个人简历

学科方向\t 药物分子的传输
冯喜增，1982毕业于天津医科大学药学专业，获学士学位。1996年获南开大学分析化学博士学位。1996-1998年，中国科学院化学研究所纳米科学和纳米技术实验室，博士后。1998年至2003年，分别在美国亚利桑那州立大学、英国诺丁汉大学药学院、葛兰素史克必成制药公司任博士后高级研究员。2003年回国，南开大学特聘教授，任职于生命科学学院、生物活性材料教育部重点实验室、药物化学生物学国家重点实验室。
冯喜增教授实验团的研究方向：（1）模式脊椎动物（鱼-啮齿类）的神经科学与行为学研究。①利用模式生物斑马鱼睡眠觉醒行为筛选出具有抗抑郁效果的中药处方Scientific reports,2014，评价纳米粒子毒性Small，2013；Scientific reports,2014，与筛选抗癫痫类药物。②应用鼠类进行认知与学习记忆行为机理与机制研究（2）脊髓与骨的组织工程与再生医学研究。运用不同特性的生物活性材料通过3D打印技术构建脊髓与骨的支架，进行脊髓-骨损伤修复研究。（3）菌群感应与监测分析：接触微压印微加工技术，构建微生物反应器，研究菌间信息交流机制。在国内外学术期刊上发表论文72篇，其中SCI已收录 68篇，EI已收录12篇，（包括Angewandte Chemie International Edition，Small, Nucleic Acid Research, Scientific reports , J Mol Biol., ACS Nano, Chemistry of Material, Chemical Communications, Biosensors & Bioelectronics, Langmuir, J Materials Chem., Electrophoresis等）。已获发明专利授权2项；编著、合作出版学术著作2部。

研究领域

新材料学、纳米生物学""

