个人简历

教育与工作经历
1989年9月-1993年7月，安徽师范大学，生物专业攻读本科
1993年9月-1996年7月，安徽师范大学，动物学专业攻读硕士
2002年9月-2005年7月，南京农业大学，动物遗传育种与繁殖专业攻读博士
2013年1月-2016年4月，美国佐治亚医学院，生化与分子生物学系开展博士后研究工作
1996年7月-2012年12月，在安徽师范大学任教
2016年4月至今，在南京农业大学动物科技学院任教

奖励及荣誉
南京农业大学高层次人才（2016）；省优秀青年科技创新奖（2012）；省高校优秀中青年骨干教师（2010）；省首批企业科技特派员（2010）；

承担科研项目
1、江苏省南京市玄武区奶牛DHI测定中心基础建设项目（8ZG161）， 农业部畜禽良种工程基础建设项目，2016-2017； 2、长三角地区生态优质高效乳业创新体系研究 [CX(17)1005]-课题一，江苏省农业科技自主创新资金项目（省财政厅），2017-2020； 3、基于DHI技术建立江苏省良种奶牛数据库[ CX(18)3014]， 江苏省农业科技自主创新资金项目（省财政厅），2018-2021； 4、奶牛生产性能测定（DHI）技术的研发与示范推广[SXG[2016]312]，江苏省农业三新工程项目，2016-2017； 5、2016年度南京农业大学高层次人才引进项目（804090），2016-2021； 6、DHI标准物质中致病微生物检测（HY0039），农业部全国畜牧总站，2017-2018；7、利用DHI技术测定江苏地区1000头奶牛（131821301064071027），农业部全国畜牧总站，2018-2019； 8、牦牛良种繁育及精准饲喂技术集成与示范（2020-HZ04-B），青海省海南州科技计划项目，2019-2020，9、青海牦牛、犏牛早期发情及妊娠快速鉴定技术研究及示范（2021-HZ02-D），青海省海南州科技计划项目，2020-2021；10、Ufm1泛素化样修饰系统E3连接酶-Ufl1缺失调控动物肝脏发育和原发性肝纤维化发生的分子机制，2020年度国家自然科学基金面上项目( 31970413），2020-2023；11、国家重点研发计划（2018YFC1200201）PI项目：特殊生物资源（本地牛品种）特征溯源数学模型的建立，2018-2021； 12、Smad9基因在卵巢等级建立中的作用，2016年度国家自然科学基金面上项目( 31572265），2016-2017；13、CIBZ基因在神经干细胞移植靶向性修复小鼠脊髓损伤中的作用，2014年度国家自然科学基金面上项目(31372207)，2014-2017；

研究领域

养牛学；牛遗传育种；动物生理；"动物遗传育种与繁殖；"

