个人简历
教育经历 1994.9，美国印第安纳大学医学院，生化与分子生物学系，博士学位 工作经历 2002/11-今 教授，博导，南开大学生命科学学院,天津 2001/4-2002/9 助研教授(Research Assistant professor) 美国杜克大学药理和肿瘤分子生物学系 1998/1-2001/3 助理研究员(Research Associate) 美国杜克大学药理和肿瘤分子生物学系 1995/4-1997/12 资深研究科学家(Sr Research Scientist) 美国Centeon制药公司(Aventis前身) 1994/10-1995/3 博士后(Postdoctoral Research Fellow) 美国华盛顿大学药理学系
研究领域
1）疱疹病毒与宿主细胞相互作用的分子机制； 2）淋巴T细胞激活的信号转导与分子机制；3）基于HSV的溶瘤病毒的改造与开发。
近期论文
Wang RK, Wang JY， Zhang NC, Wan YJ a, Liu YH, Zhang LM, Pan S., Zhang CZ, Zhang HK*, Cao Y* The interaction between Vav1 and EBNA1 promotes survival of Burkitt's lymphoma cells by down-regulating the expression of Bim. Biochem.Biophys. Research Comm.2019,511:787e793 Pan S., Liu X., Ma Y., Cao Y*., and He B*. Herpes Simplex Virus 1 gamma134.5 Protein Inhibits STING Activation That Restricts Viral Replication. 2018, J Virol 92(20)e01015-18. Wu SF, Pan S, Zhang LM, Baines J, Roller R, Ames J, Yang MM, Wang JY， Chen D, Liu YH, Zhang CZ, Cao Y*, He B*. Herpes Simplex Virus 1 Induces Phosphorylation and Reorganization of lamin A/C Through the γ134.5 Protein That Facilitates Nuclear Egress.J. Virol. November 2016; 90:22 9 10414-10422 Yang Y. Wu S., Wang Y, Pan S, Zhang LM, Lan B., Liu YH.,Leng QL., Zhang C, He B., Cao Y*.The Us3 Protein of Herpes Simplex Virus 1 Inhibits T Cell Signaling by Confining LAT Activation via TRAF6 Protein. J. Biol. Chem. 2015,Jun 19;290(25):15670-8. Wang Y, Yang Y, Wu S, Pan S, Zhou C, Ma Y, Ru Y, Dong S, He B, Zhang C, Cao Y*. P32 Is a Novel Target for ICP34.5 of Herpes Simplex Virus Type 1, and Facilitates Viral Nuclear Egress.J Biol Chem. 2014 Dec 26;289(52):35795-805. Du MJ, Chen XD, Zhou XL, Wan YJ, Lan B, Zhang CZ, Cao Y*.Estrogen induces Vav1 expression in human breast cancer cells. PLoS One. 2014 Jun 6;9(6):e99052. Wan YJ, Yang Y, Leng QL, Lan B, Jia HY, Liu YH, Zhang CZ,Cao Y*.Vav1 increases Bcl-2 expression by selective activation of Rac2-Akt in Leukemia T cells.Cell Signal. 2014 Oct;26(10):2202-9. YS Wang, Hao He, S Li, B Lan, Y Cao, M Hu, C Wang. All-optical regulation of gene expression in targeted cells. Scientific Reports, 4, 5346 (2014) Li SY, Du MJ, Wan YJ, Lan B, Liu YH, Yang Y, Zhang CZ, Cao Y*.The N-terminal 20-Amino Acid Region of Guanine Nucleotide Exchange Factor Vav1 Plays a Distinguished Role in T Cell Receptor-mediated Calcium Signaling. J Biol Chem. 2013 Feb 8;288(6):3777-85.
