个人简历

教育与工作经历
教育经历：
1995年，获得南京农业大学学士学位
1998年，获得南京农业大学硕士学位
2003年，获得南京农业大学博士学位
工作经历：
1998年至今，南京农业大学动物科技学院任教
海外学习经历：
2001年，加拿大圭尔夫大学
2004年，德国莱布尼兹家畜研究所
2008年，美国华盛顿州立大学
2016年，英国卡迪夫大学

奖励及荣誉
2010年入选江苏省“青蓝工程”优秀青年骨干教师培养对象，以及南京农业大学“133重点人才工程”优秀骨干教师培养计划。

承担科研项目
1.民猪米色脂肪细胞转化机制与特征研究，国家自然科学基金联合基金项目子任务，52万，2021-2024年；
2.MSTN/miR-124a-2/GR通路介导猪肌肉组织特异性调控肌内脂肪细胞分化的机制研究，国家自然科学基金面上项目，59万，2019-2022年；
3.猪优质肉种质资源保护、分子基础挖掘与创新，国家科技支撑计划
课题，482万，2015-2019年；
4.P160基因家族组织特异性调控猪肌内脂肪沉积的分子机制研究，国家自然科学基金面上项目，80万，2013-2016年；
5.优质高繁白羽肉鹅配套的培育与推广，江苏省农业重大新品种创制项目，24万，2017-2021年；
6.鹅产蛋性能分子选育技术研究及应用于扬州鹅高产蛋品系选育研究，江苏省农业科技自主创新资金，30万，2014-2017年；
7.高产优质转基因奶羊新品种培育，农业部转基因生物新品种培育重大专项，50万，2011-2012年；
8.基于全基因组关联分析挖掘猪肌内脂肪含量相关基因的研究，中央高校基本科研业务费专项资金项目，40万，2011-2014年；
9.猪肌内前体脂肪细胞分化特异性调控基因的分离与功能研究，国家自然科学基金青年科学基金项目，20万，2009-2011年。

研究领域

动物分子遗传育种;
畜禽重要经济性状形成的分⼦子机制;
畜禽分⼦子育种技术。"动物遗传育种与繁殖"

