个人简历

2011年以来，以通讯作者发表21篇SCI学术榜论著，包括11篇TOP论文。单篇最高IF 8.097（发表时5.93）。1 篇ESI热点与高被引论文，1篇ESI高被引论文。获得8项与新药有关的发明专利，其中3 项国际专利公开PCT。参与2 项新药研发被批准临床研究

研究领域

以细胞膜上p-糖蛋白（p-gp）为切入点，围绕它的表达、细胞膜定位、线粒体功能、p-gp-ATP酶的相互作用，对抗癌药物与环境内分泌干扰物(EDCs)的吸收、分布与毒性进行探讨。以此为基础，主要在两个方向进行研究。在药学领域，研究方向为逆转癌症多药耐药（Multidrug resistance, MDR）的新型纳米递药系统（Nano-drug delivery system, NDDS）的生物效应与机理研究。在抗癌药物的靶向与共递药、细胞核递药以及MDR细胞内精准药物释放与逆转MDR方面进行探讨。在毒理学领域，对食品乳化剂与肠道微生物互作影响EDCs的吸收、毒性靶器官分布与毒效机理方面进行探讨

近期论文

Shan-Shan Qi, Ling-Yuan Guo, Shu-Zhen Yan, Robert J. Lee, Shu-Qin Yu*, Shuang-Lin Chen*.Hypocrellin A-based photodynamic action induces apoptosis in A549 cells through ROS-mediated mitochondrial signaling pathway. ActaPharmaceuticaSinicaBdoi.org/10.1016/j.apsb.2018.12.004【SCI, TOP, IF=6.014】
Jia-Hui Sun, Chong Ye, En-He Bai, Ling-Ling Zhang, Shao-JieHuo, Hao-Han Yu, Su-Yun Xiang*, Shu-Qin Yu*. Co-delivery nanoparticles of doxorubicin and chloroquine for improving the anti-cancer effect in vitro. Nanotechnology 2019;30(8):85101 【SCI, TOP, IF=3.404】
Hai-TaoGao, RunXu, Wei-XinCao, Qian-NanDi, Rui-XianLi,LingengLu, QianXu, Shu-Qin Yu*.Combined effects of simultaneous exposure to six phthalates and emulsifier glycerol monosterate on male reproductive system in rats. Toxicology and Applied Pharmacology 341:2018, 87–97【SCI, IF=3.616】
Shan-Shan Qi, Jia-Hui Sun, Hao-Han Yu, Shu-Qin Yu*. Co-delivery nanoparticles of anti-cancer drugs forimproving chemotherapy efficacy.Drug Delivery. 2017; 24(1)：1909-1926【SCI, TOP, IF=6.40】
Xi Lin, Shun-Zhen Yan, Shan-Shan Qi, QiaoXu, Shuang-Shuang Han, Ling-Yuan Gu, Ning Zhao, Shuang-Lin Chen*,Shu-Qin Yu*. Transferrin-Modified Nanoparticles for Photodynamic Therapy Enhance the Antitumor Efficacy of Hypocrellin A. Frontiers in Pharmacology.2017;8:0815【SCI,IF=4.40】
Ling-Yuan Guo, Shu-Zhen Yan, Qiang Li, QiaoXu, Xi Lin, Shan-Shan Qi, Shu-Qin Yu*, Shuang-Lin Chen*. Poly(lactic-co-glycolic) acid nanoparticles improve oral bioavailability of hypocrellin A in rat. RSC Advances.2017; 7: 42073-42082 【SCI, IF=3.15】
Dan-Dan Zhang, Yan-Yan Kong, Jia-Hui Sun, Shao-JieHuo, Min Zhou, Yi-Ling Gui, Shu-Qin Yu*, QianXu*. Co-delivery nanoparticles with characteristics of intracellular precision release drugs for overcoming multidrug resistance. International Journal of Nanomedicine.2017;12:20181-2108 【SCI, TOP, IF=4.30】
Hai-Tao Gao, Run Xu, Wei-Xin Cao, Liang-Liang Qian, Min Wang, Lingeng Lu, QianXu*,Shu-Qin Yu*, Effects of six priority controlled phthalate esters with long-term low-dose integrated exposure on male reproductive toxicity in rats. Food and Chemical Toxicology. 2017;101:94-104【SCI, TOP, IF=3.584】【ESI热点论文/ ESI高被引论文】
Ying-Ying Wang, Dan-Dan Zhang, Yan-Yan Kong, Luan-Luan Shao, Fen-Yi Zhang, Yu Gao, Xu Mu, Jie Wang, Hao-Fan Li, Shu-Qin Yu*, QianXu*. CS/PAA@TPGS/PLGA nanoparticles with intracellular pH-sensitivesequential release for delivering drug to the nucleus of MDR cells. Colloids and Surfaces B: Biointerfaces. 2016; 145:716-727【SCI, IF=4.12】
Wang Dong-Fang, Rong Wen-Ting, Lu Yu, HouJie, Qi Shan-Shan, Xiao Qing, Zhang Jue, You Jin,Shu-QinYu*, XuQian*. TPGS2k/PLGA nanoparticles for overcoming multidrug resistance by interfering mitochondria of human alveolar adenocarcinoma cells. ACS Applied Materials & Interfaces.2015; 7(7): 3888-3901 【SCI, TOP, IF=5.93】
