, X.*, Shen, Y.* (2019) Dimerization of MICU proteins controls Ca2+ influx through the mitochondrial Ca2+ uniporter. Cell Report. 26(5):1203-1212. 2. Wu, G., Yang, X.,Shen, Y.* (2018) Identification of a single aspartate residue critical for both fast and slow calcium-dependent inactivation of the human TRPML1 channel. J. Biol. Chem., 293(30):11736-11745 3. Li, X., Wu, G., Yang, Y., Fu, S., Liu, X., Kang, H., Yang. X.*, Su, X.*, Shen, Y.* (2017) Calmodulin dissociates the STIM1-Orai1 complex and STIM1 oligomers. Nat. Comm., 8(1), 1042. 10.1038/s41467-017-01135-w 4. Wang, L., Yang, X., Shen, Y.* (2015) Molecular mechanism of mitochondrial calcium uptake. Cell. Mol. Life Sci., 72(8), 1489-1498. Invited Review. 5. Xu, H., Lin, Z., Li, F., Diao, W., Dong, C., Xie, X., Wang, Z., Shen, Y.*, Long, J.* (2015) Dimerization of Elp1 is essential for Elongator complex assembly, Proc. Natl. Acad. Sci. USA, 112(34):10697-702. 6. Wang, L., Yang, X., Wang, Z., Liu, Y., Feng, J. Zhu, Y., Shen, Y.* (2014) Structural and Mechanistic Insights into MICU1 Regulation of Mitochondrial Calcium Uptake. EMBO J, 33(6), 594-604. 7. Xie, X., Yan, X., Wang, Z., Zhou, H., Diao, W., Zhou, W., Long, J.*, Shen, Y.* (2013) Open-Closed Motion of Mint2 Regulating APP Metabolism, J. Mol. Cell Biol., 5(1), 48-56. 8. Chu, X., Qin, X., Li, L., Wang, Z., Li, F., Zhou, H., Shen, Y.*, Long, J.* (2013) Structural insights into Paf1 complex assembly and histone binding. Nucleic Acid. Res. 41(22):10619-29. 9. Yang, X., Jin, H., Cai, X., Li, S., Shen, Y.* (2012) Structural and Mechanistic Insights into the Activation of STIM1, Proc. Natl. Acad. Sci. USA, 109(15), 5657–5662. (Selected by Faculty of 1000 Biology) 10. Wang, Z., Yang, X., Chu, X., Zhou, H., Shen, Y.*, Long J.* (2012) The structural basis for the oligomerization of the N-terminal domain of SATB1. Nucleic Acids Res., 40(9):4193-202.