个人简历

学科方向\t 纳微尺度细胞成像与操控
简 介\t
潘雷霆，男，南开大学物理科学学院教授、博导，主要从事基于纳微光学技术的细胞成像与操控研究，包括超分辨光学成像、光刻细胞图案化操控、光生物学效应等生物与光学交叉领域的科学研究。2004年获南开大学物理学院生物物理专业学士学位，2009年获南开大学物理学院光学专业博士学位，随后留校工作至今。2010年5月-8月作为访问学者在美国加州大学洛杉矶分校交流学习，2015年12月至2016年12月作为访问学者在美国加州大学伯克利分校交流学习。2015年入选天津市“131”创新型人才培养工程，2018年入选“南开大学百名青年学科带头人培养计划”。作为主持人承担国家自然科学基金3项、天津市自然科学基金1项、教育部新教师博士点基金项目1项和中央高校基本科研业务费1项。以第一或者通讯作者在Advanced Science, Cell Reports, Biophysical Journal等杂志发表SCI/EI收录论文28篇。个人主页：http://panltlab.org/

研究领域

1. 搭建新型超分辨光学成像系统 2. 细胞骨架（红细胞，真核细胞）超分辨成像 3. 免疫识别与逃逸相关膜蛋白超分辨成像 4 图案化控制的细胞器互作研究""

