个人简历
学科方向\t 生物化学与分子生物学\t 简 介\t 孔德领，南开大学生命科学学院教授，博士生导师。1989年7月于南开大学化学系获得学士学位；1992年于南开大学高分子化学研究所获得高分子化学与物理硕士学位；1997年于南开大学分子生物学研究所获得高分子化学与物理博士学位。1998年9月至2000年8月在德国罗斯托克大学生物工程中心进行博士后训练，2000年9月至2003年8月在美国哈佛大学医学院进行博士后训练，2003年回国。2007年获得国家杰出青年科学基金，自2004年至今担任生物活性材料教育部重点实验室主任。入选国家百千万人才工程，获得国务院政府特殊津贴，任中国生物医学工程学会常务理事，中国生物材料学会常务理事，中国材料学会理事，“心血管组织工程”教育部创新团队带头人。从事心血管生物材料和组织工程研究，主要开展小口径人工血管、干细胞治疗和相关活性多肽水凝胶与干细胞分子探针研究。近年来主持973项目课题2项、国家自然科学基金重点项目4项、以及其他多项国家和省部级科研项目。获得国家科技进步二等奖、天津市自然科学一等奖和二等奖等。发表SCI收录论文200余 篇，他人SCI引用3000余次, H Index 29。代表论文包括Nature Medicine, Circulation, J Am Chem Soc., Angew Chem Int Ed Engl., ACS Nano., Biomaterials, Journal of Controlled Release, Cardiovascular Research等。获得中国授权发明专利十余项。
研究领域
生物医学材料、组织工程""
近期论文
（1）Dong X, Yuan X, Wang L, Liu J, Midgley AC, Wang Z, Wang K, Liu J, Zhu M*, Kong D*. Construction of a bilayered vascular graft with smooth internal surface for improved hemocompatibility and endothelial cell monolayer formation. Biomaterials. 2018 Jul 20;181:1-14. （2）Zhu M, Wu Y, Li W, Dong X, Chang H, Wang K, Wu P, Zhang J, Fan G, Wang L, Liu J, Wang H*, Kong D*.Biodegradable and elastomeric vascular grafts enable vascular remodeling.Biomaterials. 2018 Nov;183:306-318. doi: 10.1016/j.biomaterials.2018.08.063. Epub 2018 Sep 1. （3）Yang P, Song H, Qin Y, Huang P, Zhang C, Kong D*, Wang W*. Engineering Dendritic-Cell-Based Vaccines and PD-1 Blockade in Self-Assembled Peptide Nanofibrous Hydrogel to Amplify Antitumor T-Cell Immunity. Nano Lett. 2018 Jul 11;18(7):4377-4385. （4）Duo Mao, Fang Hu, Kenry, Shenglu Ji, Wenbo Wu, Dan Ding, Deling Kong*, Bin Liu*. Metal-organic framework-assisted in vivo bacterial metabolic labeling and precise antibacterial therapy. Advanced Materials. 2018 May;30(18):e1706831. （5）Jimin Zhang, Huijuan Song, Shenglu Ji, Xiaomin Wang, Pingsheng Huang, Chuangnian Zhang, Weiwei Wang*, Deling Kong*. NO prodrug-conjugated, self-assembled, pH-responsive and galactose receptor targeted nanoparticles for co-delivery of nitric oxide and doxorubicin. Nanoscale. 2018 Mar 1;10(9):4179-4188. （6）Xiaomin Wang, Jimin Zhang, Weilong Cui, Yuan Fang, Li Li, Shenglu Ji, Duo Mao, Tingyu Ke, Xin Yao, Dan Ding, Guowei Feng*, Deling Kong*. Composite hydrogel modified by IGF-1C domain improves stem cell therapy for limb ischemia. ACS Applied Materials & Interfaces. 2018 Feb 7;10(5):4481-4493. （7）Huijuan Song, Pingsheng Huang, Jinfeng Niu, Gaona Shi, Chuangnian Zhang, Deling Kong*, Weiwei Wang*. Injectable polypeptide hydrogel for dual-delivery of antigen and TLR3 agonist to modulate dendritic cells in vivo and enhance potent cytotoxic T-lymphocyte response against melanoma. Biomaterials 2018 Jan 3;159:119-129. （8）Mao D, Liu J, Ji S, Wang T, Hu Y, Zheng D*, Yang R, Kong D*, Ding D*. Amplification of near-infrared fluorescence in semiconducting polymer nanoprobe for grasping the behaviors of systemically administered endothelial cells in ischemia treatment. Biomaterials. 2017 Oct;143:109-119. （9）Wang Z, Wu Y, Wang J, Zhang C, Yan H, Zhu M, Wang K*, Li C, Xu Q, Kong D*. Effect of Resveratrol on Modulation of Endothelial Cells and Macrophages for Rapid Vascular Regeneration from Electrospun Poly(ε-caprolactone) Scaffolds. ACS Appl Mater Interfaces. 2017 Jun 14;9(23):19541-19551. （10）Xin Zhou, He Wang, Jimin Zhang, Xuemei Li, Yifan Wu, Yongzhen Wei, Ji Shenglu, Deling Kong*, Qiang Zhao*. Functional poly(ε-caprolactone)/chitosan dressings with nitric oxide-releasing property improve wound healing. Acta Biomaterialia. 2017 May;54:128-137. （11）Gaona Shi, Chuangnian Zhang, Rong Xu, Jinfeng Niu, Huijuan Song, Xiuyuan Zhang, Weiwei Wang, Yanming Wang, Chen Li*, Xiaoqing Wei*, Deling Kong*. Enhanced antitumor immunity by targeting dendritic cells with tumor cell lysate-loaded chitosan nanoparticles vaccine. Biomaterials, 2017;113:191-202 （12）Kai Wang, Qiuying Zhang, Liqiang Zhao, Yiwa Pan, Ting Wang, Dengke Zhi, Shaoyang Ma, Peixin Zhang, Tiechan Zhao, Siming Zhang, Wen Li, Meifeng Zhu, Yan Zhu, Jun Zhang*, Mingqiang Qiao*, Deling Kong*. Functional Modification of Electrospun PCL Vascular Grafts with the Fusion Protein VEGF-HGFI for Enhanced Vascular Regeneration. ACS Appl Mater Interfaces. 2017 Apr 5;9(13):11415-11427. （13）Chuangnian Zhang, Gaona Shi, Ju Zhang, Jinfeng Niu, Pingsheng Huang, Zhihong Wang, Yanming Wang, Weiwei Wang, Chen Li*, Deling Kong*. Redox- and light-responsive alginate nanoparticles as effective drug carriers for combinational anticancer therapy. Nanoscale, 2017 Mar 2;9(9):3304-3314. （14）Chuangnian Zhang, Gaona Shi, Ju Zhang, Huijuan Song, Jinfeng Niu, Shengbin Shi, Pingsheng Huang, Yanming Wang, Weiwei Wang, Chen Li*, Deling Kong*. Targeted antigen delivery to dendritic cell via functionalized alginate nanoparticles for cancer immunotherapy. Journal of Controlled Release. 2017 Jun 28;256:170-181.