近期论文

1. Cao Y, Li, R, Shen M. Zou Y, Jiang Q, Liu S, Lu C, Li H, Liu H*, Cai Y*. DDRGK1, a crucial player of ufmylation system, is indispensable for autophagic degradation by regulating lysosomal function. Cell Death Dis. 2021 Apr 20; 12:416.
2. Quintero M, Liu S, Xia Y, Huang Y, Zou Y, Li G, Hu L, Singh N, Blumberg R, Cai Y, Xu H, Li H. Cdk5rap3 is essential for intestinal Paneth cell development and maintenance. Cell Death Dis. 2021 Jan 27; 12(1):131.
3. Shen Y, Zou Y, Li J, Chen F, Li H, Cai Y*. CDK5RAP3, a Novel Nucleoplasmic Shuttle, Deeply Regulates HSF1-Mediated Heat Stress Response and Protects Mammary Epithelial Cells from Heat Injury. Int J Mol Sci. 2020 Nov 9; 21(21):8400.
4. Cao Y, Li R, Li W, Liu H, Cai Y*. Melatonin Attenuates Peroxynitrite-Induced Meiosis Dysfunction in Porcine Oocytes. Reprod Sci. 2020 May; 28(5):1281-1289.
5. Song W, Sheng L, Chen F, Tian Y, Li L, Wang G, Li H, Cai Y*. C. sakazakii activates AIM2 pathway accompanying with excessive ER stress response in mammalian mammary gland epithelium. Cell Stress Chaperones. 2020 Mar; 25(2):223-233.
6. Yang F, Zhang M, Rong Y, Liu Z, Yang S, Zhang W, Li J, Cai Y*. A Novel SNPs in Alpha-Lactalbumin Gene Effects on Lactation Traits in Chinese Holstein Dairy Cows. Animals (Basel). 2019 Dec 29; 10(1):60.
7. Han F, Xu H, Shen JX, Pan C, Yu ZH, Chen JJ, Zhu XL, Cai YF, Lu YP. RhoA/Rock2/Limk1/cofilin1 pathway is involved in attenuation of neuronal dendritic spine loss by paeonol in the frontal cortex of D-galactose and aluminum‑induced Alzheimer's disease‑like rat model. Acta Neurobiol Exp (Wars). 2020; 80(3):225-244.
8. Yang F, Chen F, Li L, Yan L, Badri T, Lv C, Yu D, Zhang M, Jang X, Li J, Yuan L, Wang G, Li H, Li J*, Cai Y*. Three novel players：PTK2B, SYK and TNFRSF21 were identified to be involved in the regulation of bovine mastitis susceptibility via GWAS and post-transcriptional analysis. Front Immunol. 2019; 10:1579.
9. Zhu H, Bhatt B, SivaprakasaS, Cai Y, Liu S, Kodeboyina S, Patel N, Savage N, Sharma A, Kaufman R, Li H, and Singh N*. Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR[J]. Nature Communications, 2019; 10(1):1084.
10. Chen F, Xing C, Zhang W, Li J, Hu T, Li L, Li H*, Cai Y*. Salubrinal, a novel inhibitor of eIF-2α dephosphorylation, promotes erythropoiesis at early stage targeted by Ufmylation pathway [J]. J Cell Physiol, 2019; 234(10):18560-18570.
11. Cai Yafei*, Zhu Guangxun#, Liu Siyang , Pan Zezheng, Quintero Michaela, Poole Candace J, Lu Chunwan, Zhu Huabin, Islam Bianca, Riggelen Jan van, Browning Darren, Liu Kebin, Blumberg Richard, Singh Nagendra & Li Honglin*. Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation. Cell Discovery, 2019; 5:7.
12. Chen J, Xing C, Yan L, Wang Y, Wang H, Zhang Z, Yu D, Li J, Li H, Li J, Cai Y*. Transcriptome profiling reveals the role of ZBTB38 knock-down in human neuroblastoma. PeerJ, 2019; 7: e6352.
13. Li J, Yue G, Ma W, Zhang A, Zou J, Cai Y, Tang X, Wang J, Liu J, Li H, Su H. Ufm1-Specific Ligase Ufl1 Regulates Endoplasmic Reticulum Homeostasis and Protects Against Heart Failure. Circ Heart Fail. 2018; 11(10):e004917.
14. Badri TM, Chen KL, Alsiddig MA, Li L1, Cai Y, Wang GL. Genetic polymorphism in Hsp90AA1 gene is associated with the thermotolerance in Chinese Holstein cows. Cell Stress Chaperones. 2018 Jul; 23(4):639-651.
