陈兴祥
近期热点
资料介绍
个人简历
现任动物医学院临床兽医系副系主任,国家宠物产业科技创新联盟常务理事,中国畜牧兽医学会兽医内科与临床诊疗学分会常务理事,主要承担《兽医内科学》、《兽医临床诊断学》、《动物营养代谢病》、《兽医临床实验检验技术》等课程的教学工作,从事动物营养代谢病与中毒病、兽医临床病理学与分子诊断学、小动物疾病等方面的科研工作。指导研究生 16 名,其中外国留学生 2 名。科研工作经历:2021 – 现在 南京农业大学动物医学院,教授。2015 – 2020 南京农业大学动物医学院,副教授,其中 2016/3–2017/3 英国纽卡斯尔大学访问学者。2012 – 2014 南京农业大学动物医学院,讲师,其中 2013/7–2013/10 英国纽卡斯尔大学访问学者。2002 – 2009 江苏省农业科学院,兽医研究所。受教育经历:2009/09 – 2012/06 南京农业大学,动物医学院,博士。1999/09 – 2002/06 南京农业大学,动物医学院,硕士。1995/09 – 1999/06 南京农业大学,动物医学院,学士。科研项目:1) 新瑞鹏高校青年教师小动物临床科研基金项目,RPJJ2021029,犬源产维生素 B12 乳酸菌在犬慢性肠炎中的初步应用,2022/01-2022/12,主持。2 / 52) 国家自然科学基金面上项目,31972745,呕吐毒素、伏马毒素 B1 单一及联合暴露引起猪肠道炎症的细胞焦亡机制研究,2020/01 – 2023/12,主持。3) 国家自然科学基金中英国际合作项目,31811530300,细胞凋亡在氧化应激诱导自噬促进 PCV2 持续感染增殖中的作用研究,2018/04-2020/03,主持。4) 中央高校基本科研业务费重点项目,KYZ2018051,卓越兽医师研究生课程的建设与优化创新,2018/07-2021/06,主持。5) 国家重点研发计划(子课题),2017YFD0501001,富硒锌伴侣动物复合菌制剂研发与应用, 2017/07-2021/06,主持。6) 国家重点研发计划(子课题),2016YFD0501203,牛羊微量元素与维生素代谢病及电解质失衡综合防控技术集成与示范研究,2016/07-2021/06,主持。7) 国家自然科学基金面上项目,31472252,氧化应激影响 PCV2 感染复制的自噬机制及其营养调控研究,2015/01-2018/12,主持。8) 中央高校基本科研业务费重点项目,Y0201500198,赭曲霉毒素 A 促进PCV2 复制的自噬机制,2015/01-2017/12,主持。9) 教育部博士点基金项目,20130097120025,细胞自噬在氧化应激促进PCV2 感染中的作用研究,2014/01-2016/12,主持。10) 江苏省自然科学基金面上项目,BK20131323,硒蛋氨酸影响 PCV2 感染的自噬机制,2013/07-2016/06,主持。荣誉奖项:1) 黄克和,刘宗平,陈兴祥,甘芳,潘翠玲,任志华,秦顺义.几种畜禽非传染性群发疾病的防控关键技术研究与应用,江苏省科学技术奖三等奖,江苏省人民政府,2020。2) 陈兴祥.江苏省优秀博士论文(指导老师:黄克和),江苏省学位委员会,2013。3) 黄克和,陆克文,张克春,潘翠玲,陈兴祥,秦顺义.新型多功能生物饲料添加剂的创制与应用,高等学校科学研究优秀成果奖技术发明奖二等奖,教育部, 2012。国家发明专利:1) 陈兴祥,李本睿,牟佳欣,葛雷,后丽丽,蒋帅,黄克和,潘翠玲,甘芳. 犬源产维生素 B12 乳酸菌及应用,2020.07,中国,发明专利号:ZL 3 / 5202010756524.92) 黄克和,王育林,袁征,孙嘉豪,潘翠玲,陈兴祥,甘芳. 一种犬猫泌尿系统结石成分快速定性分析试剂盒,2019.04,中国,发明专利号:ZL201920438230.43) 黄克和,刘瑾,叶耿坪,陈兴祥,刘云欢,刘永杰,甘芳. 一种抗奶牛热应激的饲料添加剂,2015.12,中国,发明专利号:ZL 201310632843.9。4) 黄克和,车超平,杨玉澜,潘翠玲,陈兴祥.一种原代鸡肝细胞的分离培养方法, 2015.5,中国,发明专利号:ZL 201310503594.3。5) 黄克和,甘芳,陈兴祥,任飞,吕晨辉,赵如茜,潘翠玲,周红,叶耿坪,石秀丽.一种抗猪热应激的富硒复合菌饲料添加剂及其应用,2013.7,中国,发明专利号:201210333510.1。6) 黄克和,任志华,蒋鲁岩,陈兴祥.草酸降解菌 NJODE1 及其应用,2013.9,中国,发明专利号:201110169374.2。研究领域
动物营养代谢病与中毒病兽医临床病理学与分子诊断学小动物疾病""近期论文
1) Mao X, Li H, Ge L, Liu S, Hou L, Yue D, Du H, Pan C, Gan F, Liu Y, HuangK, Chen X*. Selenomethionine alleviated Ochratoxin A induced pyroptosisand renal fibrotic factors expressions in MDCK cells. J Biochem Mol Toxicol.2021 Oct 21:e22933. doi: 10.1002/jbt.22933. Online ahead of print.2) Li H#, Mao X#, Liu K, Sun J, Li B, Malyar RM, Liu D, Pan C, Gan F, Liu Y,Huang K, Chen X*. Ochratoxin A induces nephrotoxicity in vitro and in vivovia