近期论文

[34] Fulin Xing, Shuang Xun, Yanhan Zhu, Fen Hu, Irena Drevenšek-Olenik, Xinzheng Zhang, Leiting Pan*, Jingjun Xu. Microfluidic assemblies designed for assessment of drug effects on deformability of human erythrocytes Biochem. Biophys. Res. Commun, 2019, in press [33] Fulin Xing, Fen Hu, Jianyu Yang, Leiting Pan*, Jingjun Xu. Structural and functional studies of erythrocyte membrane-skeleton by single-cell and single-molecule techniques Journal of Innovative Optical Health Sciences, 2019,12: 1830004 (Invited Review) [32] Leiting Pan, Rui Yan, Wan Li, Ke Xu*. Super-Resolution Microscopy Reveals the Native Ultrastructure of the Erythrocyte Cytoskeleton. Cell Reports, 2018, 22: 1151-1158 (IF:8.032, 1区，Top Journal) [31] Fulin Xing, Ping Zhang, Pengchong Jiang, Ziyuan Chen, Jianyu Yang, Fen Hu, Irena Drevenšek-Olenik, Xinzheng Zhang, Leiting Pan*, Jingjun Xu*. Characteristics of Intercellular Calcium Waves Communication in Micropatterned Assemblies of Single Cells. ACS Applied Materials & Interfaces, 2018, 10: 2937-2945. (IF:8.097, 1区，Top Journal) [29] Pengchong Jiang, Fulin Xing, Bu Guo, Jianyu Yang, Zheming Li, Wei Wei, Fen Hu, Imshik Lee, Xinzheng Zhang, Leiting Pan*, Jingjun Xu Nucleotide transmitters ATP and ADP mediate intercellular calcium wave communication via P2Y12/13 receptors among BV-2 microglia. PLoS ONE, 2017, 12:e0183114 [28] Cunbo Li, Zheming Li, Shuang Xun, Pengchong Jiang, Rui Yan, Mincai Chen, Fen Hu, Romano A. Rupp, Xinzheng Zhang, Leiting Pan*, Jingjun Xu. Protection of the biconcave profile of human erythrocytes against osmotic damage by ultraviolet-A irradiation through membrane-cytoskeleton enhancement. Cell Death Discovery,2017,3: 17040 [27] Fen Hu, Zhenhai Hui, Wei Wei, Jianyu Yang, Ziyuan Chen, Bu Guo, Fulin Xing, Xinzheng Zhang, Leiting Pan*, Jingjun Xu. Hypotonic stress promotes ATP release, reactive oxygen species production and cell proliferation via TRPV4 activation in rheumatoid arthritis rat synovial fibroblasts. Biochem. Biophys. Res. Commun.,2017, 486:108-115 [24] Wenshuai Jiang, Wei Xin, Shaonan Chen, Cunbo Li, Xiaoguang Gao,Leiting Pan, Zhibo Liu*, Jianguo Tian. Microshell Arrays Enhanced Sensitivity in Detection of Specific Antibody for Reduced Graphene Oxide Optical Sensor. [23] Cunbo Li, Xuechen Shi, Mincai Chen, Xinglei Su, Pengchong Jiang,Leiting Pan*. Ultraviolet light A irradiation induces immunosuppression associated with the generation of reactive oxygen species in human neutrophils. Journal of Innovative Optical Health Sciences,2016,9: 1650001 [22] Tengqian Sun, Qing Ye*, Fen Hu, Shike Liu, Xiaowan Wang, Jin Wang, Zhichao Deng, Jianchun Mei, Wenyuan Zhou, Chunping Zhang, Xinyu Wang, Leiting Pan, Jianguo Tian. Quantitative index imaging of coculture cells by scanning focused refractive index microscopy. Journal of Biomedical Optics,2016,21(8): 086016 [21] Fen Hu, Fulin Xing, Ge Zhu, Cunbo Li, Junle Qu, Imshik Lee, Leiting Pan*. Rhein antagonizes P2X7 receptor in rat peritoneal macrophages. Scientific reports,2015,5: 14012 [20] Fei Xing, Guixian Meng, Qian Zhang, Leiting Pan, Peng Wang, Zhibo Liu*, Wenshuai Jiang, Yongsheng Chen, Jianguo Tian*. Ultrasensitive Flow Sensing of a Single Cell Using Graphene-Based Optical Sensors. Nano Letters,2014,14: 3563-3569 [19] Qingquan Chen, Yiping Zuo, Wei Cai, Bin Zhang, Leiting Pan, Jianghong Yao, Qiang Wu*, Jingjun Xu. Giant field enhancement and resonant wavelength shift through a composite nanostructure. Optics Communications, 2014, 321: 47-50 [18] Fen Hu, Leiting Pan*, Kai Zhang, Fulin Xing, Xinyu Wang, Imshik Lee, Xinzheng Zhang, Jingjun Xu. Elevation of extracellular Ca2+ induces store-operated calcium entry via calcium-sensing receptors: a pathway contributes to the proliferation of osteoblasts. PLoS ONE, 2014, 9: e107217 [17] Shuyan Zhu, Yuxiang Wang, Leiting Pan*, Shuang Yang, Yonglin Sun, Xinyu Wang, Fen Hu. Involvement of transient receptor potential melastatin-8 (TRPM8) in menthol-induced calcium entry, ROS production and cell death in rheumatoid arthritis rat synovial fibroblasts. European Journal of Pharmacology, 2014, 725(1): 1-9 [16] Guixian Meng, Leiting Pan*, Cunbo Li, Fen Hu, Xuechen Shi, Imshik Lee, Irena Drevenšek-Olenik, Xinzheng Zhang, Jingjun Xu. Temperature-induced Labelling of Fluo-3 AM Selectively Yields Brighter Nucleus in Adherent Cells. Biochem. Biophys. Res. Commun.,2014,443: 888-893 [15] Xian Wu, Leiting Pan*, Ying Liu, Mengxi Xing, Xinzheng Zhang, Jingjun Xu. Multi-pathways-mediated propagations of intercellular calcium waves in microglial cells. Progress in Biochemistry and Biophysics，2014, 41(2): 179-184 [14] Leiting Pan, Kun Song, Fen Hu, Wenwu Sun, Imshik Lee. Nitric oxide induces apoptosis associated with TRPV1 channel-mediated Ca2+ entry via S-nitrosylation in osteoblasts. European Journal of Pharmacology,2013,715(1):280-285 [13] Xian Wu, Leiting Pan*, Ying Liu, Pengchong Jiang, Imshik Lee, Irena Drevensek-Olenik, Xinzheng Zhang, Jingjun Xu. Cell–cell communication induces random spikes of spontaneous calcium oscillations in multi-BV-2 microglial cells. Biochem. Biophys. Res. Commun.,2013,431:664-669 [12] Leiting Pan*, Xiaoxu Wang, Shuying Yang, Xian Wu, Imshik Lee, Xinzheng Zhang, Romano A. Rupp, Jingjun Xu. Ultraviolet irradiation-dependent fluorescence enhancement of hemoglobin catalyzed by reactive oxygen species. PLoS ONE, 2012, 7(8): e44142 [11] Ting-Hsuan Chen, Xiaolu Zhu#,Leiting Pan#, Xingjuan Zeng, Alan Garfinkel, Yin Tintut, Linda L. Demer, Xin Zhao and Chih-Ming Ho. (#Contributed Equally) Directing Tissue morphogenesis via Self-Assembly of Vascular Mesenchymal Cells. Biomaterials, 2012, 33: 9019-9026 [10] Songzi Kou, Leiting Pan*, Danny van Noort, Guixian Meng, Xian Wu, Haiying Sun, Jingjun Xu, Imshik Lee. A multishear microfluidic device for quantitative analysis of calcium dynamics in osteoblasts. Biochem. Biophys. Res. Commun.,2011,408:350-355 [9] Leiting Pan*, Xian Wu, Dan Zhao, Nason Ma’ani Hessari, Imshik Lee, Xinzheng Zhang, Jingjun Xu. Sulfhydryl Modification Induces Calcium Entry through IP3-sensitive Store-operated Pathway in Activation-dependent Human Neutrophils. PLoS ONE, 2011, 6:e25262 2010 [8] Xian Wu, Leiting Pan*, Zhenhua Wang, Xiaoli Liu, Dan Zhao, Xinzheng Zhang, Romano A. Rupp, Jingjun Xu. Ultraviolet irradiation induces autofluorescence enhancement via production of reactive oxygen species and photodecomposition in erythrocytes. Biochem. Biophys. Res. Commun., 2010, 396: 999-1005 [7] Wenwu Sun, Leiting Pan, Zhuang Ma*. Hypo-osmotic stress enhances the uptake of polyethylenimine/oligonucleotides complexes in A549 cells via Ca2+ mobilization from intracellular stores. Oligonucleotides, 2010, 20: 111-115 [6] Xu Zhang, Xiaoli Liu, Leiting Pan, Imshik Lee*. Magnetic Fields at Extremely Low-Frequency (50 Hz, 0.8 mT) Can Induce the Uptake of Intracellular Calcium Levels in Osteoblasts. Biochem. Biophys. Res. Commun., 2010, 396: 662-666 [5] Wei Li, Baiquan Tang, Xinzheng Zhang, Feng Gao, Longchang Liu, Qiang Wu, Leiting Pan, Cibo Lou, Shangyu Guo, Romano A. Rupp, Jingjun Xu*, Baiquan Tang. Investigation on the phase shift of extinction and phase gratings in Polymethyl methacrylate. Chinese Optics Letters, 2010, 8: 18-21
担任中国微循环学会血液治疗专业委员会常委、中国光学学会生物医学光子学专业委员会青年委员、中国生物物理学会自由基生物学与自由基医学分会青年委员。任《British Journal of Pharmacology》、《Journal of Photochemistry and Photobiology》、《中国激光》和《光学学报》等杂志审稿人