15. Yu Daolun, Zhang Li, Wang Hejian, Chen Fanghui, Chen Jie, Zhang Zongmeng, Li Jie, Xing Chaofeng, Li Honglin, Li Jun, Cai Yafei*. A potential role for SMAD9 in goose follicular selection through regulation of mRNA levels of luteinizing hormone receptor. Theriogenology, 2019; 135 (2019): 204-212.
16. Zhang Li, Wang Hejian, Yu Daolun, Chen Jie, Xing Chaofeng, Li Jie, Li Jun & Cai Yafei*. The effects of mouse ovarian granulosa cell function and related gene expression by suppressing BMP/Smad signaling pathway. Animal Cells and Systems, 2018; 22(5):317-323.
17. Chen J, Yan L, Wang H, Zhang Z, Yu D, Xing C, Li J, Li H, Li J, Cai Y*. ZBTB38, a novel regulator of autophagy initiation targeted by RB1CC1/FIP200 in spinal cord injury. Gene. 2018 Jul 31; 678:8-16.
18. Zhang Z, Chen J, Chen F, Yu D, Li R, Lv C, Wang H, Li H, Li J, Cai Y* Tauroursodeoxycholic acid alleviates secondary injury in the spinal cord via up-regulation of CIBZ gene. Cell Stress Chaperones. 2018; 23(4):551-560.
19. Zhu XL, Chen JJ, Han F, Pan C, Zhuang TT, Cai YF, Lu YP. Novel antidepressant effects of Paeonol alleviate neuronal injury with concomitant alterations in BDNF, Rac1 and RhoA levels in chronic unpredictable mild stress rats. Psychopharmacology (Berl). 2018; 235(7)2177-2191.
20. Cai Y*, Li J, Zhang Z, Chen J, Zhu Y, Li R, Chen J, Gao L, Liu R, Teng Y.Zbtb38 is a novel target for spinal cord injury. Oncotarget. 2017, Jul 11; 8(28):45356-45366.
21. Li J, Wang Q,Chen F, Wang H, Chen J,Huo J and Cai Y*. SNPs of CD14 change the mastitis morbidity of Chinese Holstein. Molecular Medicine Reports. 2017; 16(6):9102-9110.
22. Teng Y, Cai Y, Pi W, Gao L, Shay C. Augmentation of the anticancer activity of CYT997 in human prostate cancer by inhibiting Src activity. J Hematol Oncol. 2017 Jun 12; 10(1):118.
23. Miller C, Cai Y, Patton T, Graves SH, Li H, Sabbatini ME. RCAD/BiP pathway is necessary for the proper synthesis of digestive enzymes and secretory function of the exocrine pancreas. Am J Physiol Gastrointest Liver Physiol. 2017 Mar 1; 312(3):G314-G326.
24. Han F, Zhuang TT, Chen JJ, Zhu XL, Cai YF, Lu YP. Novel derivative of Paeonol, Paeononlsilatie sodium, alleviates behavioral damage and hippocampal dendritic injury in Alzheimer's disease concurrent with cofilin1/phosphorylated-cofilin1 and RAC1/CDC42 alterations in rats. PLoS One. 2017; 12(9):e0185102.
25. Cai Y, Singh N, Li H. Essential role of Ufm1 conjugation in the hematopoietic system. Exp Hematol. 2016 Mar 24. 44(6):442-446.
26. Lu Chunwan, Makala Levi, Wu Daqing, Cai Yafei*. Targeting Translation: eIF4E as an Emerging Anti-Cancer Drug Target. Expert Reviews in Molecular Medicine, 2016; 18(e2):1-13.
27. Xie X, Tang SC, Cai Y, Pi W, Deng L, Wu G, Chavanieu A, Teng Y. Suppression of breast cancer metastasis through the inactivation of ADP-ribosylation factor. Oncotarget, 2016 Sep 6;7(36):58111-58120.
28. da Silva SR, Paiva SL, Bancerz M, Geletu M, Lewis AM, Chen J, Cai Y, Lukkarila JL, Li H, Gunning PT. A selective inhibitor of the UFM1-activating enzyme, UBA5. Bioorg Med Chem Lett, 2016; 26(18):4542-7.
29. Cai Y, Pi W, Sivaprakasam S, Zhu X, Zhang M, Chen J, et al. UFBP1, a Key Component of the Ufm1 Conjugation System, Is Essential for Ufmylation-Mediated Regulation of Erythroid Development. PLoS Genet, 2015; 11(11): e1005643.
