个人简历

教育经历 2005.9-2009.6 西南交通大学 生物信息学专业，学士 2009.9-2016.1 中科院上海生化细胞所 发育生物学专业，博士 工作经历 2016.5-至今 南开大学生命科学学院

研究领域

""干细胞与染色质高级结构""""

近期论文

1. Jun Chen*, Shengbao Suo*, Patrick Pl Tam, Jingdong Jacky Han#, Guangdun Peng#, Naihe Jing#.Spatial transcriptomic analysis of cryosectioned tissue samples with Geo-seq，Nature Protocols, (2017) 12(3), 12(3), 566~580 (*, Co-first author) 2. Guangdun Peng*, Shengbao Suo*, Jun Chen*, Weiyang Chen, Chang Liu, Fang Yu, Ran Wang, Shirui Chen, Na Sun, Patrick P.L. Tam, Jing-Dong Jackie Han#, Naihe Jing#. Spatial transcriptome for the molecular annotation of lineage fate and cell identity in mid-gastrua mouse embryo. Developmental Cell (2016) 36(6),681-689. (*, Co-first author) 3. Xianfa Yang*, Boqiang Hu*, Yu Hou*, Yunbo Qiao#*, Ran Wang, Yingying Chen, Yun Qian, Su Feng, Jun Chen, Chang Liu, Guangdun Peng, Fuchou Tang#, Naihe Jing#. Silencing of developmental genes by H3K27me3 and DNA methylation reflects the discrepant plasticity of embryonic and extraembryonic lineages. Cell Research. (2018), doi:10.1038/s41422-018-0010-1 4. Su Feng*, Can Xing*, Tingyu Shen, Yunbo Qiao, Ran Wang, Jun Chen, Jiaoyang Liao, Zhuo Lu, Xiong Yang, Saber Abd-Allah, Jinsong Li, Naihe Jing, and Ke Tang Abnormal Paraventricular Nucleus of Hypothalamus and Growth Retardation Associated with Loss of Nuclear Receptor Gene COUP-TFII. Scientific Reports. (2017) dio:10.1038/s41598-017-05682-6 5. Xiongjun Wang*, Yunbo Qiao*, Minzhe M Xiao*, Lingbo Wang, Jun Chen, Wenjian Lv, Li Xu, Yan Li, Yumei Wang, Ming-Dian Tan, Chao Huang, Jinsong Li, Ting C Zhao, Zhaoyuan Hou#, Naihe Jing#, Y Eugene Chin#，Opposing Roles of Acetylation and Phosphorylation in LIFR-Dependent Self-Renewal Growth Signaling in Mouse Embryonic Stem Cells.，Cell Reports, (2017) 18(4), 933~946 6. Lu Song, Jun Chen, Guangdun Peng, Ke Tang, Naihe Jing. Dynamic Heterogeneity of Brachyury in Mouse Epiblast Stem Cells Mediates Distinct Response to Extrinsic Bone Morphogenetic Protein (BMP) Signaling. The Journal of Biological Chemistry (2016) 291(29), 15212~15225 7. Lingyu Li, Lu Song, Chang Liu, Jun Chen, Guangdun Peng, Ran Wang, Pingyu Liu, Ke Tang, Janet Rossant, Naihe Jing. Ectodermal progenitors derived from epiblast stem cells by inhibition of Nodal signaling. Journal of Molecular Cell Biology (2015) 7 (5): 455~465 8. Pingyu Liu, Xiaoyang Dou, Chang Liu, Lingbo Wang, Can Xing, Guangdun Peng, Jun Chen, Fang Yu, Yunbo Qiao, Lu Song, Yuxuan Wu, Chunmei Yue, Jinsong Li, Jing-Dong Han, Ke Tang, and Naihe Jing.Histone deacetylation promotes mouse neural induction by restricting Nodal-dependent mesendoderm fateNature Communications. (2015) doi:10.1038/ncomms7830. 9. Lu Song*, Na Sun*, Guangdun Peng, Jun Chen, Jing-Dong Jackie Han, Naihe Jing. Genome-wide ChIP-seq and RNA-seq analyses of Pou3f1 during mouse pluripotent stem cell neural fate commitment. Genome Data, (2015), 5：375~377 10. Qingqing Zhu Lu Song, Guangdun Peng, Na Sun,Jun Chen, Ting Zhang, Nengyin Sheng, Wei Tang, Cheng Qian, Yunbo Qiao, Ke Tang, Jing-Dong J Han, Jinsong Li, Naihe Jing. The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways. eLife (2014)10.7554/eLife.02224. 11. Yunbo Qiao, Yue Zhu, Nengyin Sheng, Jun Chen, Ran Tao, Qingqing Zhu, Ting Zhang, Cheng Qian, Naihe Jing.AP2γ regulates neural and epidermal development downstream of the BMP pathway at early stages of ectodermal patterning. Cell Research (2012) 22(11), 1546~1561. 12. Chengyang Huang, Jun Chen, Ting Zhang, Qingqing Zhu, Yang Xiang, Charlie Degui Chen, Naihe Jing. The dual histone demethylase KDM7A promotes neural induction in early chick embryos. Developmental Dynamics (2010) 239, 3350~3357.