pyroptosis. Arch Toxicol, 2021, 95(4):1489-1502. (毒理学 TOP 期刊)3) Malyar RM, Naseri E, Li H, Ali I, Farid RA, Liu D, Maroof K, Nasim M,Banuree SAH, Huang K, Waldron KJ, Chen X*. Hepatoprotective Effects ofSelenium-Enriched Probiotics Supplementation on Heat-Stressed Wistar RatThrough Anti-Inflammatory and Antioxidant Effects. Biol Trace Elem Res.2021, 199(9):3445-3456.4) Mao X, Fu C, Liu K, Li H, Malyar RM, Li B, Pan C, Gan F, Huang K, ChenX*. Effects of Glycerol-Producing Yeast Supplementation on ProductionPerformance, Biochemical Indexes, Subclinical Ketosis Incidence andRumen Fermentation Performance of Dairy Cows. Int J Nutr Sci. 2021; 6(1):1049.5) Liu K, Mao X, Li H, Liu D, Le G, Gan F, Pan C, Huang K, Chen X*.Regulation of taurine in OTA-induced apoptosis and autophagy. Toxicon. 4 / 52020 Jul 15;181:82-90. doi: 10.1016/j.toxicon.2020.04.097.6) Malyar RM, Li H, Liu D, Abdulrahim Y, Farid RA, Gan F, Ali W,Enayatullah H, Banuree SAH, Huang K, Chen X*. Selenium/Zinc-Enrichedprobiotics improve serum enzyme activity, antioxidant ability, inflammatoryfactors and related gene expression of Wistar rats inflated under heat stress.Life Sci. 2020 May 1;248:117464. doi: 10.1016/j.lfs.2020.117464. Epub2020 Feb 22.7) Li H, Malyar RM, Zhai N, Wang H, Liu K, Liu D, Pan C, Gan F, Huang K,Miao J, Chen X*. Zinc supplementation alleviates OTA-induced oxidativestress and apoptosis in MDCK cells by up-regulating metallothioneins. LifeSci. 2019, 234:116735.8) Mohammad Malyar R, Li H, Enayatullah H, Hou L, Ahmad Farid R, Liu D,Akhter Bhat J, Miao J, Gan F, Huang K, Chen X*. Zinc-enriched probioticsenhanced growth performance, antioxidant status, immune function, geneexpression, and morphological characteristics of Wistar rats raised under highambient temperature. 3 Biotech. 2019, 9(8):291.9) Zhai N, Liu K, Li H, Liu Z, Wang H, Korolchuk VI, Carroll B, Pan C, Gan F,Huang K, Chen X*. PCV2 replication promoted by oxidative stress isdependent on the regulation of autophagy on apoptosis. Vet Res. 2019,50(1):19. (兽医学 TOP 期刊)10) Chen X, Xu J, Liu D, Sun Y, Qian G, Xu S, Gan F, Pan C, Huang K*. Theaggravating effect of selenium deficiency on T-2 toxin-induced damage onprimary cardiomyocyte results from a reduction of protective autophagy.Chem Biol Interact. 2019, 300:27-34.11) Zhai N, Wang H, Chen Y, Li H, Viktor K, Huang K, Chen X*. Taurineattenuates OTA-promoted PCV2 replication through blockingROS-dependent autophagy via inhibiting AMPK/mTOR signaling pathway.Chem Biol Interact. 