Lu Yu, Wang Ying-Ying, Yang Nan, Zhang Dan, Zhang Feng-Yi, GaoHai-Tao, Rong Wen-Ting, Shu-Qin Yu*, XuQian. Food emulsifier polysorbate 80 increases intestinal absorption of di-(2-ethylhexyl) phthalate in rats.Toxicological Sciences.2014: 139 (2): 317-327【SCI, IF=4.50】
Rong Wen-Ting, Lu Ya-Peng, Tao Qing, Guo Miao, Lu Yu, RenYong , Shu-Qin Yu*.Hydroxypropyl-sulfobutyl-β-cyclodextrin improves the oral bioavailability of edaravone by modulating drug efflux pump of enterocytes. Journal of Pharmaceutical Sciences. 2014; 103(2): 730-742 【SCI, IF=3.3】
Qi Shan-Shan, Lin Xi, Zhang Miao-Miao, Yan Shu-Zhen, Shu-Qin Yu*, Chen Shuang-Lin*. Preparation and evaluation of hypocrellin A loaded poly(lactic-co-glycolic acid) nanoparticles for photodynamic therapy. RSC Advances.2014; 4 (75): 40085-40094 【SCI, IF=3.8】
Ya-Peng Lu, Si-Yuan Liu, Yu Zhao, Li Zhu*, Shu-Qin Yu*. Complexation of Z-ligustilide with hydroxypropyl-b-cyclodextrin to improve stability and oral bioavailability. Acta Pharmaceutica.2014; 64:211-222 【SCI, IF=1.0】
Guo Miao, Rong Wen-Ting, HouJie, Wang Dong-Fang, Lu Yu, Wang Ying,Shu-Qin Yu*, XuQian*. Mechanisms on chitosan-coated poly (lactic-co-glycolic acid) nanoparticles for improving oral absorption of 7-ethyl-10-hydroxycamptothecin. Nanotechnology. 2013; 24: 245101 (15pp) 【SCI, TOP, IF=3.90】
Wang Ying, Guo Miao, Lu Yu, Ding Li-Ying, Ron Wen-Ting, Liu Ya-Qing, Song Fei-Fei, Shu-Qin Yu*. Alpha-tocopheryl polyethylene glycol succinate-emulsified poly(lactic-co-glycolic acid) nanoparticles for reversal of multidrug resistance in vitro. Nanotechnology.2012; 23:495103 (14pp) 【SCI, TOP, IF=3.90】
Chen Cheng, Xie Xiao-Xia, Zhou Qian, Zhang Feng-Yi, Wang Qiao-Lin, Liu Ya-Qing, Zou Yi-Na, Tao Qing, JiXue-Mei, Shu-Qin Yu*. EGF-functionalized single-walled carbon nanotubes for targeting delivery of etoposide. Nanotechnology. 2012; 23: 045104 (12pp) 【SCI, TOP, IF=3.90】
XuQian, Wang Min, Shu-Qin Yu*, Tao Qing, Tang Meng*. Trace analysis of diethylstilbestrol, dienestrol and hexestrol in environmental water by Nylon 6 nanofibers mat-based solid-phase extraction coupled with liquid chromatography-mass spectrometry. Analyst.2011; 136 (23): 5030-5037 【SCI, IF=3.90】
Huang Xing-Xing, Zhou Cheng-Liang, Wang Hui, Chen Cheng, Shu-Qin Yu*, XuQian, Zhu Yin-Yan, Ren Yong. Pharmacokinetics, efficacy, and safety evaluation of docetaxel/hydroxypropyl-sulfobutyl-beta-cyclodextrin inclusion complex. AAPS PharmSciTech. 2011; 12(2): 665-672 【SCI, IF=1.24】
Xie Xiao-Xia, Tao Qing, Zou Yi-Na, Zhang Feng-Yi, Guo Miao, Wang Ying, Wang Hui, Zhou Qian, Shu-Qin Yu*. PLGA nanoparticles improve the oral bioavailability of curcumin in rats: characterizations and mechanisms.Journal of Agricultural and Food Chemistry. 2011; 59 (17): 9280-9289 【SCI, TOP, IF=2.93】【ESI高被引论文】
Wang Hui, Xie Xiao-Xia, Zhang Feng-Yi, Zhou Qian, Tao Qing, Zou Yi-Na, Chen Cheng, Shu-Qin Yu*. Evaluation of cholesterol depletion as a marker of nephrotoxicity in vitro for novel β-cyclodextrin derivatives. Food and Chemical Toxicology.2011; 49(6): 1387-1393【SCI, TOP, IF=2.80】