个人简历

学科方向\t 药物设计的结构基础

研究领域

与病毒相关的蛋白质结构与功能；与肿瘤相关的蛋白质结构与功能；基于蛋白质结构的新型药物设计""

近期论文

1.Che S., Chen Y., Liang Y., Zhang Q., Bartlam M. Crystal structure of RecR, a member of the RecFOR DNA-repair pathway, from Pseudomonas aeruginosa PAO1. (2018) Acta Crystallographica Section:F Structural Biology Communications, 74, pp. 222-230. 2. Wu, Z., Xie, M., Li, Y., Gao, G., Bartlam, M., Wang, Y. Biodegradation of decabromodiphenyl ether (BDE 209) by a newly isolated bacterium from an e-waste recycling area (2018) AMB Express, 8 (1), 27. 3. Wu, Z., Bartlam, M., Wang, Y.Complete genome sequence of Stenotrophomonas sp. strain WZN-1, which is capable of degrading polybrominated diphenyl ethers (2017) Genome Announcements, 5 (31), e00722-17. 4. Li, S., Teng, X., Su, L., Mao, G., Xu, Y., Li, T., Liu, R., Zhang, Q., Wang, Y., Bartlam, M. Structure and characterization of a NAD(P)H-dependent carbonyl reductase from Pseudomonas aeruginosa PAO1 (2017) FEBS Letters, 591 (12), pp. 1785-1797. 5. Xu, J., Wang, M., Sun, X., Ren, Q., Cao, X., Li, S., Su, G., Tuerhong, M., Lee, D., Ohizumi, Y., Bartlam, M., Guo, Y. Bioactive Terpenoids from Salvia plebeia: Structures, NO Inhibitory Activities, and Interactions with iNOS (2016) Journal of Natural Products, 79 (11), pp. 2924-2932. 6. Han, T., Zhao, Z., Bartlam, M., Wang, Y. Combination of biochar amendment and phytoremediation for hydrocarbon removal in petroleum-contaminated soil (2016) Environmental Science and Pollution Research, 23 (21), pp. 21219-21228. 7. Ji, Y., Postis, V.L.G., Wang, Y., Bartlam, M., Goldman, A. Transport mechanism of a glutamate transporter homologue GltPh (2016) Biochemical Society Transactions, 44 (3), pp. 898-904. 8. Hao, Z., Thomsen, M., Postis, V.L.G., Lesiuk, A., Sharples, D., Wang, Y., Bartlam, M., Goldman, A. A novel and fast purification method for nucleoside transporters (2016) Frontiers in Molecular Biosciences, 3 (JUN), 23. 9. Xu, J., Sun, X., Liu, X., Peng, M., Li, S., Jin, D.-Q., Lee, D., Bartlam, M., Guo, Y. Phytochemical constituents from Melicope pteleifolia that promote neurite outgrowth in PC12 cells (2016) Journal of Functional Foods, 23, pp. 565-572. 10. Liu, J., Hao, Z., Ma, L., Ji, Y., Bartlam, M., Wang, Y. Spatio-temporal variations of high and low nucleic acid content bacteria in an exorheic river (2016) PLoS ONE, 11 (4), e0153678. 11. Zhang, Q., Yan, D., Guo, E., Ding, B., Yang, W., Liu, R., Yamamoto, T., Bartlam, M. Structural basis for inhibition of the deadenylase activity of human CNOT6L (2016) FEBS Letters, 590 (8), pp. 1270-1279. 12. Ma, L., Mao, G., Liu, J., Gao, G., Zou, C., Bartlam, M.G., Wang, Y. Spatial-temporal changes of bacterioplankton community along an exhorheic river (2016) Frontiers in Microbiology, 7 (MAR), 论文编号 250, . 13. Ma, D., Hao, Z., Sun, R., Bartlam, M., Wang, Y. Genome sequence of a typical ultramicrobacterium, Curvibacter sp. strain PAE-UM, capable of phthalate ester degradation (2016) Genome Announcements, 4 (1), e01510-15. 14. Zhang, A., Guo, E., Qian, L., Tang, N.-Y., Watt, R.M., Bartlam, M. Purification, crystallization and X-ray crystallographic analysis of a putative exopolyphosphatase from Zymomonas mobilis(2016) Acta Crystallographica Section:F Structural Biology Communications, 72, pp. 172-178. 15. Bai, Y., Tashiro, S., Nagatoishi, S., Suzuki, T., Yan, D., Liu, R., Tsumoto, K., Bartlam, M., Yamamoto, T. Structural basis for inhibition of the Tob-CNOT7 interaction by a fragment screening approach (2015) Protein and Cell, 6 (12), pp. 924-928. 16. Xie, C., Sun, L., Liao, K., Liu, S., Wang, M., Xu, J., Bartlam, M., Guo, Y. Bioactive ent-Pimarane and ent-Abietane Diterpenoids from the Whole Plants of Chloranthus henryi (2015) Journal of Natural Products, 78 (11), pp. 2800-2807. 17. Li, S., Li, T., Xu, Y., Zhang, Q., Zhang, W., Che, S., Liu, R., Wang, Y., Bartlam, M. Structural insights into YfiR sequestering by YfiB in Pseudomonas aeruginosa PAO1 (2015) Scientific Reports, 5, 16915. 18. Ma, C., Hao, Z., Huysmans, G., Lesiuk, A., Bullough, P., Wang, Y., Bartlam, M., Phillips, S.E., Young, J.D., Goldman, A., Baldwin, S.A., Postis, V.L.G. A Versatile Strategy for Production of Membrane Proteins with Diverse Topologies: Application to Investigation of Bacterial Homologues of Human Divalent Metal Ion and Nucleoside Transporters (2015) PLoS ONE, 10 (11), e0143010. 19. Xie, C., Wang, H., Sun, X., Meng, L., Wang, M., Bartlam, M., Guo, Y. Isolation, Characterization, and Antiproliferative Activities of Eudesmanolide Derivatives from the Flowers of Inula japonica (2015) Journal of Agricultural and Food Chemistry, 63 (41), pp. 9006-9011. 20. Liu, J., Yu, Y., Cai, Z., Bartlam, M., Wang, Y. Comparison of ITS and 18S rDNA for estimating fungal diversity using PCR–DGGE (2015) World Journal of Microbiology and Biotechnology, 31 (9), pp. 1387-1395.