近期论文

1. Du Shuangli #, Wang Hongyu #, Yang Yueyue, Feng Xizeng*, Shao Xueguang, Chipot Christophe, and Cai Wensheng *. Curvature of Buckybowl Corannulene Enhances Its Binding to Proteins. THE JOURNAL OF PHYSICAL CHEMISTRY C, 2018, 123.1: 922-930. 2. Li Meng, Liu Xing-Yu, Feng Xi-Zeng*, Cardiovascular toxicity and anxiety-like behavior induced by deltamethrin in zebrafish (Danio rerio) larvae, CHEMOSPHERE, 2019, 219: 155-164 3. Mi Ping #, Zhang Qiu Ping #, Li Shi Bao, LiuXing-Yu, Zhang Shu-Hui, Li Meng, Chen Dong-Yan*, Zhao Xin*, Feng Dao-Fu*, Feng Xi-Zeng*, Melatonin protects embryonic development and maintains sleep/wake behaviors from the deleterious effects of fluorene‐9‐bisphenol in zebrafish (Danio rerio), JOURNAL OF PINEAL RESEARCH, 2018: e12530 4.Liu Xing-Yu #, Zhang Qiu-Ping #, Li Shi-Bao #, Mi Ping, Chen Dong-Yan*, Zhao Xin*, Feng Xi-Zeng*, Developmental toxicity and neurotoxicity of synthetic organic insecticides in zebrafish (Danio rerio): A comparative study of deltamethrin, acephate, and thiamethoxam, CHEMOSPHERE, 2018, 199: 16-25 5.Jia Zhenzhen #, Feng Zeyang #, Wang Lining, Li Hao, Wang Hongyu, Xu Ding qi, Zhao Xin*, Feng Daofu*, Feng Xizeng*, Resveratrol reverses the adverse effects of diet-induced obese murine model on oocyte quality and zona pellucida softening, FOOD & FUNCTION, 2018, 9 (5): 2623-2633 1. Li, XY (Li, Xinyu); Sun, DD (Sun, Dandan); Li X (Li, Xu); Zhang, DX (Dashuai); Jao, JJ (Jiao, Jiajia); Wang, K (Wang, Kai); Kong, DL (Kong, Deling); Zhao, X (Zhao, Xin); Xu, L* (Xu, Lin); Zhao, Q* (Zhao, Qing); Chen, DY* (Chen, Dongyan); Feng, XZ* (Feng, Xizeng). PEGylation corannulene enhances response of stress through promoting neurogenesis. BIOMATERIALS SCIENCE, 2017, 5(4): 849-859. 2. Li, XY (Li, Xinyu); Wang, HY (Wang, Hongyu); Kuang, XH (Kuang, Xiangyu); Ma, JR (Ma, Jingrui);Feng, XZ* (Feng, Xizeng). Exploring the effects and mechanisms of carbon nanomaterial diversity on the morphology of lysozyme crystals. CRYSTENGCOMM, 2017, 19(39): 5873-5881. 3. Zhang, SH (Zhang, Shuhui); Xu, J (Xu, Jia);Kuang, XH (Kuang, Xiangyu);Li, SB (Li, Shibao); Li, X (Li, Xiang); Zhao, X* (Zhao, Xin); Chen, DY* (Chen, Dongyan); Feng, XZ* (Feng, Xizeng). Biological impacts of glyphosate on morphology, embryo biomechanics and larval behavior in zebrafish (Danio rerio). CHEMOSPHERE, 2017, 181: 270-280. 4. Li, X(Li, Xiang);Guo, JYGuo, JY (Guo, Jia-Yu);Li, X (Li, Xu); Zhou, HJ (Zhou Hai-Jun); Zhang,SH (Zhang Shu-Hui); Liu XD (Liu, Xiao-Dong); Chen, DY* (Chen, Dong-yan); Fang, YC*(Fang Yong-Chun); Feng, XZ* (Feng, Xi-Zeng). Behavioural effect of low-dose BPA on male zebrafish: Tuning of male mating competition and female mating preference during courtship process. CHEMOSPHERE, 2017, 169, 40-52. 5. Li, X (Li, Xiang); Zhang, Y (Zhang, Yuan); Li, X (Li, Xu); Feng, DF (Feng, Dao-Fu);Zhang,SH (Zhang Shu-Hui); Zhao, X (Zhao, Xin); Chen, DY* (Chen, Dong-Yan); Zhang, ZX* (Zhang, Zhi-Xiang); Feng, XZ* (Feng, Xi-Zeng). Comparative analysis of biological effect of corannulene and graphene on developmental and sleep/wake profile ofzebrafish larvae. ACTA BIOMATERIALIA, 2017, 55, 271-282. 6. Jia, ZZ (Jia, Zhenzhen); Yang, C (Yang, Cui); Jiao, JJ (Jiao,Jiajia); Li, XY (Li, Xinyu); Zhu, DS (Zhu, Da-shuai); Yang, YC (Yang, Yongchao); Yang, JY (Yang, Jingyi); Che, YZ (Che, Yongzhe); Lu, Y* (Lu, Yun); Feng, XZ* (Feng, Xizeng). Rhein and PDMS functionalized C/C composites as prostheticimplants for bone repair application. BIOMEDICAL MATERIALS, 2017, 12, 045004. 7. Jia, ZZ (Jia, Zhenzhen); Yang, C (Yang, Cui);Jiao, JJ (Jiao,Jiajia);Li, XY (Li, Xinyu); Yang, YC (Yang, Yongchao); Yang, JY (Yang, Jingyi); Geng, XJ (Geng, Xingjie); Lu, Y* (Lu, Yun); Feng, XZ* (Feng, Xizeng). In vitro and in vivo investigation of the effects of polydimethylsiloxane and paeonol modification on the biocompatibility of carbon/carbon composites. BIOMEDICAL PHYSICS & ENGINEERING EXPRESS, 2017, 4(1), 015010. 1. Jiao, JJ (Jiao,Jia-Jia); Sun,LL (Sun,Li-Li); Guo, ZY (Guo,Zai-Yu); Hou, S (Hou, Sen);Robert Holyst*; Lu, Y*(Lu, Yun) ; Feng, XZ* (Feng, Xi-Zeng).Antibacterial and anticancer PDMS surface for mammalian cell growth using the Chinese herb extract paeonol(4-methoxy-2- hydroxyacetophenone).SCIENTIFIC REPORTS. 2016. 6:38973. 2. Han, GM (Han, Gui-Mei); Jia, ZZ (Jia, Zhen-Zhen); Zhu, YJ (Zhu, Yan-Jun); Jiao,JJ (Jiao, Jia-Jia); Kong, DM* (Kong, De-Ming); Feng, XZ* (Feng, Xi-Zeng).Biostable L-DNA-Templated Aptamer-Silver Nanoclusters for Cell-Type-Specific Imaging at Physiological Temperature. ANALYTICAL CHEMISTRY.2016. 88(22),10800-10804. 3. Li, X (Li, Xiang);Li, X (Li, Xu); Chen, D (Chen, Di);Guo, JL (Guo, Jia-Liang); Feng, DF (Feng, Dao-Fu); Sun, MZ (Sun, Ming-Zhu); Lu, Y*(Lu, Yun); Chen, DY* (Chen, Dong-Yan); Zhao, X* (Zhao, Xin); Feng, XZ* (Feng, Xi-Zeng).Evaluating the biological impact of polyhydroxyalkanoates (PHAs) on developmental and exploratory profile of zebrafish larvae. RSC ADVANCES. 2016. 6, 37018–37030. 4. Li, X (Li, Xu);Gao AA (Gao, Ai-Ai); Wang, YN (Wang, Ya-Nan); Chen, M (Chen, Man); Peng, J (Peng, Jun); Yan, HY (Yan, Hua-Ying); Zhao, X (Zhao, Xin); Feng, XZ* (Feng, Xi-Zeng); Chen, DY* (Chen, Dong-Yan).Alcohol exposure leads to unrecoverable cardiovascular defects along with edema and motor function changes in developing zebrafish larvae. BIOLOGY OPEN. 2016. 5(8),1128-1133.