2018, 296:220-228.12) Qian Gang, Liu Dandan, Hu Junfa, Gan Fang, Hou Lili, Zhai Nianhui, ChenXingxiang*, Huang Kehe*. SeMet attenuates OTA-induced PCV2replication promotion by inhibiting autophagy by activating the AKT/mTORsignaling pathway. Vet Res, 2018, 49(1): 15. (兽医学 TOP 期刊)13) Liu Dandan, Xu Jing, Qian Gang, Hamid Mohammed, Gan Fang, ChenXingxiang*, Huang Kehe*. Selenizing astragalus polysaccharide attenuates 5 / 5PCV2 replication promotion caused by oxidative stress through autophagyinhibition via PI3K/AKT activation. Int J Biol Macromol, 2018, 108:350~359.14) Qian Gang, Liu Dandan, Hu Junfa, Gan Fang, Hou Lili, Chen Xingxiang*,Huang Kehe *, Ochratoxin A-induced autophagy in vitro and in vivopromotes porcine circovirus type 2 replication. Cell Death & Disease, 2017,8: e2909.15) Chen Xingxiang, Che Chaoping, Korolchuk Viktor, Gan Fang, Pan Cuiling,Huang Kehe*, Selenomethionine Alleviates AFB1-Induced Damage inPrimary Chicken Hepatocytes by Inhibiting CYP450 1A5 Expression viaUpregulated SelW Expression. Journal of Agricultural and Food Chemistry,2017, 65(12): 2495~2502. (农业科学 TOP 期刊)16) Zheqian Zhang, Fang Gan, Hongxia Xue, Yunhuan Liu, Da Huang, Alam ZebKhan, Xingxiang Chen*, Kehe Huang*. Nephropathy and hepatopathy inweaned piglets provoked by natural ochratoxin A and involved mechanisms.Experimental and Toxicologic Pathology, 2016, 68(4): 205~213.17) Chen Xingxiang, Shi Xiuli, Gan Fang, Huang Da, Huang Kehe*. Glutaminestarvation enhances PCV2 replication via the phosphorylation of p38 MAPK,as promoted by reducing glutathione levels . Veterinary Research, 2015,46:32. (兽医学 TOP 期刊)18) Chen Xingxiang, Ren Fei, Hesketh John, Shi Xiuli, Li Junxian, Gan Fang,Huang Kehe*. Interaction of porcine circovirus type 2 replication withintracellular redox status in vitro. Redox Rep, 2013, 18(5): 186~192.19) Chen Xingxiang, Ren Fei, Hesketh John, Shi Xiuli, Li Junxian, Gan Fang,Huang Kehe*. Selenium blocks porcine circovirus type 2 replicationpromotion induced by oxidative stress by improving GPx1 expression. FreeRadical Biology and Medicine, 2012.8.1, 53(3): 395~405.20) Chen Xingxiang, Ren Fei, Hesketh John, Shi Xiuli, Li Junxian, Gan Fang,Huang Kehe*. Reactive oxygen species regulate the replication of porcinecircovirus type 2 via NF-kappaB pathway. Virology, 2012.4.25, 426(1):66~72. 相关热点
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