近期论文

1. Wang Q, Wang Q, Melak S, Lin X, Wei W, Zhang L, Chen J. A novel c.-652C>T mutation in UCHL1 gene is associated with the growth performance in Yangzhou goose. Poult Sci. 2021 Jul;100(7):101089.
2. Melak S, Wang Q, Tian Y, Wei W, Zhang L, Elbeltagy A, Chen J. Identification and Validation of Marketing Weight-Related SNP Markers Using SLAF Sequencing in Male Yangzhou Geese. Genes. 2021 Aug 3;12(8):1203
3. Lin Weimin, Tang Yonghang, Zhao Yuelei, Zhao Jindi, Zhang Lifan, Wei Wei, Chen Jie*, MiR-144-3p Targets FoxO1 to Reduce Its Regulation of Adiponectin and Promote Adipogenesis, Frontiers in Genetics, 2020, 11:603144.
4. Weimin Lin，Hongcheng Liu，Yonghang Tang，Yuchen Wei，Jie Chen*. The development and controversy of competitive endogenous RNA hypothesis in non-coding genes. Molecular and Cellular Biochemistry, 2020, DOI: 10.1007/s11010-020-03889-2.
5. Hongcheng Liu#, Wei Wei#, Weimin Lin, Wensai Yu, Wu Luo, Yingfang Niu, Lifan Zhang, Jie Chen*. miR-32-5p Regulates Lipid Accumulation in Intramuscular Fat of Erhualian Pigs by Suppressing KLF3, Lipids, 2020, 10(1): 10.1002/lipd.12294.
6. Kaiqing Liu#, Wensai Yu#, Wei Wei, Xinbao Zhang, Ye Tian, Melak Sherif, Xin Liu, Chao Dong, Wangjun Wu, Lifan Zhang and Jie Chen*, Melatonin reduces intramuscular fat deposition by promoting lipolysis and increasing mitochondrial function, Journal of Lipid Research, 2019, 60(4):767-782.
7. Kaiqing Liu, Xinbao Zhang, Wei Wei, Xin Liu, Ye Tian, Haiyin Han, Lifan Zhang, Wangjun Wu and Jie Chen*, Myostatin/SMAD4 signaling-mediated regulation of miR-124-3p represses glucocorticoid receptor expression and inhibits adipocyte differentiation, American Journal of Physiology-Endocrinology and Metabolism,2019, 316(4):E635-E645.
8. Mengyuan Xia, Wei Wei, Zaohang Jiang, Dandan He, Zhen Li, Shigang Yu, Qiushi Wang, Honglin Liu and Jie Chen*, A Functional Mutation in KIAA1462 Promoter Decreases Glucocorticoid Receptor Affinity and Affects Egg-Laying Performance in Yangzhou Geese, International Journal of Molecular Sciences, 2018, 19,1531.
9. Dandan He, Zaohang Jiang, Ye Tian, Haiyin Han, Mengyuan Xia, Wei Wei, Lifan Zhang, Jie Chen*, Genetic variants in IL 15 promoter affect transcription activity and intramuscular fat deposition in longissimus dorsi muscle of pigs, Animal Genetics, 2018, 49(1): 19-28.
10. Haiyin Han, Shuhua Gu, Weiwei Chu, Wenxing Sun, Wei Wei, Xiaoyong Dang, Ye Tian, Kaiqing Liu, Jie Chen*, miR-17-5p Regulates Differential Expression of NCOA3 in Pig Intramuscular and Subcutaneous Adipose Tissue, Lipids, 2017, 52(11): 939-949.
11. Wei Wei#, Wenxing Sun#, Haiyin Han, Weiwei Chu, Lifan Zhang, Jie Chen*, miR-130a regulates differential lipid accumulation between intramuscular and subcutaneous adipose tissues of pigs via suppressing PPARG expression, Gene, 2017, 636:23-29.
12. Haiyin Han, Wei Wei, Weiwei Chu, Kaiqing Liu, Ye Tian, Zaohang Jiang, and Jie Chen*, Muscle Conditional Medium Reduces Intramuscular Adipocyte Differentiation and Lipid Accumulation through Regulating Insulin Signaling, International Journal of Molecular Sciences, 2017, 18(8): 1799.
13. Weiwei Chu#, Wei Wei#, Haiyin Han, Ying Gao, Kaiqing Liu, Ye Tian, Zaohang Jiang, Lifan Zhang, Jie Chen*, Muscle-specific downregulation of GR levels inhibits adipogenesis in porcine intramuscular adipocyte tissue, Scientific Reports, 2017, 7(1):510.
14. S. Yu, M. Xia, M. A. Alsiddig, H. Liu, W. Wei*, J. Chen*, Molecular cloning, alternative splicing and mRNA expression analysis of MAGI1 and its correlation with laying performance in geese, British Poultry Science, 2017, 58(2):158-165.
15. Wenxing Sun，MV Dodson，Zaohang Jiang，Shigang Yu，Weiwei Chu，Jie Chen*. Myostatin inhibits porcine intramuscular preadipocyte differentiation in vitro. Domestic Animal Endocrinology, 2016,55:25-31
16. Weiwei Chu, Wei Wei, Shigang Yu, Haiyin Han, Xiaoli Shi, Wenxing Sun, Ying Gao, Lifan Zhang, Jie Chen*, C2C12 myotubes inhibit the proliferation and differentiation of 3T3-L1 preadipocytes by reducing the expression of glucocorticoid receptor gene, Biochemical and Biophysical Research Communications, 2016, 472(1):68-74.
17. Shigang Yu, Wei Wei, Mengyuan Xia, Zaohang Jiang, Dandan He, Zhen Li, Haiyin Han, Weiwei Chu, HongLin Liu, Jie Chen*, Molecular characterization, alternative splicing and expression analysis of ACSF2 and its correlation with egg-laying performance in geese, Animal Genetics, 2016, 47(4):451-462.
18. Haoxin Yang, Jiawen He, Wei Wei, Weiwei Chu, Shigang Yu, Ye Tian, Fengyi Peng, Hongcheng Liu, Zengkai Zhang, Jie Chen*, The c.-360 T>C mutation affects PGAM2 transcription activity and is linked with the water holding capacity of the longissimus lumborum muscle in pigs, Meat Science, 2016, 122:139-144.
19. ShiGang Yu, WeiWei Chu, LiFan Zhang, HouMing Han, RongXue Zhao, Wei Wu, JiangNing Zhu, Michael V. Dodson, Wei Wei, HongLin Liu, Jie Chen*, Identification of Laying-Related SNP Markers in Geese Using RAD Sequencing, PLoS One, 2015, 10(7): e0131572.
20. Dang XY, Chu WW, Shi HC, Yu SG, Han HY, Gu SH, Chen J*. Genetic variants in ABCA1 promoter affect transcription activity and plasma HDL level in pigs. Cellular and Molecular Life Sciences. Gene, 555(2): 414-420.
中国畜牧兽医学会动物遗传育种学分会 理事
中国畜牧兽医学会动物遗传标记学分会 理事