个人简历

学科方向\t 药物靶标的疾病分子机制研究
洪章勇教授，1997年本科毕业于中国科技大学应用化学系，获学士学位。同年推荐至中科院上海有机化学研究所，2002年毕业获有机化学博士学位，博士期间从事天然产物有机合成研究。随后于2003到2008期间，在美国Scripps研究所化学生物学系进行博士后训练，师从美国科学院院士Chi-Huey Wong教授（Wolf奖得主），从事糖化学与生物学方面的研究，以及蛋白质的基因工程方面的研究。2009年加入到南开大学生命科学学院，从事生物医药方面的研究，现为南开大学生命科学学院教授，生物化学与分子生物学系主任，博士生导师。目前承担国家自然科学基金和天津市科技支撑计划重点项目多项，主持南开大学新药创制计划，参与多项国家科技部973项目研究。
洪章勇实验室主要研究方向是生物技术药物研究，侧重蛋白质/多肽以及它们的缀合物类的药物，通过综合利用化学与生物的技术，发展有临床治疗潜力的药物及疫苗。具体如下：1. 抗肿瘤靶向药物研究，包括免疫毒素类药物，设计毒素蛋白与靶向抗体偶联，进行抗肿瘤的治疗；光敏药物，设计新型的光敏化合物，并通过抗体/多肽的修饰实现肿瘤的特异传输，进行肿瘤高选择性的光动力治疗。2.环状活性多肽库的构建及用于药物的高通量筛选：发展基于mRNA展示高通量筛选技术，结合化学修饰手段，构建大容量高稳定的环肽环肽化合物，用于生物学用途的筛选。3.疫苗的研究：发展基于酵母多糖为载体的抗原递呈新方法，能同时高效激活体液免疫和细胞免疫，用于治疗性疫苗的开发。

研究领域

生物化学，化学生物学，生物医药""

