个人简历

学科方向\t 药物设计的结构基础
龙加福，教育部新世纪优秀人才，第十三届天津青年科技奖获得者。1999年06月获南开大学生物化学学士学位,2004年08月获香港科技大学生物化学博士学位，2004年09月在香港科技大学开始博士后训练。博士学位及博士后研究都是在张明杰院士的指导下完成。
龙加福教授自2007年01月独立主持实验室以来，运用多学科交叉的手段和方法系统地研究蛋白质或复合物的结构与功能，现主要研究方向是基因表达调控与疾病，相对系统的研究了组蛋白修饰复合物的装配机理及染色质变构的调节机制。研究成果阐明了参与组蛋白修饰的Elongator复合物装配的分子机制和PAF1复合物特异识别组蛋白底物的作用机理。揭示了染色质变构因子SATB1多聚化的分子机制及其多聚化参与调节染色质高级结构的可能作用机理。从生物化学及结构生物学的角度推动了多蛋白功能复合物参与基因表达调控的表观遗传学机制，为科学发展做出了一定贡献。主持973计划子课题、国家自然科学基金、天津市自然科学基金重点项目等。科研论文主要发表在Nat Struct Mol Biol、PNAS、Cell Res、Angew Chem Int Ed、Nucleic Acids Res、Structure和JBC等国际知名杂志。

研究领域

运用生物化学、结构生物学、分子及细胞生物学的手段和方法来研究蛋白质的结构与功能""

近期论文

1.“Supramodular structure and synergistic target binding of the N-terminal tandem PDZ domains of PSD-95”, Long, J., Tochio, H., Wang, P., Fan J.-S,. Sala, C., niethammer, M., Sheng, M. and Zhang, M., J. Mol. Biol., 327(1): 203-214 (2003). 2.“The tetrameric L27 domain complex as an organization platform for supramolecular assemblies”, Feng, W.&,Long, J.&(equal contribution), Fan, J,-S., Suetake, T., Zhang, M., Nat. Struct. Mol. Biol., 11(5):475-480 (2004). 3． “A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins”, Feng, W.&, Long, J.&(equal contribution), Zhang, M.,Proc. Natl. Acad. Sci. USA, 102(19): 6861-6866 (2005). 4.“Autoinhibition of X11/Mint Scaffold Proteins Revealed by the Closed Conformation of the PDZ Tandem”, Long, J., Feng, W., Wang, R., Chan, L.-N., Fanny, Ip. Xia, J., Nancy, Ip. Zhang, M., Nat. Struct. Mol. Biol., 12(8): 722-728 (2005). 5.“Supramodular nature of GRIP1 revealed by the structure of its PDZ12 tandem in complex with the carboxyl tail of Fras1”, Long, J., Wei, Z., Feng, W., Yu, C., Zhao, Y. –X., Zhang, M., J. Mol. Biol., 375(5):1457-1468 (2008). 6.“Structural basis of b-catenin Recognition by Tax-interaction Protein-1”, Zhang, J., Yan, X., Shi, C., Yang, X., Guo, Y., Tian, C., Long, J.*, Shen, Y.*, J. Mol. Biol., 384(1): 255-263 (2008). (*: Co-corresponding author). 7. “Molecular Mechanism of Inward Rectifier Potassium Channel 2.3 Regulation by Tax-interacting Protein-1”, Yan, X., Zhou, H., Zhang, J., Shi, C., Xie, X., Wu, Y., Tian, C., Shen, Y.*, Long, J.*, J. Mol. Biol., 392(4): 967-976 (2009). 8. “Structural basis for tandem L27 domain-mediated polymerization”, Yang, X., Xie, X., Chen, L., Zhou, H., Wang, Z., Zhao, W., Tian, R., Zhang, R., Tian, C., Long. J.*, Shen, Y.*, FASEB J., 24(12): 4806-4815 (2010). 9. “The structural basis for the oligomerization of the N-terminal domain of SATB1”, Wang, Z., Yang, X., Chu, X., Zhang, J., Zhou, H., Shen, Y.*, Long, J.*, Nucleic Acids Res., 40(9): 4193-4202 (2012). 10. “Structure of an L27 domain heterotrimer from the cell polarity complex Patj/Pals1/Mals2 reveals a mutually independent L27 domain assembly mode”, Zhang, J., Yang, X., Wang, Z., Zhou, H., Xie, X., Shen, Y.*, Long, J.*, J. Biol. Chem., 287(14): 11132-11140 (2012). 11. “Rational design of a tetrameric Protein to enhance interactions between self-assembled fibers confers molecular hydrogels”, Zhang, X., Chu, X., Wang, L., Wang, H., Liang, G., Zhang, J., Long, J.*, Yang, Z.*, Angew. Chem. Int. Ed., 51(18): 4388-4392 (2012). 12. “Crystal structure of Elongator subcomplex Elp4-6”, Lin, Z., Zhao, W., Diao, W., Xie, X., Wang, Z., Zhang, J., Shen, Y.*, Long, J.*, J. Biol. Chem.287(25): 21501-21508 (2012). 13. “Open-closed mechanism of Mint2 regulates APP metabolism”, Xie, X., Yan, X., Wang, Z., Zhou, H., Diao, W., Zhou, W., Long, J.*, Shen, Y.*, J. Mol. Cell Biol.5(1): 48-56 (2013). 14. “Multifunctional biohybrid hydrogels for cell culture and cotrolled drug release”, Wang, H., Han, A., Cai, Y., Xie, Y., Zhou, H.*, Long, J.*, Yang, Z.*, Chem. Commun., 49(67): 7448-7450 (2013). 15. “Growth stimulation of bacterium Delftia by a peptide hydrogel”, Du, X., Wu, Z.,Long, J.*, Wang, L.*, RSC Adv., 3(40): 18259-18262 (2013). 16. “Structural insights into Paf1 complex assembly and histone binding”, Chu, X., Qin, X., Xu, H., Li, L., Wang, Z., Li, F., Xie, X., Zhou, H., Shen Y.*, Long, J.*, Nucleic Acids Res., 41(22): 10619-10629 (2013). 17. “Rational design of multifunctional hetero-hexameric proteins for hydrogel formation and controlled delivery of bioactive molecules”, Zhang, X., Zhou, H., Xie, Y., Ren, C., Ding, D.*, Long, J.*, Yang, Z.*, Adv. Healthc. Mater., 3(11): 1804-1811 (2014). 18. “Crystal structure of the Ubiquitin-like domain-CUT repeat-like tandem of special AT-rich sequence binding protein 1 (SATB1) reveals a coordinating DNA-binding mechanism”, Wang, Z., Yang, X., Guo, S., Yang, Y., Su, X-C., Shen, Y.*, Long, J.*, J. Biol. Chem., 289(40): 27376-27385 (2014). 19. “A genetically modified protein-based hydrogel for 3D culture of AD293 cells”, Du, X., Wang, J., Diao, W., Wang, L., Long, J.*, Zhou, H.*, PLoS One, 9(9): e107949 (2014). 20. “The Elp2 subunit is essential for Elongator assembly and functional regulation”, Dong, C., Lin, Z., Diao, W., Li, D., Chu, X., Wang, Z., Zhou, H., Xie, Z., Shen, Y.*, Long, J.*, Structure, 23(6): 1078-1086(2015).