个人简历

博士毕业于南京医科大学，毕业论文入选为江苏省优秀博士学位论文。同年加入中国药科大学天然药物活性组分与药效国家重点实验室工作，先后担任助理研究员和特聘副研究员、硕士生导师。2019年通过高层次人才引进加入南京师范大学工作。作为课题负责人，主持了国家自然科学基金面上项目1项、国家自然科学青年基金1项、以及江苏省自然科学青年基金1项等项目。2018年入选为江苏省“六大人才高峰”高层次人才。近年来，在国际知名期刊Nucleic Acids Res、Hypertension、Oncogene、Biochimica et Biophysica Acta等发表SCI论文10余篇。

研究领域

表观遗传调控在心血管、肿瘤等疾病中的作用以及新靶点发现

近期论文

1. Yuyu Yang#, Dewei Chen#, Zhibin Yuan#, Fei Fang, Xian Cheng, Jun Xia, Mingming Fang, Yong Xu*, Yuqi Gao*. Megakaryocytic leukemia 1 (MKL1) ties the epigenetic machinery to hypoxia-induced transactivation of endothelin-1. Nucleic Acids Research, 2013; 41(12): 6005-6017. [SCI IF：8.808] Top期刊
2. Yuyu Yang, Xian Cheng, Wenfang Tian, Bisheng Zhou, Xiaoyan Wu, Huihui Xu, Fei Fang, Mingming Fang, Yong Xu*. MRTF-A steers an epigenetic complex to activate endothelin-induced pro-inflammatory transcription in vascular smooth muscle cells. Nucleic Acids Research, 2014; 42(16): 10460-10472. [SCI IF:9.112] Top期刊
3. Xian Cheng#, Yuyu Yang#, Zhiwen Fan, Liming Yu, Hui Bai, Bisheng Zhou, Xiaoyan Wu, Huihui Xu, Mingming Fang*, Aiguo Shen, Qi Chen ,Yong Xu*. MKL1 potentiates lung cancer cell migration and invasion by epigenetically activating MMP9 transcription. Oncogene, 2015; 34(44):5570-81. [SCI IF:7.932] Top期刊
4. Dewei Chen#, Yuyu Yang#, Xian Cheng, Fei Fang, Gang Xu, Zhibin Yuan, Jun Xia, Hui Kong,Weiping Xie, Hong Wang, Mingming Fang, Yuqi Gao*, Yong Xu*. Megakaryocytic Leukemia 1 Directs a Histone H3 Lysine 4 Methyltransferase Complex to Regulate Hypoxic Pulmonary Hypertension. Hypertension, 2015; 65(4): 821-33. [SCI IF:6.294]
5. Yuyu Yang#, Xueyan Li#, Liying Peng, Lin An, Ningyuan Sun, Xuewen Hu, Ping Zhou, Yong Xu, Ping Li*, Jun Chen*. Tanshindiol C inhibits oxidized low-density lipoprotein induced macrophage foam cell formation via a peroxiredoxin 1 dependent pathway. Biochimica et Biophysica Acta-Molecular Basis of Disease. 2018; 1864(3):882-890. [SCI IF: 4.328] Top期刊