近期论文

1.Hui Liu, Zhenghu Jia, Chengmao Yang, Mei Song, Zhe Jin , Zhenzhou Wu, Liqing Zhao, Dongsheng Wei,* Zhinan Yin,* Zhangyong Hong,* Aluminum hydroxide colloid vaccine encapsulated in yeast shell with enhanced humoral and cellular immunity response. Biomaterials, 2018, 167, 32-43. (IF 8.4) 2.Wenjing Li, Sihai Tan, Yutong Xing, Qian Liu, Shuang Li, Qingle Chen, Min Yu,* Fengwei Wang,* Zhangyong Hong,* cRGD peptide conjugated pyropheophor¬bide-a photosensitizers for tumor targeting photodynamic therapy. Mol. Pharm., 2018， 15， 1505-1514. (IF 4.5). 3.Kai Wang,* Yupeng Feng, Shuang Li, Wenjing Li, Xi Chen, Ran Yi, Hongru Zhang, Zhangyong Hong,* Oral delivery of bavachinin-loaded PEG-PLGA nanoparticles for asthma treatment in a murine model. J. Biomed. Nanotech., 2018, accepted. (IF 4.5). 4.Qingle Chen, Yanhong Ma, Jisi Zhao, Mei Zhao, Wenjing Li, Qian Liu, Li Xiong,* Wenjie Wu,* and Zhangyong Hong*, In vitro and in vivo evaluation of improved EGFR targeting peptide-conjugated phthalocyanine photosensitizer for tumor photodynamic therapy. Chinese Chem. Lett., special issue，2018, accepted. (IF 1.9). 5.Q. Liu, M. Pang, S. Tan, J. Wang, Q. Chen, K. Wang,* W. Wu* and Z. Hong*. Potent peptide-conjugated silicon phthalocyanines for tumor photodynamic therapy. J. Cancer., 2018. 2018; 9(2): 310-320. (IF 2.9). 6.Min Yu, Ke Wang, Han Zhang, Qian Liu, Jin Wang, Li Cao, Wenjing Li, Kai Wang,* Zhangyong Hong,* DOTAP-incorporated PEG-PLGA nanoparticles for efficient in vitro and in vivo gene delivery. J. Biomed. Nanotech. 2018, 14, 281–293. (IF 4.5). 7.Z. Chen, F. Liu, Y. Chen, J. Liu, X. Wang, A. T. Chen, G. Deng, H. Zhang, J. Liu, Z. Hong,* and J. Zhou.* Targeted Delivery of CRISPR/Cas9-Mediated Cancer Gene Therapy via Liposome-Templated Hydrogel Nanoparticles. Adv. Funct. Mater., 2017, 1703036 (online). (IF 12.1) 8.Z. Yang, M. Xu, Z. Jia, Y. Zhang, L. Wang, H. Zhang, J. Wang, M. Song, Y. Zhao, Z. Wu, L. Zhao*, Z. Yin* and Z. Hong*. A novel antigen delivery system induces strong humoral and CTL immune responses. Biomaterials, 2017, 134, 51-63. (IF 8.4) 9.J. Wang, Q. Liu, Y. Zhang, H. Shi, H. Liu, W. Guo, Y. Ma, W. Huang* and Z. Hong*. A pyropheophorbide a-based photosensitizer tested for in vivo targeted photodynamic therapy. J. Pharmaceutic Sciences, 2017, 106, 1482-1489. (IF 2.9) 10.J. Wang, X. Cao, H. Zhao, J. Zhao, J. Wei, Q, Li, X. Qi, Z. Yang, L. Wang, H. Zhang, L. Bai, Z. Wu, L. Zhao, Z. Hong* and Z. Yin*. Critical roles of conventional dendritic cells in promoting T cell dependent hepatitis through regulating NKT cells. Clinical and Experimental Immunology, 2017, 188, 127-137. (IF 3.0) 11.H. Jiang, Z. Liang, Y. Ma, D. Kong* and Z. Hong*. G-quadruplex fluorescent probe-mediated real-time rolling circle amplification strategy for highly sensitive microRNA detection. Analytica Chimica Acta, 2016, 114-122. 12.R. Guo, L Cao, W. Guo, H. Liu, H. Xu, Q. Fang* and Z Hong*. HER2-targeted immunotoxins with low nonspecific toxicity and immunogenicity. Biochemical and Biophysical Research Communications, 2016, 475, 93–99. 13.R. Guo, W. Guo, L. Cao, H. Liu, J. Liu, H. Xu, W. Huang,* F. Wang* and Z. Hong.* Fusion of the albumin binding domain to extend the half-life of immunotoxin. Int. J. pharm., 2016, 511, 538-549. 14.H. Liu, M. Zhao, J. Wang, M. Pang, Z. Wu, L. Zhao, Z. Yin* and Z. Hong*. Photodynamic therapy of tumors with Pyro-loaded PEG-PLGA nanoparticles. Int. J. Nanomed., 2016, 4905-4918. 15.F. Li, Q. Liu, Z. Liang, J. Wang, M. Pang, W. Huang, W. Wu*, and Z. Hong*. Synthesis and biological evaluation of peptide-conjugated phthalocyanine photosensitizer with highly hydrophilic modifications. Org. Biomol. Chem., 2016, 14, 3409-3422. 16.Y.-R, Li, Q. Liu, Z. Hong, H.–F. Wang.* Magnetic Separation-assistant Fluorescence Resonance Energy Transfer Inhibition for High Sensitive Probing of Nucleolin. Anal. Chem., 2015, 87 (24), pp 12183–12189. 17.S. Chen, J. Wang, H. Cheng, W. Guo, M. Yu, Z. Zhao, Z. Wu, L. Zhao, Z. Yin*, Z. Hong*. Targeted delivery of NK007 to macrophages to treat colitis. J. Pharmaceutical Sciences, 2015, 104, 2276–2284. 18.Y. Li, J. Wang, X. Zhang, W. Guo, F. Li, M. Yu, X. Kong, W. Wu, Z*. Hong*. Highly water-soluble and tumor-targeted photosensitizers for photodynamic therapy. Org. Biomol. Chem., 2015, 13, 7681-7694. 19.Y. Wei, J. Li, Z. Chen, F. Wang, W. Huang, Z. Hong*, J. Lin*. Multistage virtual screening and identification of novel HIV-1 protease inhibitors by integrating SVM, Shape, Pharmacophore and Docking methods. Eur. J. Med. Chem., 2015, 101, 409-418. 20.M. Yu, Z. Chen, W. Guo, J. Wang, Y. Feng, X. Kong, Z. Hong*. Specifically targeted delivery of protein to phagocytic macrophages. Int. J. Nanomed., 2015, 10, 1743-1757.