30. Huang Pin, Lu Chunwan #, Li Jun ,Xu Jun, Liu Zaiqun, Wang Qiang, Wang Zhao, HuoJiayan, Li Honglin, Teng Yong, Cai Yafei*. Mutations in HSP70-2 gene change the susceptibility to clinical mastitis in Chinese Holstein. Gene, 2015; 559(1):62-72.
31. Xu Jun, Li Jun #, Wang Haosen #, Wang Guanglin #, Chen Jie, Huang Pin, Cheng Jienan, Gan Lu, Wang Zhao & Cai Yafei*. A novel SMAD family protein, SMAD9 is involved in follicular initiation and changes egg yield of geese via synonymous mutations in exon1 and intron2. Mol Biol Rep, 2015; 42:289-302.
32. Zhang M, Zhu X, Zhang Y, Cai Y, Chen J, Sivaprakasam S, Gurav A, Pi W, Makala L, Wu J, Pace B, Tuan-Lo D, Ganapathy V, Singh N, Li H. RCAD/Ufl1, a Ufm1 E3 ligase, is essential for hematopoietic stem cell function and murine hematopoiesis. Cell Death Differ, 2015 May 8; 22(12):1922-34.
33. Cai Yafei, Li Jun, Yang Shiyong, Li Ping, Zhang Xuan, Liu Honglin*. CIBZ, a novel BTB domain-containing protein, is involved in mouse spinal cord injury via mitochondrial pathway independent of p53 gene. PLoS ONE, 2012; 7(3): e33156.
34. Cheng Jienan, Li Jun, Zhang Wenxin, Cai Yafei*, Wang Genlin. Mutations in lipopolysaccharide-binding protein (LBP) gene change the susceptibility to clinical mastitis in Chinese Holstein. Molecular Biology Reports, 2012; 39(10): 9601-9612.
35. Yang Fan, Li Lian, Liu Huiling, Cai Yafei*, Wang Genlin. Polymorphism in the exon 4 of β-lactoglobulin variant B precursor gene and its association with milk traits and protein structure in Chinese Holstein. Molecular Biology Reports,2012; 29(4): 3957-3964.
36. Chen Jie, Liu Huiling,Cai Yafei*, Wang Genlin, Liu Honglin, Li Jing.Mutations in the exon 10 of Prolactin receptor gene (PRLR) change the egg production performance in Wanjiang White Goose. Molecular Biology Reports, 2012; 39(1): 475-483.
37. Cai Ya-Fei*, Fan Rui, Hua Tian-Miao, Liu Hui-Ling, Li Jing. Nimodipine alleviates apoptosis-mediated impairments through mitochondrial pathway after spinal cord injury. Current Zoology, 2011; 57(3):340-349.
38. Chen Jie, Wang Genlin, Cai Yafei*. High Mutation Rate in PRL Intron 2 Regulates the Egg-laying Performance in the Two-line Hybrid Wanjiang White Goose, Journal of Applied Animal Research, 2011; 39(3):175-180.
39. Liu Huiling, Li Jing, Yang Fan, Cai Yafei*. Molecular Sexing of Endangered Cranes Based on CHD-W gene. Journal of Applied Animal Research, 2011; 39(3): 212-217.
40. Liu Qinghua, Wang Yan, Cai Yafei*, Liu Huiling, Chen Jie, Li Ping, Cheng Jienan, Liu Honglin. T Lymphocyte Selection is Indispensible for the Development of Goose Bursa of Fabricius. Current Research in Poultry Science, 2011; 1(2):37-53.
41. Xu Shiyong, Sun Yan, Ding Hongmei, Wang Meng, Cai Yafei*, Chen Jie, Liu Honglin. Efficient production of transgenic chickens using self-inactive HIV-based lentiviral vectors. Current Zoology, 2009; 55(5):383-387.
42. Cai Yafei, Liu Qinghua, Xing Guangdong, Wang Genlin. Polymorphism of the promoter region of hsp70 gene and its relationship with the expression of HSP70mRNA, HSF1mRNA, Bcl-2mRNA and Bax-αmRNA in lymphocytes in peripheral blood of heat shock dairy cows. Asian-Australasian Journal of Animal Science, 2005; 18(5): 734-740.
中国养牛学会会员、美国细胞生物学会会员